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. 1984 Jun;60(3):182–185. doi: 10.1136/sti.60.3.182

Clinical significance of human papillomavirus infection of the uterine cervix in the development of cervical intraepithelial neoplasia.

D Cheetham, J Smith, C Wilson, P E Munday, D V Coleman
PMCID: PMC1046296  PMID: 6329406

Abstract

A group of 25 controls and 30 women with lesions of the cervix associated with papillomavirus were studied prospectively by colposcopy and cytology for up to two years to investigate the relation between human papillomavirus (HPV) infection of the cervix and resolution or progression of cervical intraepithelial neoplasia (CIN). We found that the viral changes were transient and that active infection, as judged by repeated colposcopic and cytological examination, resolved in 83% of the patients. Resolution or persistence of the viral infection did not appear to affect the development of the CIN lesion. The proportion of CIN lesions that resolved and persisted were the same for the study group and the controls. Possible reactivation of latent papillomavirus was noted in three control group patients. Our findings indicate that changes in the cervix associated with papillomavirus should not influence the clinical management or follow up of patients with CIN.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dürst M., Gissmann L., Ikenberg H., zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3812–3815. doi: 10.1073/pnas.80.12.3812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ferenczy A., Braun L., Shah K. V. Human papillomavirus (HPV) in condylomatous lesions of cervix. Am J Surg Pathol. 1981 Oct;5(7):661–670. doi: 10.1097/00000478-198110000-00008. [DOI] [PubMed] [Google Scholar]
  3. Gissmann L., Wolnik L., Ikenberg H., Koldovsky U., Schnürch H. G., zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci U S A. 1983 Jan;80(2):560–563. doi: 10.1073/pnas.80.2.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gissmann L., deVilliers E. M., zur Hausen H. Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer. 1982 Feb 15;29(2):143–146. doi: 10.1002/ijc.2910290205. [DOI] [PubMed] [Google Scholar]
  5. Hills E., Laverty C. R. Electron microscopic detection of papilloma virus particles in selected koilocytotic cells in a routine cervical smear. Acta Cytol. 1979 Jan-Feb;23(1):53–56. [PubMed] [Google Scholar]
  6. Kirkup W., Evans A. S., Brough A. K., Davis J. A., O'Loughlin T., Wilkinson G., Monaghan J. M. Cervical intraepithelial neoplasia and 'wary' atypia: a study of colposcopic, histological and cytological characteristics. Br J Obstet Gynaecol. 1982 Jul;89(7):571–577. doi: 10.1111/j.1471-0528.1982.tb03662.x. [DOI] [PubMed] [Google Scholar]
  7. Kurman R. J., Sanz L. E., Jenson A. B., Perry S., Lancaster W. D. Papillomavirus infection of the cervix I. Correlation of histology with viral structural antigens and DNA sequences. Int J Gynecol Pathol. 1982;1(1):17–28. doi: 10.1097/00004347-198201000-00004. [DOI] [PubMed] [Google Scholar]
  8. Kurman R. J., Shah K. H., Lancaster W. D., Jenson A. B. Immunoperoxidase localization of papillomavirus antigens in cervical dysplasia and vulvar condylomas. Am J Obstet Gynecol. 1981 Aug 15;140(8):931–935. doi: 10.1016/0002-9378(81)90087-9. [DOI] [PubMed] [Google Scholar]
  9. McCance D. J., Walker P. G., Dyson J. L., Coleman D. V., Singer A. Presence of human papillomavirus DNA sequences in cervical intraepithelial neoplasia. Br Med J (Clin Res Ed) 1983 Sep 17;287(6395):784–788. doi: 10.1136/bmj.287.6395.784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Meisels A., Fortin R. Condylomatous lesions of the cervix and vagina. I. Cytologic patterns. Acta Cytol. 1976 Nov-Dec;20(6):505–509. [PubMed] [Google Scholar]
  11. Meisels A., Fortin R., Roy M. Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study. Acta Cytol. 1977 May-Jun;21(3):379–390. [PubMed] [Google Scholar]
  12. Reid R., Stanhope C. R., Herschman B. R., Booth E., Phibbs G. D., Smith J. P. Genital warts and cervical cancer. I. Evidence of an association between subclinical papillomavirus infection and cervical malignancy. Cancer. 1982 Jul 15;50(2):377–387. doi: 10.1002/1097-0142(19820715)50:2<377::aid-cncr2820500236>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  13. Walker P. G., Singer A., Dyson J. L., Shah K. V., To A., Coleman D. V. The prevalence of human papillomavirus antigen in patients with cervical intraepithelial neoplasia. Br J Cancer. 1983 Jul;48(1):99–101. doi: 10.1038/bjc.1983.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Walker P. G., Singer A., Dyson J. L., Shah K. V., Wilters J., Coleman D. V. Colposcopy in the diagnosis of papillomavirus infection of the uterine cervix. Br J Obstet Gynaecol. 1983 Nov;90(11):1082–1086. doi: 10.1111/j.1471-0528.1983.tb06448.x. [DOI] [PubMed] [Google Scholar]

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