Abstract
A comparative study of the new antibacterial agent, rosoxacin, a quinoline derivative, with spectinomycin was made in women with uncomplicated cervical, urethral, pharyngeal, and rectal gonorrhoea. Rosoxacin was given in three oral regimens: 200 mg in a single dose, 300 mg in a single dose, and 300 mg in two doses of 150 mg four hours apart. All culture results 72 hours after administration were negative for Neisseria gonorrhoeae in all 81 women compared with 107 of 109 who received 2 g spectinomycin intramuscularly. Thirty-five of the women successfully treated with rosoxacin harboured penicillinase-producing strains of N gonorrhoeae (PPNG) and 46 non-penicillinase-producing (non-PPNG) strains. Fifty of the women treated with spectinomycin had PPNG strains and 59 non-PPNG strains. Mild self-limiting side effects, principally dizziness, occurred in varying frequency with rosoxacin, but these were difficult to evaluate owing to the characteristics of the patient population and the conditions under which the study was conducted.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashford W. A., Golash R. G., Hemming V. G. Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976 Sep 25;2(7987):657–658. doi: 10.1016/s0140-6736(76)92467-3. [DOI] [PubMed] [Google Scholar]
- Biddle J. W., Swenson J. M., Thornsberry C. Disc agar diffusion antimicrobial susceptibility tests with beta-lactamase producing Neisseria gonorrhoeae. J Antibiot (Tokyo) 1978 Apr;31(4):352–358. doi: 10.7164/antibiotics.31.352. [DOI] [PubMed] [Google Scholar]
- CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Limson B. M., Macasaet R. K. Single oral dose rosoxacin in the treatment of gonorrhoea in males. J Int Med Res. 1982;10(1):42–45. doi: 10.1177/030006058201000109. [DOI] [PubMed] [Google Scholar]
- Maness M. J., Foster G. C., Sparling P. F. Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae. J Bacteriol. 1974 Dec;120(3):1293–1299. doi: 10.1128/jb.120.3.1293-1299.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Kirby S. M., Morris A., Waller R. E., Duncombe R. E. Correlation between hydrolysis of the -lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent. J Bacteriol. 1972 Jun;110(3):988–991. doi: 10.1128/jb.110.3.988-991.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
- Shtibel R. Resistance of cultures of Neisseria gonorrhoeae to spectinomycin. Can Med Assoc J. 1978 Nov 4;119(9):1006–1006. [PMC free article] [PubMed] [Google Scholar]
- Thornsberry C., Jaffee H., Brown S. T., Edwards T., Biddle J. W., Thompson S. E. Spectinomycin-resistant Neisseria gonorrhoeae. JAMA. 1977 May 30;237(22):2405–2406. [PubMed] [Google Scholar]
- Tupasi T. E., Calubiran O. V., Torres C. A. Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1982 Jun;58(3):176–179. doi: 10.1136/sti.58.3.176. [DOI] [PMC free article] [PubMed] [Google Scholar]