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. 1991 Oct;75(10):611–614. doi: 10.1136/bjo.75.10.611

Ocular complications of bone marrow transplantation.

L C Bray 1, P J Carey 1, S J Proctor 1, R G Evans 1, P J Hamilton 1
PMCID: PMC1042498  PMID: 1954211

Abstract

Forty-one patients who had undergone bone marrow transplantation were examined. Nineteen (63%) of the 30 who had received fractionated total body irradiation (TBI) had cataracts in comparison with only 1 (9%) of the 11 non-irradiated patients. No significant differences in steroid therapy were demonstrated between these groups of patients. Dry eyes were observed in eight irradiated patients, seven of whom had preceding graft-versus-host disease. Superficial punctate staining of the bulbar conjunctiva was observed in 25 (83%) of the irradiated group and, in milder form, in five (45%) of the non-irradiated group. Our data suggest that the incidence of cataract following fractionated TBI is influenced not only by the total dose of radiation but also by its rate of administration (defined by midline tissue dose rate and fractionation schedule). In addition dry eyes and conjunctival staining may be exacerbated by TBI, though other aspects of conditioning may also be implicated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLACK R. L., OGLESBY R. B., VON SALLMANN L., BUNIM J. J. Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis. JAMA. 1960 Sep 10;174:166–171. doi: 10.1001/jama.1960.63030020005014. [DOI] [PubMed] [Google Scholar]
  2. Deeg H. J., Flournoy N., Sullivan K. M., Sheehan K., Buckner C. D., Sanders J. E., Storb R., Witherspoon R. P., Thomas E. D. Cataracts after total body irradiation and marrow transplantation: a sparing effect of dose fractionation. Int J Radiat Oncol Biol Phys. 1984 Jul;10(7):957–964. doi: 10.1016/0360-3016(84)90163-9. [DOI] [PubMed] [Google Scholar]
  3. Franklin R. M., Kenyon K. R., Tutschka P. J., Saral R., Green W. R., Santos G. W. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983 Jan;90(1):4–13. doi: 10.1016/s0161-6420(83)34604-2. [DOI] [PubMed] [Google Scholar]
  4. Hirst L. W., Jabs D. A., Tutschka P. J., Green W. R., Santos G. W. The eye in bone marrow transplantation. I. Clinical study. Arch Ophthalmol. 1983 Apr;101(4):580–584. doi: 10.1001/archopht.1983.01040010580010. [DOI] [PubMed] [Google Scholar]
  5. Hoover D. L., Smith L. E., Turner S. J., Gelber R. D., Sallan S. E. Ophthalmic evaluation of survivors of acute lymphoblastic leukemia. Ophthalmology. 1988 Feb;95(2):151–155. doi: 10.1016/s0161-6420(88)33198-2. [DOI] [PubMed] [Google Scholar]
  6. Jack M. K., Jack G. M., Sale G. E., Shulman H. M., Sullivan K. M. Ocular manifestations of graft-v-host disease. Arch Ophthalmol. 1983 Jul;101(7):1080–1084. doi: 10.1001/archopht.1983.01040020082014. [DOI] [PubMed] [Google Scholar]
  7. Lawley T. J., Peck G. L., Moutsopoulos H. M., Gratwohl A. A., Deisseroth A. B. Scleroderma, Sjögren-like syndrome, and chronic graft-versus-host disease. Ann Intern Med. 1977 Dec;87(6):707–709. doi: 10.7326/0003-4819-87-6-707. [DOI] [PubMed] [Google Scholar]
  8. Livesey S. J., Holmes J. A., Whittaker J. A. Ocular complications of bone marrow transplantation. Eye (Lond) 1989;3(Pt 3):271–276. doi: 10.1038/eye.1989.37. [DOI] [PubMed] [Google Scholar]
  9. MERRIAM G. R., Jr, FOCHT E. F. A clinical study of radiation cataracts and the relationship to dose. Am J Roentgenol Radium Ther Nucl Med. 1957 May;77(5):759–785. [PubMed] [Google Scholar]
  10. Parsons J. T., Fitzgerald C. R., Hood C. I., Ellingwood K. E., Bova F. J., Million R. R. The effects of irradiation on the eye and optic nerve. Int J Radiat Oncol Biol Phys. 1983 May;9(5):609–622. doi: 10.1016/0360-3016(83)90225-0. [DOI] [PubMed] [Google Scholar]
  11. Sparrow J. M., Bron A. J., Brown N. A., Ayliffe W., Hill A. R. The Oxford Clinical Cataract Classification and Grading System. Int Ophthalmol. 1986 Dec;9(4):207–225. doi: 10.1007/BF00137534. [DOI] [PubMed] [Google Scholar]
  12. Sullivan K. M., Shulman H. M., Storb R., Weiden P. L., Witherspoon R. P., McDonald G. B., Schubert M. M., Atkinson K., Thomas E. D. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood. 1981 Feb;57(2):267–276. [PubMed] [Google Scholar]
  13. Thomas E., Storb R., Clift R. A., Fefer A., Johnson F. L., Neiman P. E., Lerner K. G., Glucksberg H., Buckner C. D. Bone-marrow transplantation (first of two parts). N Engl J Med. 1975 Apr 17;292(16):832–843. doi: 10.1056/NEJM197504172921605. [DOI] [PubMed] [Google Scholar]

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