Abstract
Nineteen of 23 serum samples from patients with secondary syphilis, six of 24 from patients with primary syphilis, and four of seven from patients with early latent syphilis had complement-dependent autolymphocytotoxic reactivity at 15 degrees C. After treatment, the reactivity was decreased. It was not directed only against autologous lymphocytes but also against allogeneic lymphocytes. Sephadex G-200 gel filtration showed that the lymphocytotoxins were present in the IgM-containing exclusion peak. Furthermore, serum samples that had high antibody titres in the Reiter protein complement-fixation test or Wassermann-Kolmer reaction also had a high frequency of cold-reacting autolymphocytotoxins. This indicates that the autolymphocytotoxic reactivity is related to the humoral response in syphilis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
- Delhanty J. J., Catterall R. D. Immunoglobulins in syphilis. Lancet. 1969 Nov 22;2(7630):1099–1103. doi: 10.1016/s0140-6736(69)90704-1. [DOI] [PubMed] [Google Scholar]
- Goldberg L. S., Cunningham J. E., Terasaki P. I. Lymphocytotoxins and pernicious anemia. Blood. 1972 Jun;39(6):862–865. [PubMed] [Google Scholar]
- KIRALY K., RACZ I. [Skin tests with purified Treponema pallidum-(TP) vaccine]. Arch Klin Exp Dermatol. 1960;209:583–591. [PubMed] [Google Scholar]
- Kantor F. S. Infection, anergy and cell-mediated immunity. N Engl J Med. 1975 Mar 20;292(12):629–634. doi: 10.1056/NEJM197503202921210. [DOI] [PubMed] [Google Scholar]
- Knapp W., Pateisky K. Lymphocytotoxins in myasthenia gravis. Z Immunitatsforsch Exp Klin Immunol. 1972 Dec;144(4):329–334. [PubMed] [Google Scholar]
- Kreisler M. J., Hirata A. A., Terasaki P. I. Cytotoxins in disease. 3. Antibodies against lymphocytes produced by vaccination. Transplantation. 1970 Nov;10(5):411–415. [PubMed] [Google Scholar]
- Kreisler M., Naito S., Terasaki P. I. Cytotoxins in disease. V. Various diseases. Transplant Proc. 1971 Mar;3(1):112–114. [PubMed] [Google Scholar]
- Levene G. M., Turk J. L., Wright D. J., Grimble A. G. Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis. Lancet. 1969 Aug 2;2(7614):246–247. doi: 10.1016/s0140-6736(69)90010-5. [DOI] [PubMed] [Google Scholar]
- Mayer S., Falkenrodt A., Tongio M. M., Berrebi A. Les lymphocytotoxines froides. Etude critique de la technique. Pathol Biol (Paris) 1973 Nov;21(9):967–972. [PubMed] [Google Scholar]
- Mayer S., Falkenrodt A., Tongio M. M. Cold lymphocytotoxins in infections and parasitic infestations. Tissue Antigens. 1973;3(6):431–438. doi: 10.1111/j.1399-0039.1973.tb00513.x. [DOI] [PubMed] [Google Scholar]
- Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
- Naito S., Mickey M. R., Hirata A., Terasaki P. I. Autolymphocytotoxins following immunization by pregnancy, transplantation, and disease. Tissue Antigens. 1971;1(5):219–228. doi: 10.1111/j.1399-0039.1971.tb00099.x. [DOI] [PubMed] [Google Scholar]
- THIVOLET J., SIMERAY A., ROLLAND M., CHALLUT F. Etude de l'intradermoréaction aux suspensions de Tréponèmes formolées souche Nichols pathogène chez les syphilitiques et les sujets normaux. Ann Inst Pasteur (Paris) 1953 Jul;85(1):23–33. [PubMed] [Google Scholar]
- Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]