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. 1984 Aug;68(8):581–584. doi: 10.1136/bjo.68.8.581

Effect of fluorometholone (FML) on the intraocular pressure of corticosteroid responders.

E Morrison, D B Archer
PMCID: PMC1040416  PMID: 6743628

Abstract

Steroid responsiveness to dexamethasone was determined in a large family with an established dominant form of chronic simple glaucoma. The high and intermediate steroid responders were then tested with fluorometholone--a steroid which is claimed to have a reduced risk of increasing intraocular pressure. It was found that fluorometholone had a much less pronounced ocular hypertensive effect than dexamethasone. However, one patient showed a comparable response on both drugs, and this suggests that some caution must still be exercised when using the drug on susceptible individuals. Fluorometholone was also found to be more irritable to the eye than dexamethasone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMALY M. F. ON THE DISTRIBUTION OF APPLANATION PRESSURE. I. STATISTICAL FEATURES AND THE EFFECT OF AGE, SEX, AND FAMILY HISTORY OF GLAUCOMA. Arch Ophthalmol. 1965 Jan;73:11–18. doi: 10.1001/archopht.1965.00970030013005. [DOI] [PubMed] [Google Scholar]
  2. Armaly M. F. Inheritance of dexamethasone hypertension and glaucoma. Arch Ophthalmol. 1967 Jun;77(6):747–751. doi: 10.1001/archopht.1967.00980020749006. [DOI] [PubMed] [Google Scholar]
  3. BECKER B., HAHN K. A. TOPICAL CORTICOSTEROIDS AND HEREDITY IN PRIMARY OPEN-ANGLE GLAUCOMA. Am J Ophthalmol. 1964 Apr;57:543–551. doi: 10.1016/0002-9394(64)92500-0. [DOI] [PubMed] [Google Scholar]
  4. BECKER B. INTRAOCULAR PRESSURE RESPONSE TO TOPICAL CORTICOSTEROIDS. Invest Ophthalmol. 1965 Apr;4:198–205. [PubMed] [Google Scholar]
  5. BECKER B., KOLKER A. E., ROTH F. D. Glaucoma family study. Am J Ophthalmol. 1960 Oct;50:557–567. doi: 10.1016/0002-9394(60)90233-6. [DOI] [PubMed] [Google Scholar]
  6. Castroveijo R. Kontrolle der postoperativen Entzündung mit Fluorometholon. Klin Monbl Augenheilkd. 1975 Apr;166(4):518–520. [PubMed] [Google Scholar]
  7. Fairbairn W. D., Thorson J. C. Fluorometholone. Anti-inflammatory and intraocular pressure effects. Arch Ophthalmol. 1971 Aug;86(2):138–141. doi: 10.1001/archopht.1971.01000010140004. [DOI] [PubMed] [Google Scholar]
  8. GLENN E. M., MILLER W. L., SCHLAGEL C. A. METABOLIC EFFECTS OF ADRENOCORTICAL STEROIDS IN VIVO AND IN VITRO: RELATIONSHIP TO ANTI-INFLAMMATORY EFFECTS. Recent Prog Horm Res. 1963;19:107–199. [PubMed] [Google Scholar]
  9. MASS R. E. CLINICAL EVALUATION OF OXYLONE (NSC-33001). Cancer Chemother Rep. 1964 May;38:49–60. [PubMed] [Google Scholar]
  10. Mindel J. S., Tavitian H. O., Smith H., Jr, Walker E. C. Comparative ocular pressure elevation by medrysone, fluorometholone, and dexamethasone phosphate. Arch Ophthalmol. 1980 Sep;98(9):1577–1578. doi: 10.1001/archopht.1980.01020040429006. [DOI] [PubMed] [Google Scholar]
  11. POSTHUMUS R. G. [The use and the possibilities of progesterone in the treatment of glaucoma]. Ophthalmologica. 1952 Jul;124(1):17–25. doi: 10.1159/000301245. [DOI] [PubMed] [Google Scholar]
  12. SCHLAGEL C. A., NORTHAM J. I. Comparative anti-inflammatory efficacy of topically applied steriods on human skin. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:629–632. doi: 10.3181/00379727-101-25041. [DOI] [PubMed] [Google Scholar]
  13. Stewart R. H., Kimbrough R. L. Intraocular pressure response to topically administered fluorometholone. Arch Ophthalmol. 1979 Nov;97(11):2139–2140. doi: 10.1001/archopht.1979.01020020457010. [DOI] [PubMed] [Google Scholar]

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