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. 1992 Aug;49(8):545–555. doi: 10.1136/oem.49.8.545

Effects of occupational exposure to mercury vapour on the central nervous system.

S Langworth 1, O Almkvist 1, E Söderman 1, B O Wikström 1
PMCID: PMC1039287  PMID: 1515346

Abstract

Possible effects of mercury on the central nervous system (CNS) were examined in a group of chloralkali workers exposed to mercury (n = 89) and compared with a control group (n = 75), by registration of subjective symptoms, personality changes, forearm tremor, and performance on six computerised psychometric tests in the two groups. The groups were similar in age, education, verbal comprehension, and work tasks. In the chloralkali group, median blood mercury concentration (B-Hg) was 55 nmol/l, serum mercury concentration (S-Hg) 45 nmol/l, and urine mercury concentration (U-Hg) 14.3 nmol/mmol creatinine (25.4 micrograms/g creatinine). Corresponding concentrations in the control group were 15 nmol/l, 4 nmol/l, and 1.1 nmol/mmol creatinine (1.9 micrograms/g creatinine) respectively. The number of self reported symptoms, the scores for tiredness and confusion in the profile of mood states (POMS), and the degree of neuroticism in the Eysenck personality inventory (EPI), were significantly higher in the mercury exposed group compared with the controls. Performance on the psychometric tests and tremor frequency spectra did not differ significantly between the two groups. Dose-response calculations showed weak but statistically significant relations between symptom prevalence and current mercury concentrations in both blood and urine. The performance on three of the psychometric tests was negatively correlated with earlier peak exposures. The findings indicate a slight mercury induced effect on the CNS among the chloralkali workers.

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Selected References

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  1. Baker E. L., Letz R. E., Fidler A. T., Shalat S., Plantamura D., Lyndon M. A computer-based neurobehavioral evaluation system for occupational and environmental epidemiology: methodology and validation studies. Neurobehav Toxicol Teratol. 1985 Jul-Aug;7(4):369–377. [PubMed] [Google Scholar]
  2. Baker E. L., Letz R., Fidler A. A computer-administered neurobehavioral evaluation system for occupational and environmental epidemiology. Rationale, methodology, and pilot study results. J Occup Med. 1985 Mar;27(3):206–212. [PubMed] [Google Scholar]
  3. Bunn W. B., 3rd, McGill C. M., Barber T. E., Cromer J. W., Jr, Goldwater L. J. Mercury exposure in chloralkali plants. Am Ind Hyg Assoc J. 1986 May;47(5):249–254. doi: 10.1080/15298668691389720. [DOI] [PubMed] [Google Scholar]
  4. Chapman L. J., Sauter S. L., Henning R. A., Dodson V. N., Reddan W. G., Matthews C. G. Differences in frequency of finger tremor in otherwise asymptomatic mercury workers. Br J Ind Med. 1990 Dec;47(12):838–843. doi: 10.1136/oem.47.12.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fawer R. F., de Ribaupierre Y., Guillemin M. P., Berode M., Lob M. Measurement of hand tremor induced by industrial exposure to metallic mercury. Br J Ind Med. 1983 May;40(2):204–208. doi: 10.1136/oem.40.2.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fidler A. T., Baker E. L., Letz R. E. Neurobehavioural effects of occupational exposure to organic solvents among construction painters. Br J Ind Med. 1987 May;44(5):292–308. doi: 10.1136/oem.44.5.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hogstedt C., Hane M., Agrell A., Bodin L. Neuropsychological test results and symptoms among workers with well-defined long-term exposure to lead. Br J Ind Med. 1983 Feb;40(1):99–105. doi: 10.1136/oem.40.1.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Langolf G. D., Chaffin D. B., Henderson R., Whittle H. P. Evaluation of workers exposed to elemental mercury using quantitative tests of tremor and neuromuscular functions. Am Ind Hyg Assoc J. 1978 Dec;39(12):976–984. doi: 10.1080/0002889778507898. [DOI] [PubMed] [Google Scholar]
  9. Langworth S., Elinder C. G., Göthe C. J., Vesterberg O. Biological monitoring of environmental and occupational exposure to mercury. Int Arch Occup Environ Health. 1991;63(3):161–167. doi: 10.1007/BF00381563. [DOI] [PubMed] [Google Scholar]
  10. Langworth S., Elinder C. G., Sundquist K. G., Vesterberg O. Renal and immunological effects of occupational exposure to inorganic mercury. Br J Ind Med. 1992 Jun;49(6):394–401. doi: 10.1136/oem.49.6.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Langworth S., Kölbeck K. G., Akesson A. Mercury exposure from dental fillings. II. Release and absorption. Swed Dent J. 1988;12(1-2):71–72. [PubMed] [Google Scholar]
  12. Mackert J. R., Jr Factors affecting estimation of dental amalgam mercury exposure from measurements of mercury vapor levels in intra-oral and expired air. J Dent Res. 1987 Dec;66(12):1775–1780. doi: 10.1177/00220345870660121501. [DOI] [PubMed] [Google Scholar]
  13. Miller J. M., Chaffin D. B., Smith R. G. Subclinical psychomotor and neuromuscular changes in workers exposed to inorganic mercury. Am Ind Hyg Assoc J. 1975 Oct;36(10):725–733. doi: 10.1080/0002889758507331. [DOI] [PubMed] [Google Scholar]
  14. Piikivi L., Hänninen H., Martelin T., Mantere P. Psychological performance and long-term exposure to mercury vapors. Scand J Work Environ Health. 1984 Feb;10(1):35–41. doi: 10.5271/sjweh.2365. [DOI] [PubMed] [Google Scholar]
  15. Piikivi L., Hänninen H. Subjective symptoms and psychological performance of chlorine-alkali workers. Scand J Work Environ Health. 1989 Feb;15(1):69–74. doi: 10.5271/sjweh.1880. [DOI] [PubMed] [Google Scholar]
  16. Roels H., Abdeladim S., Braun M., Malchaire J., Lauwerys R. Detection of hand tremor in workers exposed to mercury vapor: a comparative study of three methods. Environ Res. 1989 Aug;49(2):152–165. doi: 10.1016/s0013-9351(89)80060-x. [DOI] [PubMed] [Google Scholar]
  17. Roels H., Gennart J. P., Lauwerys R., Buchet J. P., Malchaire J., Bernard A. Surveillance of workers exposed to mercury vapour:validation of a previously proposed biological threshold limit value for mercury concentration in urine. Am J Ind Med. 1985;7(1):45–71. doi: 10.1002/ajim.4700070106. [DOI] [PubMed] [Google Scholar]
  18. Roels H., Lauwerys R., Buchet J. P., Bernard A., Barthels A., Oversteyns M., Gaussin J. Comparison of renal function and psychomotor performance in workers exposed to elemental mercury. Int Arch Occup Environ Health. 1982;50(1):77–93. doi: 10.1007/BF00432495. [DOI] [PubMed] [Google Scholar]
  19. Rosenman K. D., Valciukas J. A., Glickman L., Meyers B. R., Cinotti A. Sensitive indicators of inorganic mercury toxicity. Arch Environ Health. 1986 Jul-Aug;41(4):208–215. doi: 10.1080/00039896.1986.9938335. [DOI] [PubMed] [Google Scholar]
  20. Schuckmann F. Study of preclinical changes in workers exposed to inorganic mercury in chloralkali plants. Int Arch Occup Environ Health. 1979;44(3):193–200. doi: 10.1007/BF00381134. [DOI] [PubMed] [Google Scholar]
  21. Smith P. J., Langolf G. D., Goldberg J. Effect of occupational exposure to elemental mercury on short term memory. Br J Ind Med. 1983 Nov;40(4):413–419. doi: 10.1136/oem.40.4.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Smith R. G., Vorwald A. J., Patil L. S., Mooney T. F., Jr Effects of exposure to mercury in the manufacture of chlorine. Am Ind Hyg Assoc J. 1970 Nov-Dec;31(6):687–700. doi: 10.1080/0002889708506315. [DOI] [PubMed] [Google Scholar]
  23. Soter N. A., Wasserman S. I., Austen K. F. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. doi: 10.1056/NEJM197603252941302. [DOI] [PubMed] [Google Scholar]
  24. Sternberg S. Memory-scanning: mental processes revealed by reaction-time experiments. Am Sci. 1969 Winter;57(4):421–457. [PubMed] [Google Scholar]
  25. Sällsten G., Barregård L., Järvholm B. Mercury in the Swedish chloralkali industry--an evaluation of the exposure and preventive measures over 40 years. Ann Occup Hyg. 1990 Apr;34(2):205–214. doi: 10.1093/annhyg/34.2.205. [DOI] [PubMed] [Google Scholar]
  26. Triebig G., Schaller K. H. Neurotoxic effects in mercury-exposed workers. Neurobehav Toxicol Teratol. 1982 Nov-Dec;4(6):717–720. [PubMed] [Google Scholar]
  27. Verberk M. M., Sallé H. J., Kemper C. H. Tremor in workers with low exposure to metallic mercury. Am Ind Hyg Assoc J. 1986 Sep;47(9):559–562. doi: 10.1080/15298668691390232. [DOI] [PubMed] [Google Scholar]

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