Skip to main content
PMC home page
The British Journal of Venereal Diseases logoLink to The British Journal of Venereal Diseases
. 1973 Jun;49(3):277–290. doi: 10.1136/sti.49.3.277

Single-session treatment of uncomplicated gonorrhoea in men, using penicillin combined with cotrimoxazole. Controlled trial comparing four different treatment schedules with observations on antibiotic sensitivities of gonococci and a review of the literature.

A S Wigfield, J B Selkon, G E Rich
PMCID: PMC1044907  PMID: 4578213

Full text

PDF
290

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALERGANT C. D. TREATMENT OF GONORRHOEA WITH PENBRITIN. A REPORT OF 200 CASES. Br J Vener Dis. 1963 Dec;39:225–227. doi: 10.1136/sti.39.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Amies C. R. Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968. Br J Vener Dis. 1969 Sep;45(3):216–222. doi: 10.1136/sti.45.3.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Arya O. P., Pearson C. H., Rao S. K., Blowers R. Treatment of gonorrhoea with trimethoprim-sulphamethoxazole in Uganda. Br J Vener Dis. 1970 Jun;46(3):214–216. doi: 10.1136/sti.46.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BARRETT C. D., Jr, BURTON M. E. Chloromycetin treatment of gonorrhea; evaluation of a single oral dose administered to patients with acute gonorrheal urethritis. Am J Syph Gonorrhea Vener Dis. 1953 Mar;37(2):165–176. [PubMed] [Google Scholar]
  5. BUTLER P. G., BREWER A. F., CONDIT P. K., JOHNSTON J. Chloromycetin (chloramphenicol) and penicillin in gonorrheal urethritis; two effective single dose plans. Am J Syph Gonorrhea Vener Dis. 1952 May;36(3):269–271. [PubMed] [Google Scholar]
  6. Baytch H., Rankin D. W. Comparison of penicillin, tetracycline, and doxycycline in the treatment of uncomplicated gonorrhoea in men. Br J Vener Dis. 1972 Apr;48(2):129–132. doi: 10.1136/sti.48.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bro-Jorgensen A., Jensen T. Single-dose oral treatment of gonorrhea in men and women, using ampicillin alone and combined with probenecid. Br J Vener Dis. 1971 Dec;47(6):443–447. doi: 10.1136/sti.47.6.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cobbold R. J., Spitzer R. J., Morrison G. D., Willcox R. R. One-session treatment of gonorrhoea in males with procaine penicillin plus probenecid. Postgrad Med J. 1970 Mar;46(533):142–145. doi: 10.1136/pgmj.46.533.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cornelius C. E., 3rd, Domescik G. Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea. Br J Vener Dis. 1970 Jun;46(3):212–213. doi: 10.1136/sti.46.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Csonka G. W., Knight G. J. Therapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea. Br J Vener Dis. 1967 Sep;43(3):161–165. doi: 10.1136/sti.43.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Fluker J. L., Hewitt A. B. High dosage procaine penicillin combined with ampicillin in the treatment of gonorrhoea after failure with standard procaine penicillin dosage. Br J Vener Dis. 1969 Dec;45(4):317–320. doi: 10.1136/sti.45.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GREAVES A. B., MacDONALD G. R., ROMANSKY M. J., TAGGART S. R. Treatment of gonorrhea with chloramphenicol (chloromycetin). J Vener Dis Inf. 1950 Oct;31(10):261–262. [PubMed] [Google Scholar]
  14. Gray R. C., Phillips I., Nicol C. S. Treatment of gonorrhoea with three different antibiotic regimes: doxycycline 300 mg., procaine penicillin plus benzyl penicillin 2.4 m.u., benzyl penicillin 5 m.u. plus probenecid. Br J Vener Dis. 1970 Oct;46(5):401–403. doi: 10.1136/sti.46.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Groth O., Hallqvist L. Oral ampicillin in gonorrhoea. Clinical evaluation. Br J Vener Dis. 1970 Feb;46(1):21–26. doi: 10.1136/sti.46.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gundersen T., Odegaard K., Gjessing H. C. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined. Br J Vener Dis. 1969 Sep;45(3):235–237. doi: 10.1136/sti.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hewitt A. B. Significance of the "defaulter" in the assessment of efficiency of treatment in gonorrhoea. Br J Vener Dis. 1969 Mar;45(1):40–41. doi: 10.1136/sti.45.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Holmes K. K., Johnson D. W., Floyd T. M. Studies of venereal disease. I. Probenecid-procaine penicillin G combination and tetracycline hydrochloride in the treatment of "penicillin-resistant" gonorrhea in men. JAMA. 1967 Nov 6;202(6):461–473. doi: 10.1001/jama.202.6.461. [DOI] [PubMed] [Google Scholar]
  19. JAWETZ E., GUNNISON J. B. Antibiotic synergism and antagonism; an assessment of the problem. Pharmacol Rev. 1953 Jun;5(2):175–192. [PubMed] [Google Scholar]
  20. Jouhar A., Fowler W. Cephaloridine in gonorrhoea in females. Br J Vener Dis. 1968 Sep;44(3):223–225. doi: 10.1136/sti.44.3.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Keys T. F., Halverson C. W., Clarke E. J., Jr Single-dose treatment of gonorrhea with selected antibiotic agents. JAMA. 1969 Nov 3;210(5):857–861. [PubMed] [Google Scholar]
  22. LETCHNER E. H., NICOL C. S. A comparison of sensitivity to pencillin of N. gonorrhoeae, 1960 and 1958. Br J Vener Dis. 1961 Jun;37:158–160. doi: 10.1136/sti.37.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Leigh D. A., Le Franc J., Turnbull A. R. Sensitivity to penicillin of Neisseria gonorrhoeae. Relationship to the results of treatment. Br J Vener Dis. 1969 Jun;45(2):151–153. doi: 10.1136/sti.45.2.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lomholt G., Berg O. Gonorrhoea situation in South Greenland in the summer of 1964. Br J Vener Dis. 1966 Mar;42(1):1–7. doi: 10.1136/sti.42.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lynn R., Nicol C. S., Ridley M., Rimmer D., Symonds M. A., Warren C. Further studies of penicillin resistant gonococci. Br J Vener Dis. 1970 Oct;46(5):404–405. doi: 10.1136/sti.46.5.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Martin J. E., Jr, Lester A., Price E. V., Schmale J. D. Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969. J Infect Dis. 1970 Nov;122(5):459–461. doi: 10.1093/infdis/122.5.459. [DOI] [PubMed] [Google Scholar]
  27. Masterton G., Schofield C. B. Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonococcal and nonspecific urethritis in men. Br J Vener Dis. 1972 Apr;48(2):121–125. doi: 10.1136/sti.48.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. McLone D. G., Billings T. E., Hardegree W. E., Hackney J. F. Gonorrhoea in females treated with one oral dose of tetracycline. Br J Vener Dis. 1968 Sep;44(3):218–219. doi: 10.1136/sti.44.3.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. McLone D. G., Kiley J. D., Hackney J. F. Gonorrhoeal urethritis in males treated with one oral dose of oxytetracycline. Br J Vener Dis. 1967 Sep;43(3):166–167. doi: 10.1136/sti.43.3.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. McLone D. G., Scott A. T., Mackey D. M., Hackney J. F. Cephaloridine treatment of gonorrhoea in the female. Br J Vener Dis. 1968 Sep;44(3):220–222. doi: 10.1136/sti.44.3.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Moffett M., McGill M. I., Masterton G., Schofield C. B. Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonorrhoea in women. Br J Vener Dis. 1972 Apr;48(2):126–128. doi: 10.1136/sti.48.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Morrison G. D., Cobbold R. J., Bor S., Spitzer R. J., Foster D. N., Willcox R. R. Treatment of gonococcal urethritis with single injections of 2-4 mega units of aqueous procaine penicillin. Br J Vener Dis. 1968 Dec;44(4):319–323. doi: 10.1136/sti.44.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Moses J. M., Desai M. S., Bhosle C. B., Trasi M. S. Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay. Br J Vener Dis. 1971 Aug;47(4):273–278. doi: 10.1136/sti.47.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Nicol C. S., Ridley M., Symonds M. A. The problem of penicillin resistant gonococci. Br J Vener Dis. 1968 Dec;44(4):315–318. doi: 10.1136/sti.44.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Nicol C. S. Venereal disease in women. II. Br Med J. 1971 May 15;2(5758):383–384. doi: 10.1136/bmj.2.5758.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Odegaard K., Gjessing H. C. Is gonococcal sensitivity to antibiotics increasing in Norway? Br J Vener Dis. 1967 Dec;43(4):284–286. doi: 10.1136/sti.43.4.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Olsen G. A., Lomholt G. Gonorébehandling med kombineret probenecid og benzylnatriumpenicillin. En undersøgelse fra Grøland. Ugeskr Laeger. 1968 Sep 5;130(36):1465–1468. [PubMed] [Google Scholar]
  38. Ongom V. L. A 'single dose' treatment of gonococcal urethritis with rifampicin. Br J Vener Dis. 1971 Jun;47(3):188–189. doi: 10.1136/sti.47.3.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Rees E., Annels E. H. Gonococcal salpingitis. Br J Vener Dis. 1969 Sep;45(3):205–215. doi: 10.1136/sti.45.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Silver P. S., Darling W. M. Penicillin-insensitive gonococci in the Bolton area. Preponderance in young women and immigrants. Br J Vener Dis. 1971 Oct;47(5):367–372. doi: 10.1136/sti.47.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Smithurst B. A. Treatment of acute gonococcal urethritis with three drug regimes in 768 males, Brisbane, Queensland, 1967-69. Br J Vener Dis. 1970 Oct;46(5):398–400. doi: 10.1136/sti.46.5.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Wols-Van der Wielen A. Sensitivity to antibiotics of gonococcal strains isolated from sailors at Rotterdam. Br J Vener Dis. 1971 Jun;47(3):190–191. doi: 10.1136/sti.47.3.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Wright D. J., Grimble A. S. Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea. Br J Vener Dis. 1970 Feb;46(1):34–36. doi: 10.1136/sti.46.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Venereal Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES