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. 1980 Oct;17(5):368–372. doi: 10.1136/jmg.17.5.368

Maternal age and origin of non-disjunction in trisomy 21.

J F Mattei, S Ayme, M G Mattei, F Giraud
PMCID: PMC1048600  PMID: 6452525

Abstract

The role of maternal age in chromosomal non-disjunction was investigated by studying 51 families in whom the origin of the meiotic anomaly had been identified. Results of this study were compared with previously published data. This comparison did not show any difference in mean maternal age, nor in distribution of maternal ages when the origin of non-disjunction was maternal, or paternal, or occurred at the first or second meiotic division. These results make questionable the role of maternal age in the birth of Down's syndrome children.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown W. M., Law P., Smith P. G. Sex chromosome aneuploidy and parental age. Ann Hum Genet. 1969 Jul;33(1):1–14. doi: 10.1111/j.1469-1809.1969.tb01623.x. [DOI] [PubMed] [Google Scholar]
  2. Craig-Holmes A. P., Moore F. B., Shaw M. W. Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over. Am J Hum Genet. 1975 Mar;27(2):178–189. [PMC free article] [PubMed] [Google Scholar]
  3. Creasy M. R., Crolla J. A., Alberman E. D. A cytogenetic study of human spontaneous abortions using banding techniques. Hum Genet. 1976 Feb 29;31(2):177–196. doi: 10.1007/BF00296145. [DOI] [PubMed] [Google Scholar]
  4. Edwards J. H. On the distribution of phenotypes in XXY males and their parents. J Med Genet. 1971 Dec;8(4):434–437. doi: 10.1136/jmg.8.4.434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Erickson J. D. Down syndrome, paternal age, maternal age and birth order. Ann Hum Genet. 1978 Jan;41(3):289–298. doi: 10.1111/j.1469-1809.1978.tb01896.x. [DOI] [PubMed] [Google Scholar]
  6. Evans J. A., Hunter A. G., Hamerton J. L. Down syndrome and recent demographic trends in Manitoba. J Med Genet. 1978 Feb;15(1):43–47. doi: 10.1136/jmg.15.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gardner R. J., Veale A. M., Parslow M. I., Becroft D. M., Shaw R. L., Fitzgerald P. H., Hutchings H. E., McCreanor H. R., Wong J., Eiby J. R. A survey of 972 cytogenetically examined cases of Down's syndrome. N Z Med J. 1973 Nov 14;78(502):403–409. [PubMed] [Google Scholar]
  8. Giraud F., Mattei J. F. Aspects epidémiologiques de la trisomie 21. J Genet Hum. 1975 Oct;23(Suppl):1–30. [PubMed] [Google Scholar]
  9. Hansson A., Mikkelsen M. The origin of the extra chromosome 21 in Down syndrome. Studies of fluorescent variants and satelite association in 26 informative families. Cytogenet Cell Genet. 1978;20(1-6):194–203. doi: 10.1159/000130851. [DOI] [PubMed] [Google Scholar]
  10. Jacobs P. A., Morton N. E. Origin of human trisomics and polyploids. Hum Hered. 1977;27(1):59–72. doi: 10.1159/000152852. [DOI] [PubMed] [Google Scholar]
  11. Jones K. L., Smith D. W. The fetal alcohol syndrome. Teratology. 1975 Aug;12(1):1–10. doi: 10.1002/tera.1420120102. [DOI] [PubMed] [Google Scholar]
  12. Langenbeck U., Hansmann I., Hinney B., Hönig V. On the origin of the supernumerary chromosome in autosomal trisomies--with special reference to Down's syndrome. A bias in tracing nondisjunction by chromosomal and biochemical polymorphisms. Hum Genet. 1976 Jul 27;33(2):89–102. doi: 10.1007/BF00281882. [DOI] [PubMed] [Google Scholar]
  13. Licznerski G., Lindsten J. Trisomy 21 in man due to maternal non-disjunction during the first meiotic division. Hereditas. 1972;70(1):153–154. doi: 10.1111/j.1601-5223.1972.tb01003.x. [DOI] [PubMed] [Google Scholar]
  14. Lindsjö A. Down's syndrome in Sweden. An epidemiological study of a three-year material. Acta Paediatr Scand. 1974 Jul;63(4):571–576. doi: 10.1111/j.1651-2227.1974.tb04849.x. [DOI] [PubMed] [Google Scholar]
  15. Lowry R. B., Jones D. C., Renwick D. H., Trimble B. K. Down syndrome in British Columbia, 1952-73: incidence and mean maternal age. Teratology. 1976 Aug;14(1):29–34. doi: 10.1002/tera.1420140105. [DOI] [PubMed] [Google Scholar]
  16. Magenis R. E., Overton K. M., Chamberlin J., Brady T., Lovrien E. Parental origin of the extra chromosome in Down's syndrome. Hum Genet. 1977 Jun 10;37(1):7–16. doi: 10.1007/BF00293766. [DOI] [PubMed] [Google Scholar]
  17. Mattei J. F., Mattei M. G., Ayme S., Giraud F. Origin of the extra chromosome in trisomy 21. Hum Genet. 1979 Jan 19;46(1):107–110. doi: 10.1007/BF00278908. [DOI] [PubMed] [Google Scholar]
  18. Mikkelsen M., Fischer G., Stene J., Stene E., Petersen E. Incidence study of Down's syndrome in Copenhagen, 1960-1971; with chromosome investigation. Ann Hum Genet. 1976 Nov;40(2):177–182. doi: 10.1111/j.1469-1809.1976.tb00177.x. [DOI] [PubMed] [Google Scholar]
  19. Mikkelsen M., Hallberg A., Poulsen H. Maternal and paternal origin of extra chromosome in trisomy 21. Hum Genet. 1976 Apr 15;32(1):17–21. doi: 10.1007/BF00569972. [DOI] [PubMed] [Google Scholar]
  20. Nakagome Y., Kitagawa T., Iinuma K., Matsunaga E., Shinoda T. Pitfalls in the use of chromosome variants for paternity dispute cases. Hum Genet. 1977 Jul 26;37(3):255–260. doi: 10.1007/BF00393606. [DOI] [PubMed] [Google Scholar]
  21. Robinson J. A., Buckton K. E., Evans H. J. A possible mutation of a fluorescence polymorphism. Ann Hum Genet. 1978 Jan;41(3):323–328. doi: 10.1111/j.1469-1809.1978.tb01899.x. [DOI] [PubMed] [Google Scholar]
  22. Robinson J. A. Origin of extra chromosome in trisomy 21. Lancet. 1973 Jan 20;1(7795):131–133. doi: 10.1016/s0140-6736(73)90198-0. [DOI] [PubMed] [Google Scholar]
  23. Smith G. F., Sachdeva S. Origin of extra chromosome in trisomy 21. Lancet. 1973 Mar 3;1(7801):487–487. doi: 10.1016/s0140-6736(73)91915-6. [DOI] [PubMed] [Google Scholar]
  24. Stene J., Stene E. On data and methods in investigations on parental-age effects. Comments on a paper by J. D. Erickson. Ann Hum Genet. 1978 May;41(4):465–468. doi: 10.1111/j.1469-1809.1978.tb00917.x. [DOI] [PubMed] [Google Scholar]
  25. Stene J., Stene E. Statistical methods for detecting a moderate paternal age effect on incidence of disorder when a maternal one is present. Ann Hum Genet. 1977 Jan;40(3):343–353. doi: 10.1111/j.1469-1809.1977.tb00198.x. [DOI] [PubMed] [Google Scholar]
  26. Wagenbichler P., Killian W., Rett A., Schnedl W. Origin of the extra chromosome no. 21 in Down's syndrome. Hum Genet. 1976 Apr 15;32(1):13–16. doi: 10.1007/BF00569971. [DOI] [PubMed] [Google Scholar]

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