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. 1978 Feb;54(1):15–23. doi: 10.1136/sti.54.1.15

Diagnostic treatment and reporting criteria for gonorrhoea in sexually transmitted disease clinics in England and Wales. 2: treatment and reporting criteria.

M W Adler
PMCID: PMC1045464  PMID: 638713

Abstract

The current methods of treatment and reporting are described. The most common form of treatment for gonorrhoea in men and women was a single dose of oral ampicillin, usually 2 g. In proportionately more of the clinics treating women, treatment was given over several days. The wide use of ampicillin represents a marked change in treatment practice during the last decade. Procaine penicillin was the most commonly used parenteral preparation. The two dosages used most often for men were 1.2 and 2.4 megaunits. In women the commonest regimen was 2.4 megaunits and again there was a tendency for treatment to be given over several days. Epidemiology treatment was used widely and in one-third of clinics this occurred without confirmation that the patient was a true contact. Consultants used varying diagnoses on the quarterly returns for patients treated epidemiologically in whom the smears and/or cultures were negative. Most clinics classified these cases as 'other conditions requiring treatment' (D2) but as many as 19% of clinics designated these cases as being 'true' gonorrhoea. It is suggested that this results in an overestimate of the number of cases of 'real' gonorrhoea treated in England and Wales.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACRED P., BROWN D. M., HARDY T. L., MANSFORD K. R. A NEW APPROACH TO STUDYING THE PROTEIN-BINDING PROPERTIES OF PENICILLINS. Nature. 1963 Aug 24;199:758–759. doi: 10.1038/199758a0. [DOI] [PubMed] [Google Scholar]
  2. ALERGANT C. D. TREATMENT OF GONORRHOEA WITH PENBRITIN. A REPORT OF 200 CASES. Br J Vener Dis. 1963 Dec;39:225–227. doi: 10.1136/sti.39.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Adler M. W. Diagnostic treatment and reporting criteria for gonorrhoea in sexually transmitted disease clinics in England and Wales. 1: Diagnosis. Br J Vener Dis. 1978 Feb;54(1):10–14. doi: 10.1136/sti.54.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Arya O. P., Pearson C. H., Rao S. K., Blowers R. Treatment of gonorrhoea with trimethoprim-sulphamethoxazole in Uganda. Br J Vener Dis. 1970 Jun;46(3):214–216. doi: 10.1136/sti.46.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown W. J. Epidemiological treatment of venereal disease contacts. Br J Vener Dis. 1973 Apr;49(2):139–140. doi: 10.1136/sti.49.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carroll B. R., Nicol C. S. Trimethoprim-sulphamethoxazole in the treatment of non-gonococcal urethritis and gonorrhoea. Br J Vener Dis. 1970 Feb;46(1):31–33. doi: 10.1136/sti.46.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cobbold R. J., Rees G. D., Parker R. B., Woodcock K. R., John J., Latto D., Redmond A., Willcox R. R. Treatment of gonorrhoea with single oral doses of ampicillin plus probenecid. II. Comparison of results in London and Wales. Br J Vener Dis. 1973 Jun;49(3):268–270. doi: 10.1136/sti.49.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cobbold R. J., Spitzer R. J., Morrison G. D., Willcox R. R. One-session treatment of gonorrhoea in males with procaine penicillin plus probenecid. Postgrad Med J. 1970 Mar;46(533):142–145. doi: 10.1136/pgmj.46.533.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Csonka G. W., Knight G. J. Therapeutic trial of trimethoprim as a potentiator of sulphonamides in gonorrhoea. Br J Vener Dis. 1967 Sep;43(3):161–165. doi: 10.1136/sti.43.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Groth O., Hallqvist L. Oral ampicillin in gonorrhoea. Clinical evaluation. Br J Vener Dis. 1970 Feb;46(1):21–26. doi: 10.1136/sti.46.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gundersen T., Odegaard K., Gjessing H. C. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined. Br J Vener Dis. 1969 Sep;45(3):235–237. doi: 10.1136/sti.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KING A. J. For and against treatment before diagnosis. Br J Vener Dis. 1954 Mar;30(1):13–16. doi: 10.1136/sti.30.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kunin C. M. Clinical pharmacology of the new penicillins. 1. The importance of serum protein binding in determining antimicrobial activity and concentration in serum. Clin Pharmacol Ther. 1966 Mar-Apr;7(2):166–179. doi: 10.1002/cpt196672166. [DOI] [PubMed] [Google Scholar]
  15. Rodin P., Seth A. D. Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid. Br J Vener Dis. 1972 Dec;48(6):517–521. doi: 10.1136/sti.48.6.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WILLCOX R. R. AMPICILLIN ("PENBRITIN") IN THE TREATMENT OF GONORRHOEA. Br J Vener Dis. 1963 Sep;39:164–167. doi: 10.1136/sti.39.3.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WILLCOX R. R. THE NEWER PENICILLINS IN THE TREATMENT OF GONORRHOEA. Postgrad Med J. 1964 Dec;40:SUPPL–SUPPL:209. doi: 10.1136/pgmj.40.suppl.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WILLCOX R. R. Treatment before diagnosis in venereology. Br J Vener Dis. 1954 Mar;30(1):7–12. doi: 10.1136/sti.30.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Willcox R. R. Ampicillin divided doses in the treatment of gonorrhoea. Br J Clin Pract. 1965 Dec;19(12):689–691. [PubMed] [Google Scholar]
  20. Willcox R. R. Treatment of gonorrhoea with two oral doses of antibiotics. Trials of cephalexin and of triple tetracycline (Deteclo). Br J Vener Dis. 1971 Feb;47(1):31–33. doi: 10.1136/sti.47.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Willcox R. R., Woodcock K. R., Latto D., John J., Redmond A., Parker R. B., Rees G. D., Cobbold R. J. Treatment of gonorrhoea with single oral doses of ampicillin plus probenecid. I. Comparison with procaine penicillin. Br J Vener Dis. 1973 Jun;49(3):263–267. doi: 10.1136/sti.49.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Willocx R. R. 'Epidemiological' treatment in venereal diseases other than syphilis. Br J Vener Dis. 1973 Apr;49(2):116–125. doi: 10.1136/sti.49.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]

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