Abstract
Three stamped aluminium powders were injected into the lungs of rats. One powder contained stearine and another mineral oil, whilst the third had had its lubricant removed. The powders produced a rapid and marked fibrosis of equal severity. It is concluded that aluminium rather than any additive in the powders is the fibrogenic agent.
The protective action of stearine demonstrated in vitro was not confirmed in vivo, suggesting that pulmonary fibrosis may also occur in men handling stearine-containing powders. Such a case has recently been reported by McLaughlin et al. (1962), but this is exceptional to the general industrial experience.
A granular aluminium powder was also injected into the lungs of rats. In accordance with the results of in vitro experiments, this produced only minimal fibrosis, contrasting strongly with the action of the stamped powders.
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- CORRIN B. ALUMINIUM PNEUMOCONIOSIS. I. IN VITRO COMPARISON OF STAMPED ALUMINIUM POWDERS CONTAINING DIFFERENT LUBRICATING AGENTS AND A GRANULAR ALUMINIUM POWDER. Br J Ind Med. 1963 Oct;20:264–267. doi: 10.1136/oem.20.4.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HEPPLESTON A. G. The pathological anatomy of simple pneumokoniosis in coal workers. J Pathol Bacteriol. 1953 Jul;66(1):235–246. doi: 10.1002/path.1700660127. [DOI] [PubMed] [Google Scholar]
- KING E. J., HARRISON C. V., MOHANTY G. P., YOGANATHAN M. The effect of aluminium and of aluminium containing 5 per cent. of quartz in the lungs of rats. J Pathol Bacteriol. 1958 Apr;75(2):429–434. doi: 10.1002/path.1700750222. [DOI] [PubMed] [Google Scholar]
- MCLAUGHLIN A. I., KAZANTZIS G., KING E., TEARED, PORTER R. J., OWEN R. Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminium dust. Br J Ind Med. 1962 Oct;19:253–263. doi: 10.1136/oem.19.4.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITCHELL J., MANNING G. B., MOLYNEUX M., LANE R. E. Pulmonary fibrosis in workers exposed to finely powdered aluminium. Br J Ind Med. 1961 Jan;18:10–23. doi: 10.1136/oem.18.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]