Skip to main content
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1990 Feb;47(2):91–98. doi: 10.1136/oem.47.2.91

Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers.

P Dumortier 1, P De Vuyst 1, P Strauss 1, J C Yernault 1
PMCID: PMC1035107  PMID: 2155652

Abstract

Asbestos body (AB) concentrations in bronchoalveolar lavage samples of 15 brake lining (BL) workers exposed only to chrysotile have been determined and compared with those from 44 asbestos cement (AC) workers extensively exposed to amphiboles. The mean AB concentrations (263 +/- 802 and 842 +/- 2086 AB/ml respectively) for those groups did not differ significantly but were much higher than those found in control groups. Analytical electron microscopy of asbestos body cores showed that in the BL group 95.6% were chrysotile fibres whereas in the AC group amphiboles accounted for 93.1%. The size characteristics of the central fibres differed for chrysotile and amphibole AB, the former being shorter and thinner. Examination of repeated bronchoalveolar lavage samples showed that the mechanisms of clearance of chrysotile fibres do not affect AB concentration for at least 10 months after cessation of exposure. It thus appears that routine counting of ABs in BAL allows the assessment of current or recent occupational exposures to asbestos. Exposures to chrysotile lead to AB concentrations comparable with those encountered in exposures to amphiboles.

Full text

PDF
94

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becklake M. R. Asbestosis criteria. Arch Pathol Lab Med. 1984 Feb;108(2):93–93. [PubMed] [Google Scholar]
  2. Bégin R., Massé S., Sébastien P., Bossé J., Rola-Pleszczynski M., Boctor M., Côté Y., Fabi D., Dalle D. Asbestos exposure and retention as determinants of airway disease and asbestos alveolitis. Am Rev Respir Dis. 1986 Dec;134(6):1176–1181. doi: 10.1164/arrd.1986.134.5.1176. [DOI] [PubMed] [Google Scholar]
  3. Churg A. M., Warnock M. L. Analysis of the cores of ferruginous (asbestos) bodies from the general population. III. Patients with environmental exposure. Lab Invest. 1979 May;40(5):622–626. [PubMed] [Google Scholar]
  4. Churg A. M., Warnock M. L. Asbestos and other ferruginous bodies: their formation and clinical significance. Am J Pathol. 1981 Mar;102(3):447–456. [PMC free article] [PubMed] [Google Scholar]
  5. Churg A., Warnock M. L. Analysis of the cores of ferruginous (asbestos) bodies from the general population. I. Patients with and without lung cancer. Lab Invest. 1977 Sep;37(3):280–286. [PubMed] [Google Scholar]
  6. Churg A., Wiggs B. Fiber size and number in workers exposed to processed chrysotile asbestos, chrysotile miners, and the general population. Am J Ind Med. 1986;9(2):143–152. doi: 10.1002/ajim.4700090205. [DOI] [PubMed] [Google Scholar]
  7. DAVIS J. M. THE ULTRASTRUCTURE OF ASBESTOS BODIES FROM HUMAN LUNG. Br J Exp Pathol. 1964 Dec;45:642–646. [PMC free article] [PubMed] [Google Scholar]
  8. De Vuyst P., Dumortier P., Moulin E., Yourassowsky N., Roomans P., de Francquen P., Yernault J. C. Asbestos bodies in bronchoalveolar lavage reflect lung asbestos body concentration. Eur Respir J. 1988 Apr;1(4):362–367. [PubMed] [Google Scholar]
  9. De Vuyst P., Dumortier P., Moulin E., Yourassowsky N., Yernault J. C. Diagnostic value of asbestos bodies in bronchoalveolar lavage fluid. Am Rev Respir Dis. 1987 Nov;136(5):1219–1224. doi: 10.1164/ajrccm/136.5.1219. [DOI] [PubMed] [Google Scholar]
  10. De Vuyst P., Mairesse M., Gaudichet A., Dumortier P., Jedwab J., Yernault J. C. Mineralogical analysis of bronchoalveolar lavage fluid as an aid to diagnosis of "imported" pleural asbestosis. Thorax. 1983 Aug;38(8):628–629. doi: 10.1136/thx.38.8.628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Di Menza L., Hirsch A., Sebastien P., Gaudichet A., Bignon J. Assessment of past asbestos exposure in patients: occupational questionnaire versus monitoring in broncho-alveolar lavage. IARC Sci Publ. 1980;(30):609–614. [PubMed] [Google Scholar]
  12. Dumortier P., De Vuyst P. Object-marking, a bridge between light and analytical electron microscopy for particles characterization. J Electron Microsc Tech. 1988 Feb;8(2):229–230. doi: 10.1002/jemt.1060080213. [DOI] [PubMed] [Google Scholar]
  13. Gellert A. R., Kitajewska J. Y., Uthayakumar S., Kirkham J. B., Rudd R. M. Asbestos fibres in bronchoalveolar lavage fluid from asbestos workers: examination by electron microscopy. Br J Ind Med. 1986 Mar;43(3):170–176. doi: 10.1136/oem.43.3.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gylseth B., Mowé G., Wannag A. Fibre type and concentration in the lungs of workers in an asbestos cement factory. Br J Ind Med. 1983 Nov;40(4):375–379. doi: 10.1136/oem.40.4.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Holden J., Churg A. Asbestos bodies and the diagnosis of asbestosis in chrysotile workers. Environ Res. 1986 Feb;39(1):232–236. doi: 10.1016/s0013-9351(86)80024-x. [DOI] [PubMed] [Google Scholar]
  16. Morgan A., Holmes A. Concentrations and dimensions of coated and uncoated asbestos fibres in the human lung. Br J Ind Med. 1980 Feb;37(1):25–32. doi: 10.1136/oem.37.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Morgan A., Holmes A. The enigmatic asbestos body: its formation and significance in asbestos-related disease. Environ Res. 1985 Dec;38(2):283–292. doi: 10.1016/0013-9351(85)90092-1. [DOI] [PubMed] [Google Scholar]
  18. Pooley F. D. Asbestos bodies, their formation, composition and character. Environ Res. 1972 Dec;5(4):363–379. doi: 10.1016/0013-9351(72)90039-4. [DOI] [PubMed] [Google Scholar]
  19. Roggli V. L., McGavran M. H., Subach J., Sybers H. D., Greenberg S. D. Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma: a study of 25 cases. Cancer. 1982 Dec 1;50(11):2423–2432. doi: 10.1002/1097-0142(19821201)50:11<2423::aid-cncr2820501130>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  20. Roggli V. L., Pratt P. C., Brody A. R. Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases. Br J Ind Med. 1986 Jan;43(1):18–28. doi: 10.1136/oem.43.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sebastien P., Armstrong B., Monchaux G., Bignon J. Asbestos bodies in bronchoalveolar lavage fluid and in lung parenchyma. Am Rev Respir Dis. 1988 Jan;137(1):75–78. doi: 10.1164/ajrccm/137.1.75. [DOI] [PubMed] [Google Scholar]
  22. Sébastien P. Possibilités actuelles de la biométrologie des poussières sur échantillons de liquide de lavage bronchoalvéolaire. Ann Biol Clin (Paris) 1982;40(3):279–293. [PubMed] [Google Scholar]
  23. Wagner J. C., Berry G., Skidmore J. W., Timbrell V. The effects of the inhalation of asbestos in rats. Br J Cancer. 1974 Mar;29(3):252–269. doi: 10.1038/bjc.1974.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wagner J. C., Pooley F. D. Mineral fibres and mesothelioma. Thorax. 1986 Mar;41(3):161–166. doi: 10.1136/thx.41.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES