Abstract
The discrepancy in previous reports of the action of aluminium on the lung may be explained by differences between stamped and granular aluminium powders. A stamped powder of the variety causing pulmonary fibrosis showed a brisk reaction with water, but a granular powder was unreactive. This difference is primarily due to the granular particles being covered by inert aluminium oxide, the formation of which is partially prevented in the stamping process by stearine and mineral oil. The reactivity of the flake-like stamped particles is also dependent on their large surface area per unit volume.
The appearance of aluminium pneumoconiosis in Britain is explained by the introduction of mineral oil into the stamping industry for, in contrast to stearine, mineral oil permits the powder to react with water. The lung damage is believed to be caused by a soluble form of aluminium.
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Selected References
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- Crombie D. W., Blaisdell J. L., Macpherson G. The Treatment of Silicosis by Aluminum Powder. Can Med Assoc J. 1944 Apr;50(4):318–328. [PMC free article] [PubMed] [Google Scholar]
- Denny J. J., Robson W. D., Irwin D. A. THE PREVENTION OF SILICOSIS BY METALLIC ALUMINUM II. Can Med Assoc J. 1939 Mar;40(3):213–228. [PMC free article] [PubMed] [Google Scholar]
- MCLAUGHLIN A. I., KAZANTZIS G., KING E., TEARED, PORTER R. J., OWEN R. Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminium dust. Br J Ind Med. 1962 Oct;19:253–263. doi: 10.1136/oem.19.4.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NAGELSCHMIDT G. The relation between lung dust and lung pathology in pneumoconiosis. Br J Ind Med. 1960 Oct;17:247–259. doi: 10.1136/oem.17.4.247. [DOI] [PMC free article] [PubMed] [Google Scholar]