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. 1988 Mar;72(3):176–182. doi: 10.1136/bjo.72.3.176

Localising patterns of optic nerve hypoplasia--retina to occipital lobe.

P Novakovic 1, D S Taylor 1, W F Hoyt 1
PMCID: PMC1041401  PMID: 3355804

Abstract

Six cases are presented which provide clinical evidence that optic nerve hypoplasia can occur as a result of a lesion at any site in the developing visual system. The mechanisms of hypoplasia are discussed in the light of recent understanding of optic nerve development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acers T. E. Optic nerve hypoplasia: septo-optic-pituitary dysplasia syndrome. Trans Am Ophthalmol Soc. 1981;79:425–457. [PMC free article] [PubMed] [Google Scholar]
  2. Billson F., Hopkins I. J. Optic hypoplasia and hypopituitarism. Lancet. 1972 Apr 22;1(7756):905–905. doi: 10.1016/s0140-6736(72)90779-9. [DOI] [PubMed] [Google Scholar]
  3. Boniuk V., Ho P. K. Ocular findings in anencephaly. Am J Ophthalmol. 1979 Sep;88(3 Pt 2):613–617. doi: 10.1016/0002-9394(79)90524-5. [DOI] [PubMed] [Google Scholar]
  4. Brook C. G., Sanders M. D., Hoare R. D. Septo-optic dysplasia. Br Med J. 1972 Sep 30;3(5830):811–813. doi: 10.1136/bmj.3.5830.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown G. C. Optic nerve hypoplasia and colobomatous defects. J Pediatr Ophthalmol Strabismus. 1982 Mar-Apr;19(2):90–93. doi: 10.3928/0191-3913-19820301-06. [DOI] [PubMed] [Google Scholar]
  6. Edwards W. C., Layden W. E. Optic nerve hypoplasia. Am J Ophthalmol. 1970 Dec;70(6):950–959. doi: 10.1016/0002-9394(70)92474-8. [DOI] [PubMed] [Google Scholar]
  7. Ellenberger C., Jr, Runyan T. E. Holoprosencephaly with hypoplasia of the optic nerves, dwarfism, and agenesis of the septum pellucidum. Am J Ophthalmol. 1970 Dec;70(6):960–967. doi: 10.1016/0002-9394(70)92475-x. [DOI] [PubMed] [Google Scholar]
  8. Ewald R. A. Unilateral hypoplasia of the optic nerve. Radiologic and electroretinographic findings. Am J Ophthalmol. 1967 Apr;63(4):763–767. doi: 10.1016/0002-9394(67)91303-7. [DOI] [PubMed] [Google Scholar]
  9. Frisén L., Holmegaard L. Spectrum of optic nerve hypoplasia. Br J Ophthalmol. 1978 Jan;62(1):7–15. doi: 10.1136/bjo.62.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greenfield P. S., Wilcox L. M., Jr, Weiter J. J., Adelman L. Hypoplasia of the optic nerve in association with porencephaly. J Pediatr Ophthalmol Strabismus. 1980 Mar-Apr;17(2):75–80. doi: 10.3928/0191-3913-19800301-05. [DOI] [PubMed] [Google Scholar]
  11. Hackenbruch Y., Meerhoff E., Besio R., Cardoso H. Familial bilateral optic nerve hypoplasia. Am J Ophthalmol. 1975 Feb;79(2):314–320. doi: 10.1016/0002-9394(75)90088-4. [DOI] [PubMed] [Google Scholar]
  12. Harris R. J., Haas L. Septo-optic dysplasia with growth hormone deficiency (De Morsier syndrome). Arch Dis Child. 1972 Dec;47(256):973–976. doi: 10.1136/adc.47.256.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hittner H. M., Desmond M. M., Montgomery J. R. Optic nerve manifestations of human congenital cytomegalovirus infection. Am J Ophthalmol. 1976 May;81(5):661–665. doi: 10.1016/0002-9394(76)90134-3. [DOI] [PubMed] [Google Scholar]
  14. Holt C. E. The topography of the initial retinotectal projection. Prog Brain Res. 1983;58:339–345. doi: 10.1016/S0079-6123(08)60035-7. [DOI] [PubMed] [Google Scholar]
  15. Hotchkiss M. L., Green W. R. Optic nerve aplasia and hypoplasia. J Pediatr Ophthalmol Strabismus. 1979 Jul-Aug;16(4):225–240. doi: 10.3928/0191-3913-19790701-06. [DOI] [PubMed] [Google Scholar]
  16. Hoyt C. S., Billson F. A. Maternal anticonvulsants and optic nerve hypoplasia. Br J Ophthalmol. 1978 Jan;62(1):3–6. doi: 10.1136/bjo.62.1.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hoyt W. F., Kaplan S. L., Grumbach M. M., Glaser J. S. Septo-optic dysplasia and pituitary dwarfism. Lancet. 1970 Apr 25;1(7652):893–894. doi: 10.1016/s0140-6736(70)91717-4. [DOI] [PubMed] [Google Scholar]
  18. Hoyt W. F., Rios-Montenegro E. N., Behrens M. M., Eckelhoff R. J. Homonymous hemioptic hypoplasia. Fundoscopic features in standard and red-free illumination in three patients with congenital hemiplegia. Br J Ophthalmol. 1972 Jul;56(7):537–545. doi: 10.1136/bjo.56.7.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Jensen P. E., Kalina R. E. Congenital anomalies of the optic disk. Am J Ophthalmol. 1976 Jul;82(1):27–31. doi: 10.1016/0002-9394(76)90660-7. [DOI] [PubMed] [Google Scholar]
  20. KUPFER C. RETINAL GANGLION CELL DEGENERATION FOLLOWING CHIASMAL LESIONS IN MAN. Arch Ophthalmol. 1963 Aug;70:256–260. doi: 10.1001/archopht.1963.00960050258020. [DOI] [PubMed] [Google Scholar]
  21. KYTILA J., MIETTINEN P. On bilateral aplasia of the optic nerve. Acta Ophthalmol (Copenh) 1961;39:416–419. doi: 10.1111/j.1755-3768.1961.tb00869.x. [DOI] [PubMed] [Google Scholar]
  22. Keltner J. L., Gittinger J. W., Jr, Miller N. R., Burde R. M. The disc that really isn't (hypoplastic disc syndrome) Surv Ophthalmol. 1985 Mar-Apr;29(5):349–354. doi: 10.1016/0039-6257(85)90110-9. [DOI] [PubMed] [Google Scholar]
  23. Krause-Brucker W., Gardner D. W. Optic nerve hypoplasia associated with absent septum pellucidum and hypopituitarism. Am J Ophthalmol. 1980 Jan;89(1):113–120. doi: 10.1016/0002-9394(80)90237-8. [DOI] [PubMed] [Google Scholar]
  24. Kurz G. H., Ogata J., Gross E. M. Traumatic optic pathway degeneration. Antegrade and retrograde. Br J Ophthalmol. 1971 Apr;55(4):233–242. doi: 10.1136/bjo.55.4.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Layman P. R., Anderson D. R., Flynn J. T. Frequent occurrence of hypoplastic optic disks in patients with aniridia. Am J Ophthalmol. 1974 Apr;77(4):513–516. doi: 10.1016/0002-9394(74)90464-4. [DOI] [PubMed] [Google Scholar]
  26. Little L. E., Whitmore P. V., Wells T. W., Jr Aplasia of the optic nerve. J Pediatr Ophthalmol. 1976 Mar;13(2):84–88. [PubMed] [Google Scholar]
  27. Macoul K. L., Dellaporta A., Miller L. C. Hypoplasia of the optic nerve. Br J Ophthalmol. 1969 Jul;53(7):496–497. doi: 10.1136/bjo.53.7.496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Margalith D., Jan J. E., McCormick A. Q., Tze W. J., Lapointe J. Clinical spectrum of congenital optic nerve hypoplasia: review of 51 patients. Dev Med Child Neurol. 1984 Jun;26(3):311–322. doi: 10.1111/j.1469-8749.1984.tb04447.x. [DOI] [PubMed] [Google Scholar]
  29. McKinna A. J. Quinine induced hypoplasia of the optic nerve. Can J Ophthalmol. 1966 Oct;1(4):261–266. [PubMed] [Google Scholar]
  30. Mosier M. A., Lieberman M. F., Green W. R., Knox D. L. Hypoplasia of the optic nerve. Arch Ophthalmol. 1978 Aug;96(8):1437–1442. doi: 10.1001/archopht.1978.03910060185017. [DOI] [PubMed] [Google Scholar]
  31. Patel H., Tze W. J., Crichton J. U., McCormick A. Q., Robinson G. C., Dolman C. L. Optic nerve hypoplasia with hypopituitarism. Septo-optic dysplasia with hypopituitarism. Am J Dis Child. 1975 Feb;129(2):175–180. doi: 10.1001/archpedi.1975.02120390017004. [DOI] [PubMed] [Google Scholar]
  32. Petersen R. A., Walton D. S. Optic nerve hypoplasia with good visual acuity and visual field defects: a study of children of diabetic mothers. Arch Ophthalmol. 1977 Feb;95(2):254–258. doi: 10.1001/archopht.1977.04450020055011. [DOI] [PubMed] [Google Scholar]
  33. Quigley H. A., Davis E. B., Anderson D. R. Descending optic nerve degeneration in primates. Invest Ophthalmol Vis Sci. 1977 Sep;16(9):841–849. [PubMed] [Google Scholar]
  34. Rager G. Structural analysis of fiber organization during development. Prog Brain Res. 1983;58:313–319. doi: 10.1016/S0079-6123(08)60033-3. [DOI] [PubMed] [Google Scholar]
  35. Rogers G. L., Brown D., Gray I., Bremer D. Bilateral optic nerve hypoplasia associated with cerebral atrophy. J Pediatr Ophthalmol Strabismus. 1981 Nov-Dec;18(6):18–22. doi: 10.3928/0191-3913-19811101-06. [DOI] [PubMed] [Google Scholar]
  36. Seeley R. L., Smith J. L. Visual field defects in optic nerve hypoplasia. Am J Ophthalmol. 1972 Jun;73(6):882–889. doi: 10.1016/0002-9394(72)90457-6. [DOI] [PubMed] [Google Scholar]
  37. Silver J., Sidman R. L. A mechanism for the guidance and topographic patterning of retinal ganglion cell axons. J Comp Neurol. 1980 Jan 1;189(1):101–111. doi: 10.1002/cne.901890106. [DOI] [PubMed] [Google Scholar]
  38. Silver J. Studies on the factors that govern directionality of axonal growth in the embryonic optic nerve and at the chiasm of mice. J Comp Neurol. 1984 Feb 20;223(2):238–251. doi: 10.1002/cne.902230207. [DOI] [PubMed] [Google Scholar]
  39. Skarf B., Hoyt C. S. Optic nerve hypoplasia in children. Association with anomalies of the endocrine and CNS. Arch Ophthalmol. 1984 Jan;102(1):62–67. doi: 10.1001/archopht.1984.01040030046032. [DOI] [PubMed] [Google Scholar]
  40. Taylor D. Congenital tumours of the anterior visual system with dysplasia of the optic discs. Br J Ophthalmol. 1982 Jul;66(7):455–463. doi: 10.1136/bjo.66.7.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Van Dyk H. J., Morgan K. S. Optic nerve hypoplasia and young maternal age. Am J Ophthalmol. 1980 Jun;89(6):879–879. doi: 10.1016/0002-9394(80)90189-0. [DOI] [PubMed] [Google Scholar]
  42. WHINERY R. D., BLODI F. C. HYPOPLASIA OF THE OPTIC NERVE--A CLINICAL AND HISTOPATHOLOGIC CORRELATION. Trans Am Acad Ophthalmol Otolaryngol. 1963 Sep-Oct;67:733–738. [PubMed] [Google Scholar]
  43. Walton D. S., Robb R. M. Optic nerve hypoplasia. A report of 20 cases. Arch Ophthalmol. 1970 Nov;84(5):572–578. doi: 10.1001/archopht.1970.00990040574003. [DOI] [PubMed] [Google Scholar]
  44. Weiter J. J., McLean I. W., Zimmerman L. E. Aplasia of the optic nerve and disk. Am J Ophthalmol. 1977 Apr;83(4):569–576. doi: 10.1016/0002-9394(77)90569-4. [DOI] [PubMed] [Google Scholar]
  45. Yanoff M., Rorke L. B., Allman M. I. Bilateral optic system aplasia with relatively normal eyes. Arch Ophthalmol. 1978 Jan;96(1):97–101. doi: 10.1001/archopht.1978.03910050053013. [DOI] [PubMed] [Google Scholar]
  46. Young S. E., Walsh F. B., Knox D. L. The tilted disk syndrome. Am J Ophthalmol. 1976 Jul;82(1):16–23. doi: 10.1016/0002-9394(76)90658-9. [DOI] [PubMed] [Google Scholar]

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