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. 1986 Jun;70(6):435–438. doi: 10.1136/bjo.70.6.435

Oral acyclovir (Zovirax) in herpes simplex dendritic corneal ulceration.

L M Collum, P McGettrick, J Akhtar, J Lavin, P J Rees
PMCID: PMC1041036  PMID: 3521717

Abstract

Sixty patients with simple dendritic corneal ulceration were randomly assigned to double blind treatment with either acyclovir tablets (400 mg) or acyclovir ophthalmic ointment administered five times daily. There was no significant difference in the proportions of patients healed in either treatment group (88.9% on oral acyclovir and 96.6% on acyclovir ointment). The median healing time was five days in both groups. No systemic or significant local side effects were noted in either treatment group. Trough levels of acyclovir in the tear fluid of those who received the oral preparation were within or above the range of mean in-vitro ID50 levels for herpes simplex virus type 1. We conclude that oral administration of acyclovir (400 mg, five times daily) may be an effective alternative to topical therapy in selected patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colin J., Tournoux A., Chastel C., Renard G. Kératite herpétique superficielle. Traitement comparatif en double insu par acycloriv et idoxuridine. Nouv Presse Med. 1981 Oct 10;10(36):2969-70, 2975. [PubMed] [Google Scholar]
  2. Collins P. The spectrum of antiviral activities of acyclovir in vitro and in vivo. J Antimicrob Chemother. 1983 Sep;12 (Suppl B):19–27. doi: 10.1093/jac/12.suppl_b.19. [DOI] [PubMed] [Google Scholar]
  3. Collum L. M., Benedict-Smith A., Hillary I. B. Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration. Br J Ophthalmol. 1980 Oct;64(10):766–769. doi: 10.1136/bjo.64.10.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coster D. J., Wilhelmus K. R., Michaud R., Jones B. R. A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis. Br J Ophthalmol. 1980 Oct;64(10):763–765. doi: 10.1136/bjo.64.10.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elion G. B., Furman P. A., Fyfe J. A., de Miranda P., Beauchamp L., Schaeffer H. J. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716–5720. doi: 10.1073/pnas.74.12.5716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hung S. O., Patterson A., Rees P. J. Pharmacokinetics of oral acyclovir (Zovirax) in the eye. Br J Ophthalmol. 1984 Mar;68(3):192–195. doi: 10.1136/bjo.68.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones B. R., Coster D. J., Fison P. N., Thompson G. M., Cobo L. M., Falcon M. G. Efficacy of acycloguanosine (Wellcome 248U) against herpes-simplex corneal ulcers. Lancet. 1979 Feb 3;1(8110):243–244. doi: 10.1016/s0140-6736(79)90769-4. [DOI] [PubMed] [Google Scholar]
  8. Klauber A., Ottovay E. Acyclovir and idoxiuridine treatment of herpes simplex keratitis--a double blind clinical study. Acta Ophthalmol (Copenh) 1982 Oct;60(5):838–844. doi: 10.1111/j.1755-3768.1982.tb06748.x. [DOI] [PubMed] [Google Scholar]
  9. Laibson P. R., Pavan-Langston D., Yeakley W. R., Lass J. Acyclovir and vidarabine for the treatment of herpes simplex keratitis. Am J Med. 1982 Jul 20;73(1A):281–285. doi: 10.1016/0002-9343(82)90106-1. [DOI] [PubMed] [Google Scholar]
  10. McCulley J. P., Binder P. S., Kaufman H. E., O'Day D. M., Poirier R. H. A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis. Ophthalmology. 1982 Oct;89(10):1195–1200. doi: 10.1016/s0161-6420(82)34668-0. [DOI] [PubMed] [Google Scholar]
  11. McGill J., Tormey P., Walker C. B. Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers. Br J Ophthalmol. 1981 Sep;65(9):610–613. doi: 10.1136/bjo.65.9.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schaeffer H. J., Beauchamp L., de Miranda P., Elion G. B., Bauer D. J., Collins P. 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature. 1978 Apr 13;272(5654):583–585. doi: 10.1038/272583a0. [DOI] [PubMed] [Google Scholar]
  13. Whitley R. J., Blum M. R., Barton N., de Miranda P. Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals. Am J Med. 1982 Jul 20;73(1A):165–171. doi: 10.1016/0002-9343(82)90084-5. [DOI] [PubMed] [Google Scholar]
  14. Young B. J., Patterson A., Ravenscroft T. A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration. Br J Ophthalmol. 1982 Jun;66(6):361–363. doi: 10.1136/bjo.66.6.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. la Lau C., Oosterhuis J. A., Versteeg J., van Rij G., Renardel de Lavalette J. G., Craandijk A., Lamers W. P., Lamers W. P. Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial. Br J Ophthalmol. 1982 Aug;66(8):506–508. doi: 10.1136/bjo.66.8.506. [DOI] [PMC free article] [PubMed] [Google Scholar]

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