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. 1978 Mar;62(3):145–154. doi: 10.1136/bjo.62.3.145

Effects of ultrasound on the corneal endothelium: II. The endothelial repair process.

L E Olson, J Marshall, N S Rice, R Andrews
PMCID: PMC1043168  PMID: 638105

Abstract

The responses of corneal endothelium to a 2-minute exposure of ultrasound from a clinical phacoemulsification device have been studied by specular microscopy and both scanning and transmission electron microscope. Healing of lesions occurred in two ways, and these were related to lesion size. Small lesions healed by a process of rosette formation, and large lesions were repaired by a process of endothelial dedifferentiation and migration. All damaged areas were re-covered with endothelial cells within 24 hours of exposure, and at this time corneal thickness had returned to control levels. The implications are discussed in relation to the phacoemulsification procedure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binder P. S., Sternberg H., Wickman M. G., Worthen D. M. Corneal endothelial damage associated with phacoemulsification. Am J Ophthalmol. 1976 Jul;82(1):48–54. doi: 10.1016/0002-9394(76)90663-2. [DOI] [PubMed] [Google Scholar]
  2. Bourne W. M., Kaufman H. E. Endothelial damage associated with intraocular lenses. Am J Ophthalmol. 1976 Apr;81(4):482–485. doi: 10.1016/0002-9394(76)90305-6. [DOI] [PubMed] [Google Scholar]
  3. Capella J. A. Regeneration of endothelium in diseased and injured corneas. Am J Ophthalmol. 1972 Nov;74(5):810–817. doi: 10.1016/0002-9394(72)91200-7. [DOI] [PubMed] [Google Scholar]
  4. Cleasby G. W., Fung W. E., Webster R. G., Jr The lens fragmentation and aspiration procedure (phacoemulsification). Am J Ophthalmol. 1974 Mar;77(3):384–387. doi: 10.1016/0002-9394(74)90745-4. [DOI] [PubMed] [Google Scholar]
  5. Hiles D. A., Hurite F. G. Results of the first year's experience with phaco-emulsification. Am J Ophthalmol. 1973 Mar;75(3):473–477. doi: 10.1016/0002-9394(73)91159-8. [DOI] [PubMed] [Google Scholar]
  6. Hodson S., Miller F. The bicarbonate ion pump in the endothelium which regulates the hydration of rabbit cornea. J Physiol. 1976 Dec;263(3):563–577. doi: 10.1113/jphysiol.1976.sp011645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Laing R. A., Sanstrom M. M., Berrospi A. R., Leibowitz H. M. Changes in the corneal endothelium as a function of age. Exp Eye Res. 1976 Jun;22(6):587–594. doi: 10.1016/0014-4835(76)90003-8. [DOI] [PubMed] [Google Scholar]
  8. Leibowitz H. M., Laing R. A., Sandstrom M. Corneal endothelium. Arch Ophthalmol. 1974 Sep;92(3):227–230. doi: 10.1001/archopht.1974.01010010235012. [DOI] [PubMed] [Google Scholar]
  9. Matsuda H., Smelser G. K. Endothelial cells in alkali-burned corneas. Ultrastructural alterations. Arch Ophthalmol. 1973 May;89(5):402–409. doi: 10.1001/archopht.1973.01000040404010. [DOI] [PubMed] [Google Scholar]
  10. Maurice D. M. Cellular membrane activity in the corneal endothelium of the intact eye. Experientia. 1968 Nov 15;24(11):1094–1095. doi: 10.1007/BF02147776. [DOI] [PubMed] [Google Scholar]
  11. McCarey B. E., Polack F. M., Marshall W. The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium. Invest Ophthalmol. 1976 Jun;15(6):449–457. [PubMed] [Google Scholar]
  12. OH J. O., EVANS C. A. Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80. Virology. 1960 Jan;10:127–143. doi: 10.1016/0042-6822(60)90011-8. [DOI] [PubMed] [Google Scholar]
  13. Olson L. E., Marshall J., Rice N. S., Andrews R. Effects of ultrasound on the corneal endothelium: I. The acute lesion. Br J Ophthalmol. 1978 Mar;62(3):134–144. doi: 10.1136/bjo.62.3.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Polack F. M., Sugar A. The phacoemulsification procedure. II. Corneal endothelial changes. Invest Ophthalmol. 1976 Jun;15(6):458–469. [PubMed] [Google Scholar]
  15. Sanchez J., Polack F. M. Effect of topical steroids on the healing of corneal endothelium. Invest Ophthalmol. 1974 Jan;13(1):17–22. [PubMed] [Google Scholar]
  16. Sherrard E. S. The corneal endothelium in vivo: its response to mild trauma. Exp Eye Res. 1976 Apr;22(4):347–357. doi: 10.1016/0014-4835(76)90227-x. [DOI] [PubMed] [Google Scholar]
  17. Van Horn D. L., Sendele D. D., Seideman S., Buco P. J. Regenerative capacity of the corneal endothelium in rabbit and cat. Invest Ophthalmol Vis Sci. 1977 Jul;16(7):597–613. [PubMed] [Google Scholar]

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