Abstract
A study of a syndrome characterised by deficient or inadequate Meibomian gland secretions, minimal or transient symptoms suggestive of ocular dryness, fluorescein staining of the cornea (often detected only after delayed observation or sequential instillation of stain), and contact lens intolerance is described. Clinical and cytological studies indicate that the syndrome is due to obstruction of the Meibomian gland orifices by desquamated epithelial cells that tend to aggregate in keratotic clusters, which results in alteration of the Meibomian glands' contribution to the precorneal tear film. Further complication may result from bacterial proliferation in the desquamated keratotic cells and the release of the bacteria and their toxic products into the precorneal tear film from these reservoirs in the excretory pathways of the Meibomian glands.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allen A. C., Sirota J. H. The Morphogenesis and Significance of Degenerative Verrucal Endocardiosis (Terminal Endocarditis, Endocarditis Simplex, Nonbacterial Thrombotic Endocarditis). Am J Pathol. 1944 Nov;20(6):1025–1055. [PMC free article] [PubMed] [Google Scholar]
- Keith C. G. Seborrhoeic blepharo-kerato-conjunctivitis. Trans Ophthalmol Soc U K. 1967;87:85–103. [PubMed] [Google Scholar]
- Korb D. R., Henriquez A. S. Meibomian gland dysfunction and contact lens intolerance. J Am Optom Assoc. 1980 Mar;51(3):243–251. [PubMed] [Google Scholar]
- Korb D. R., Herman J. P. Corneal staining subsequent to sequential fluorescein instillations. J Am Optom Assoc. 1979 Mar;50(3):361–367. [PubMed] [Google Scholar]
- McCulley J. P., Sciallis G. F. Meibomian keratoconjunctivitis. Am J Ophthalmol. 1977 Dec;84(6):788–793. doi: 10.1016/0002-9394(77)90497-4. [DOI] [PubMed] [Google Scholar]
- NORN M. S. FOAM AT OUTER PALPEBRAL CANTHUS. Acta Ophthalmol (Copenh) 1963;41:531–537. doi: 10.1111/j.1755-3768.1963.tb03566.x. [DOI] [PubMed] [Google Scholar]