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. 1984 Aug;60(4):214–218. doi: 10.1136/sti.60.4.214

Clinical course and treatment of venereal spirochaetosis in New Zealand white rabbits.

R F DiGiacomo, S A Lukehart, C D Talburt, S A Baker-Zander, J Condon, C W Brown
PMCID: PMC1046312  PMID: 6547627

Abstract

Ten sporadic cases of venereal spirochaetosis, caused by Treponema paraluis-cuniculi, were seen in New Zealand white rabbits in two years. An equal number of males and females were affected. Females tended to have milder clinical signs than males. Lesions were usually found on the prepuce in males and the vulva in females, although the anus and skin of the perineum were also affected. Facial lesions were rare. Lesions healed in seven to 28 days in rabbits treated with penicillin. Eight rabbits had antibodies reactive in the Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), and fluorescent treponemal antibody absorbed (FTA-ABS) tests when the disease was first diagnosed. In several rabbits followed longitudinally, RPR test results became negative two to four months after antimicrobial treatment, VDRL antibody titres diminished but usually persisted at low levels, while FTA-ABS antibodies declined slowly and were still evident 12 months after treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLLART P., BOREL L. J., DUREL P. SIGNIFICANCE OF SPIRAL ORGANISMS FOUND, AFTER TREATMENT, IN LATE HUMAN AND EXPERIMENTAL SYPHILIS. Br J Vener Dis. 1964 Jun;40:81–89. doi: 10.1136/sti.40.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cunliffe-Beamer T. L., Fox R. R. Venereal spirochetosis of rabbits: description and diagnosis. Lab Anim Sci. 1981 Aug;31(4):366–371. [PubMed] [Google Scholar]
  3. Cunliffe-Beamer T. L., Fox R. R. Venereal spirochetosis of rabbits: epizootiology. Lab Anim Sci. 1981 Aug;31(4):372–378. [PubMed] [Google Scholar]
  4. Cunliffe-Beamer T. L., Fox R. R. Venereal spirochetosis of rabbits: eradication. Lab Anim Sci. 1981 Aug;31(4):379–381. [PubMed] [Google Scholar]
  5. Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J Immunol. 1981 Oct;127(4):1361–1368. [PubMed] [Google Scholar]
  6. Lukehart S. A., Baker-Zander S. A., Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens. J Immunol. 1980 Jan;124(1):454–460. [PubMed] [Google Scholar]
  7. MILLER J. N., FAZZAN F. P., WHANG S. J. STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. II. TREPONEMA PALLIDUM IMMOBILIZATION (TPI) ANTIBODY AND THE IMMUNE RESPONSE. Br J Vener Dis. 1963 Sep;39:199–203. doi: 10.1136/sti.39.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MILLER J. N. THE APPEARANCE AND PERSISTENCE OF VDRL, RPCF, AND TPI ANTIBODY DURING THE COURSE AND TREATMENT OF EXPERIMENTAL SYPHILIS IN THE RABBIT. J Invest Dermatol. 1964 May;42:367–371. doi: 10.1038/jid.1964.80. [DOI] [PubMed] [Google Scholar]
  9. Ovcinnikov N. M., Delektorskij V. V. Effect of crystalline penicillin and bicillin-1 on experimental syphilis in the rabbit. Electron microscope study. Br J Vener Dis. 1972 Oct;48(5):327–341. doi: 10.1136/sti.48.5.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ovcinnikov N. M., Korbut S. E., Bednova V. N., Timcenko G. F., Milonova T. I. Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit. Br J Vener Dis. 1973 Oct;49(5):413–419. doi: 10.1136/sti.49.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sparling P. F. Diagnosis and treatment of syphilis. N Engl J Med. 1971 Mar 25;284(12):642–653. doi: 10.1056/NEJM197103252841205. [DOI] [PubMed] [Google Scholar]

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