Abstract
The results of a double-blind therapeutic trial on 81 men suffering from non-specific urethritis (NSU) show that minocycline was more effective than a placebo. Before treatment Chlamydia trachomatis was isolated from 31 per cent. of the men, ureaplasmas from 58 per cent., and Mycoplasma hominis from 7-5 per cent. There is evidence that chlamydiae are a cause of urethritis. However, after minocycline therapy improvement in the clinical response of patients from whom only ureaplasmas were isolated was less significant, so that the evidence that these organisms are pathogenic is less convincing. Possible reasons for this are discussed, as are the implications of finding minocycline-resistant ureaplasmas in at least 6 per cent. of the patients who harboured these organisms. The symptoms and signs of patients from whom micro-organisms were not isolated also improved after minocycline therapy, implying that the aetiological agents in this group of patients are antibiotic-sensitive. However, the results do not exclude the possibility that a minocycline-resistant agent is the cause of urethritis in a minority of patients.
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Selected References
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- Dunlop E. M., Vaughan-Jackson J. D., Darougar S. Chlamydial infection. Improved methods of collection of material for culture from the urogenital tract and rectum. Br J Vener Dis. 1972 Dec;48(6):421–424. doi: 10.1136/sti.48.6.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gourlay R. N., Howard C. J., Brownlie J. The production of mastitis in cows by the intramammary inoculation of T-mycoplasmas. J Hyg (Lond) 1972 Sep;70(3):511–521. doi: 10.1017/s0022172400063099. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harrison R. F., de Louvois J., Blades M., Hurley R. Doxycycline treatment and human infertility. Lancet. 1975 Mar 15;1(7907):605–607. doi: 10.1016/s0140-6736(75)91885-1. [DOI] [PubMed] [Google Scholar]
- Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
- Holmes K. K., Johnson D. W., Floyd T. M. Studies of venereal disease. 3. Double-blind comparison of tetracycline hydrochloride and placebo in treatment of nongonococcal urethritis. JAMA. 1967 Nov 6;202(6):474–476. doi: 10.1001/jama.202.6.474. [DOI] [PubMed] [Google Scholar]
- Macdonald H., Kelly R. G., Allen E. S., Noble J. F., Kanegis L. A. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):852–861. doi: 10.1002/cpt1973145852. [DOI] [PubMed] [Google Scholar]
- McCormack W. M., Braun P., Lee Y. H., Klein J. O., Kass E. H. The genital mycoplasmas. N Engl J Med. 1973 Jan 11;288(2):78–89. doi: 10.1056/NEJM197301112880206. [DOI] [PubMed] [Google Scholar]
- Oriel J. D., Reeve P., Powis P., Miller A., Nicol C. S. Chlamydial infection. Isolation of Chlamydia from patients with non-specific genital infection. Br J Vener Dis. 1972 Dec;48(6):429–436. doi: 10.1136/sti.48.6.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor-Robinson D., Addey J. P., Hare M. J., Dunlop E. M. Mycoplasmas and "non-specific" genital infection. I. Previous studies and laboratory aspects. Br J Vener Dis. 1969 Dec;45(4):265–273. doi: 10.1136/sti.45.4.265. [DOI] [PMC free article] [PubMed] [Google Scholar]