Abstract
Sera obtained from 26 patients with Fuchs' heterochromic cyclitis were examined for the presence of autoantibodies directed against the anterior segment of the eye by means of immunofluorescence techniques. Antibodies against human iris tissue could not be detected, whereas autoantibodies against corneal epithelium were found in almost 90% of cases. This is the first report describing the presence of autoantibodies in patients with Fuchs' heterochromic cyclitis and it provides a further clue that immunological mechanisms might play an important role in the aetiology of Fuchs' heterochromic cyclitis.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brinkman C. J., Oerlemans-van Zutphen M. P., Broekhuyse R. M. Ocular antigens IX. Demonstration of common antigenicity in corneal epithelium and other tissues of the bovine eye. Exp Eye Res. 1978 Jul;27(1):81–86. doi: 10.1016/0014-4835(78)90055-6. [DOI] [PubMed] [Google Scholar]
- Dernouchamps J. P. The proteins of the aqueous humour. Doc Ophthalmol. 1982 Nov 1;53(3):193–248. doi: 10.1007/BF00140422. [DOI] [PubMed] [Google Scholar]
- Dernouchamps J. P., Vaerman J. P., Michiels J., Masson P. L. Immune complexes in the aqueous humor and serum. Am J Ophthalmol. 1977 Jul;84(1):24–31. doi: 10.1016/0002-9394(77)90319-1. [DOI] [PubMed] [Google Scholar]
- Eype A. A., Kruit P. J., vd Gaag R., Neuteboom G. H., Broersma L., Kijlstra A. Autoimmunity against corneal antigens. II. Accessibility of the 54 kD corneal antigen for circulating antibodies. Curr Eye Res. 1987 Mar;6(3):467–475. doi: 10.3109/02713688709025203. [DOI] [PubMed] [Google Scholar]
- Goldberg M. F., Erozan Y. S., Duke J. R., Frost J. K. Cytopathologic and histopathologic aspects of Fuchs' heterochromic iridocyclitis. Arch Ophthalmol. 1965 Nov;74(5):604–609. doi: 10.1001/archopht.1965.00970040606004. [DOI] [PubMed] [Google Scholar]
- Kruit P. J., van der Gaag R., Broersma L., Kijlstra A. Autoimmunity against corneal antigens. I. Isolation of a soluble 54 Kd corneal epithelium antigen. Curr Eye Res. 1986 Apr;5(4):313–320. doi: 10.3109/02713688609020057. [DOI] [PubMed] [Google Scholar]
- Kruit P. J., van der Gaag R., Broersma L., Kijlstra A. Circulating antibodies to corneal epithelium in patients with uveitis. Br J Ophthalmol. 1985 Jun;69(6):446–448. doi: 10.1136/bjo.69.6.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCartney A. C., Bull T. B., Spalton D. J. Fuchs' heterochromic cyclitis: an electron microscopy study. Trans Ophthalmol Soc U K. 1986;105(Pt 3):324–329. [PubMed] [Google Scholar]
- Murray P. Serum autoantibodies and uveitis. Br J Ophthalmol. 1986 Apr;70(4):266–268. doi: 10.1136/bjo.70.4.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Connor G. R. Doyne lecture. Heterochromic iridocyclitis. Trans Ophthalmol Soc U K. 1985;104(Pt 3):219–231. [PubMed] [Google Scholar]
- Perry H. D., Yanoff M., Scheie H. G. Rubeosis in Fuchs heterochromic iridocyclitis. Arch Ophthalmol. 1975 May;93(5):337–339. doi: 10.1001/archopht.1975.01010020349005. [DOI] [PubMed] [Google Scholar]
- Silverman B., Alexander R. J., Henley W. L. Tissue and species specificity of BCP 54, the major soluble protein of bovine cornea. Exp Eye Res. 1981 Jul;33(1):19–29. doi: 10.1016/s0014-4835(81)80078-4. [DOI] [PubMed] [Google Scholar]
- Waldrep J. C. Uveal IgG distribution: regulation by electrostatic interactions. Curr Eye Res. 1987 Jul;6(7):897–907. doi: 10.3109/02713688709034858. [DOI] [PubMed] [Google Scholar]
- Whiteside T. L., Hamada S., Manski W. J. Immunochemical analysis of tissue antigens in different corneal layers and sclera. Exp Eye Res. 1973 Sep;16(6):413–420. doi: 10.1016/0014-4835(73)90098-5. [DOI] [PubMed] [Google Scholar]
- Wobmann P. Die heterochromiecyclitis Fuchs. Elektronenmikroskopische Studie von 9 Irisbiopsien. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Apr 14;199(2):167–178. doi: 10.1007/BF02385213. [DOI] [PubMed] [Google Scholar]