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. 1979 Mar;63(3):191–194. doi: 10.1136/bjo.63.3.191

Optic neuropathy in ketogenic diet.

C S Hoyt, F A Billson
PMCID: PMC1043439  PMID: 435431

Abstract

A symmetrical, bilateral optic neuropathy is reported in 2 patients being treated with ketogenic diets for seizure control. Laboratory tests suggested a thiamine deficiency, and both patients recovered normal visual function after several weeks of treatment with thiamine. The risk of optic nerve dysfunction occurring during the treatment with a ketogenic diet can be minimised if routine vitamin B supplements are given and periodic evaluation of optic nerve function undertaken.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COGAN D. G., VICTOR M. Ocular signs of Wernicke's disease. AMA Arch Ophthalmol. 1954 Feb;51(2):204–211. doi: 10.1001/archopht.1954.00920040206007. [DOI] [PubMed] [Google Scholar]
  2. DeVivo D. C., Pagliara A. S., Prensky A. L. Ketotic hypoglycemia and the ketogenic diet. Neurology. 1973 Jun;23(6):640–649. doi: 10.1212/wnl.23.6.640. [DOI] [PubMed] [Google Scholar]
  3. Dekaban A. S. Plasma lipids in epileptic children treated with the high fat diet. Arch Neurol. 1966 Aug;15(2):177–184. doi: 10.1001/archneur.1966.00470140067009. [DOI] [PubMed] [Google Scholar]
  4. Dodson W. E., Prensky A. L., DeVivo D. C., Goldring S., Dodge P. R. Management of seizure disorders: selected aspects. Part II. J Pediatr. 1976 Nov;89(5):695–703. doi: 10.1016/s0022-3476(76)80786-x. [DOI] [PubMed] [Google Scholar]
  5. Dreyfus P. M. Blood transketolase levels in tobacco-alcohol amblyopia. Arch Ophthalmol. 1965 Nov;74(5):617–620. doi: 10.1001/archopht.1965.00970040619006. [DOI] [PubMed] [Google Scholar]
  6. Gordon N. Medium-chain triglycerides in a ketogenic diet. Dev Med Child Neurol. 1977 Aug;19(4):535–538. doi: 10.1111/j.1469-8749.1977.tb07951.x. [DOI] [PubMed] [Google Scholar]
  7. Hoyt C. S., 3rd, Billson F. A. Low-carbohydrate diet optic neuropathy. Med J Aust. 1977 Jan 15;1(3):65–66. doi: 10.5694/j.1326-5377.1977.tb130506.x. [DOI] [PubMed] [Google Scholar]
  8. Huttenlocher P. R. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res. 1976 May;10(5):536–540. doi: 10.1203/00006450-197605000-00006. [DOI] [PubMed] [Google Scholar]
  9. Huttenlocher P. R., Wilbourn A. J., Signore J. M. Medium-chain triglycerides as a therapy for intractable childhood epilepsy. Neurology. 1971 Nov;21(11):1097–1103. doi: 10.1212/wnl.21.11.1097. [DOI] [PubMed] [Google Scholar]
  10. Kraus H., Schlenker S., Schwedesky D. Developmental changes of cerebral ketone body utilization in human infants. Hoppe Seylers Z Physiol Chem. 1974 Feb;355(2):164–170. doi: 10.1515/bchm2.1974.355.1.164. [DOI] [PubMed] [Google Scholar]
  11. Owen O. E., Morgan A. P., Kemp H. G., Sullivan J. M., Herrera M. G., Cahill G. F., Jr Brain metabolism during fasting. J Clin Invest. 1967 Oct;46(10):1589–1595. doi: 10.1172/JCI105650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Patel H., Crichton J. U. The neurologic hazards of diphenylhydantoin in childhood. J Pediatr. 1968 Nov;73(5):676–684. doi: 10.1016/s0022-3476(68)80172-6. [DOI] [PubMed] [Google Scholar]
  13. RODGER F. C. Experimental thiamin deficiency as a cause of degeneration in the visual pathway of the rat. Br J Ophthalmol. 1953 Jan;37(1):11–29. doi: 10.1136/bjo.37.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Signore J. M. Ketogenic diet containing medium-chain triglycerides. J Am Diet Assoc. 1973 Mar;62(3):285–290. [PubMed] [Google Scholar]

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