Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1983 Mar;67(3):137–142. doi: 10.1136/bjo.67.3.137

Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion.

G E Trope, G D Lowe, B M McArdle, J T Douglas, C D Forbes, C M Prentice, W S Foulds
PMCID: PMC1039995  PMID: 6824618

Abstract

Blood viscosity and several haemostatic factors were measured in 42 patients with long-standing retinal vein occlusion and 33 control subjects. Blood viscosity, haematocrit, plasma viscosity, fibrinogen, fibrinopeptide A, and beta-thromboglobulin were increased in the 20 subjects with capillary nonperfusion or new vessels, but not in the 22 subjects without these complications. Patients with nonperfusion or new vessels also had a lower platelet count than patients without complications. Increased levels of factor VIII antigen and decreased levels of antithrombin III were found in the retinal vein occlusion group as a whole. These findings suggest that blood viscosity, platelets, and coagulation may be involved in retinal vein occlusion and its vascular complications.

Full text

PDF
141

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bensoussan D., Levy Toledano S., Passa P., Caen J., Caniver J. Platelet hyperaggregation and increased plasma level of Von Willebrand factor in diabetics with retinopathy. Diabetologia. 1975 Aug;11(4):307–312. doi: 10.1007/BF00422396. [DOI] [PubMed] [Google Scholar]
  2. Bowell R. E., Marmion V. J., McCarthy C. F. Treatment of central retinal vein thrombosis with ancrod. Lancet. 1970 Jan 24;1(7639):173–174. doi: 10.1016/s0140-6736(70)90409-5. [DOI] [PubMed] [Google Scholar]
  3. Douglas J. T., Shah M., Lowe G. D., Belch J. J., Forbes C. D., Prentice C. R. Plasma fibrinopeptide A and beta-thromboglobulin in pre-eclampsia and pregnancy hypertension. Thromb Haemost. 1982 Feb 26;47(1):54–55. [PubMed] [Google Scholar]
  4. Fuller J. H., Keen H., Jarrett R. J., Omer T., Meade T. W., Chakrabarti R., North W. R., Stirling Y. Haemostatic variables associated with diabetes and its complications. Br Med J. 1979 Oct 20;2(6196):964–966. doi: 10.1136/bmj.2.6196.964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hayreh S. S., van Heuven W. A., Hayreh M. S. Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. Arch Ophthalmol. 1978 Feb;96(2):311–323. doi: 10.1001/archopht.1978.03910050179015. [DOI] [PubMed] [Google Scholar]
  6. Kohner E. M., Pettit J. E., Hamilton A. M., Bulpitt C. J., Dollery C. T. Streptokinase in central retinal vein occlusion: a controlled clinical trial. Br Med J. 1976 Mar 6;1(6009):550–553. doi: 10.1136/bmj.1.6009.550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Letcher R. L., Chien S., Pickering T. G., Sealey J. E., Laragh J. H. Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen and concentration. Am J Med. 1981 Jun;70(6):1195–1202. doi: 10.1016/0002-9343(81)90827-5. [DOI] [PubMed] [Google Scholar]
  8. Lowe G. D., Campbell A. F., Meek D. R., Forbes C. D., Prentice C. R. Subcutaneous ancrod in prevention of deep-vein thrombosis after operation for fractured neck of femur. Lancet. 1978 Sep 30;2(8092 Pt 1):698–700. doi: 10.1016/s0140-6736(78)92701-0. [DOI] [PubMed] [Google Scholar]
  9. Lowe G. D., Forbes C. D. Blood rheology and thrombosis. Clin Haematol. 1981 Jun;10(2):343–367. [PubMed] [Google Scholar]
  10. Lowe G. D. Laboratory evaluation of hypercoagulability. Clin Haematol. 1981 Jun;10(2):407–442. [PubMed] [Google Scholar]
  11. Lowe G. D., Lowe J. M., Drummond M. M., Reith S., Belch J. J., Kesson C. M., Wylie A., Foulds W. S., Forbes C. D., MacCuish A. C. Blood viscosity in young male diabetics with and without retinopathy. Diabetologia. 1980 May;18(5):359–363. doi: 10.1007/BF00276814. [DOI] [PubMed] [Google Scholar]
  12. Lowe G. D., McArdle B. M., Stromberg P., Lorimer A. R., Forbes C. D., Prentice C. R. Increased blood viscosity and fibrinolytic inhibitor in type II hyperlipoproteinaemia. Lancet. 1982 Feb 27;1(8270):472–475. doi: 10.1016/s0140-6736(82)91450-7. [DOI] [PubMed] [Google Scholar]
  13. McGrath M. A., Wechsler F., Hunyor A. B., Penny R. Systemic factors contributory to retinal vein occlusion. Arch Intern Med. 1978 Feb;138(2):216–220. [PubMed] [Google Scholar]
  14. Nossel H. L., Yudelman I., Canfield R. E., Butler V. P., Jr, Spanondis K., Wilner G. D., Qureshi G. D. Measurement of fibrinopeptide A in human blood. J Clin Invest. 1974 Jul;54(1):43–53. doi: 10.1172/JCI107749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Peduzzi M., De Rosa V., Fonda S., Coccheri S. Haemostatic studies on retinal vein occlusion. Fibrinolytic response to venostasis as a prognostic factor for spontaneous recanalization. Thromb Res. 1981 Oct 1;24(1-2):105–118. doi: 10.1016/0049-3848(81)90036-0. [DOI] [PubMed] [Google Scholar]
  16. Priluck I. A. Impending central retinal vein occlusion associated with increased platelet aggregability. Ann Ophthalmol. 1979 Jan;11(1):79–84. [PubMed] [Google Scholar]
  17. Ring C. P., Pearson T. C., Sanders M. D., Wetherley-Mein G. Viscosity and retinal vein thrombosis. Br J Ophthalmol. 1976 Jun;60(6):397–410. doi: 10.1136/bjo.60.6.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Schernthaner G., Sinzinger H., Silberbauer K., Freyler H., Mühlhauser I., Kaliman J. Vascular prostacyclin, platelet sensitivity to prostaglandins and platelet-specific proteins in diabetes mellitus. Analysis of type of diabetes, state of metabolic control and diabetic microangiopathy. Horm Metab Res Suppl. 1981;11:33–43. [PubMed] [Google Scholar]
  19. Thaler E., Lechner K. Antithrombin III deficiency and thromboembolism. Clin Haematol. 1981 Jun;10(2):369–390. [PubMed] [Google Scholar]
  20. Tschopp T. B., Weiss H. J., Baumgartner H. R. Decreased adhesion of platelets to subendothelium in von Willebrand's disease. J Lab Clin Med. 1974 Feb;83(2):296–300. [PubMed] [Google Scholar]
  21. Walsh P. N., Goldberg R. E., Tax R. L., Magargal L. E. Platelet coagulant activities and retinal vein thrombosis. Thromb Haemost. 1977 Aug 31;38(2):399–406. [PubMed] [Google Scholar]
  22. Wiederholt M. Hemodilution in retinal hypoperfusion. Bibl Haematol. 1981;(47):185–191. doi: 10.1159/000402224. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES