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. 1978 Apr;54(2):77–80. doi: 10.1136/sti.54.2.77

Secnidazole. A 5-nitroimidazole derivative with a long half-life.

D Videau, G Niel, A Siboulet, F Catalan
PMCID: PMC1046365  PMID: 305808

Abstract

The therapeutic activity of a single 2 g dose of secnidazole was studied in patients with urogenital trichomoniasis. In 140 patients, 97% were cured and the drug was well tolerated. In the laboratory, tests on sensitivity were made and the minimal inhibitory concentration (MIC) and the minimal trichomonacidal concentration (MTC) were determined on cultures that had recently been isolated at the clinic, and the pharmacokinetic properties of secnidazole in man were compared with those of tinidazole. The therapeutic efficacy of all the metronidazole derivatives was reviewed and a single-dose treatment is recommended. Therapeutic and prophylactic treatment is achieved by products with a long half-life. Secnidazole, with a half-life of 14.3 +/- 1.3 h (women) and 20.2 +/- 3.1 h (men), is particularly suitable for this type of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COSAR C., DUBOST M., DUBOST P., DEVOIZE P., PALLIERE M. [Determination of metronidazole in the serum and urine in man after oral administration]. Ann Pharm Fr. 1962 Dec;20:872–884. [PubMed] [Google Scholar]
  2. Csonka G. W. Trichomonal vaginitis treated with one dose of metronidazole. Br J Vener Dis. 1971 Dec;47(6):456–458. doi: 10.1136/sti.47.6.456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIAMOND L. S. The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol. 1957 Aug;43(4):488–490. [PubMed] [Google Scholar]
  4. DUREL P., ROIRON V., DELOUCHE L. [Problems posed by the use of streptomycin in the treatment of gonococcal infection]. Bull World Health Organ. 1961;24:343–348. [PMC free article] [PubMed] [Google Scholar]
  5. Korner B., Jensen H. K. Sensitivity of Trichomonas vaginalis to metronidazole, tinidazole, and nifuratel in vitro. Br J Vener Dis. 1976 Dec;52(6):404–408. doi: 10.1136/sti.52.6.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. NICOLI R. M., PLASSE G., LATOURELLE P., QUILICI M. PREMIERS R'ESULTATS STATISTIQUES SUR L''EPID'EMIOLOGIE DE LA TRICHOMONASE URO-G'ENITALE HUMAINE DANS LE SUD-EST DE LA FRANCE. Prophyl Sanit Morale. 1964 Nov;36:256–270. [PubMed] [Google Scholar]
  7. Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
  8. SIBOULET A., DUREL P. A new "one-minute" treatment of gonorrhoea. Br J Vener Dis. 1961 Dec;37:240–243. doi: 10.1136/sti.37.4.240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Swarz H. International experience with a new single 2 gram dose of tinidazole ('Fasigyn'). Curr Med Res Opin. 1974;2(3):181–187. doi: 10.1185/03007997409113636. [DOI] [PubMed] [Google Scholar]
  10. Videau D. Méthode biologique de dosage du métronidazole et du dimétridazole sur germe anaérobie. Pathol Biol (Paris) 1972 Jun-Jul;20(11):625–630. [PubMed] [Google Scholar]
  11. Wallin J., Forsgren A. Tinidazole--a new preparation for T. vaginalis infections. II. Clinical evaluation of treatment with a single oral dose. Br J Vener Dis. 1974 Apr;50(2):148–150. doi: 10.1136/sti.50.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wood B. A., Monro A. M. Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses. Br J Vener Dis. 1975 Feb;51(1):51–53. doi: 10.1136/sti.51.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]

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