Abstract
Nine children with Duchenne muscular dystrophy were given Sanorex (mazindol), a growth hormone inhibitor, daily for 6 months. There was no significant change in their muscle function, but there was a significant reduction in weight gain and in levels of growth hormone, somatomedin C, hair zinc, serum zinc, and serum LDH. Selenium and glutathione peroxidase in the serum increased significantly. Thirteen other children with growth hormone deficiency had a significant reduction in hair selenium following growth hormone administration. These results show a significant relationship between growth hormone and selenium nutritional status and confirm our previous reports indicating an effect of growth hormone on zinc nutritional status. It is possible that prolonged therapy with a growth hormone inhibitor would attenuate the course and improve the longevity of patients with muscular dystrophy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chen S. Y., Collipp P. J., Boasi L. H., Isenschmid D. S., Verolla R. J., San Roman G. A., Yeh J. K. Fluorometry of selenium in human hair, urine and blood. A single-tube process for submicrogram determination of selenium. Ann Nutr Metab. 1982;26(3):186–190. doi: 10.1159/000176562. [DOI] [PubMed] [Google Scholar]
- Cheruvanky T., Castro-Magana M., Chen S. Y., Collipp P. J., Ghavami-Maibodi Z. Effect of growth hormone on hair, serum, and urine zinc in growth hormone-deficient children. Am J Clin Nutr. 1982 Apr;35(4):668–670. doi: 10.1093/ajcn/35.4.668. [DOI] [PubMed] [Google Scholar]
- Clejan S., Castro-Magana M., Collipp P. J., Jonas E., Maddaiah V. T. Effects of zinc deficiency and castration on fatty acid composition and desaturation in rats. Lipids. 1982 Mar;17(3):129–135. doi: 10.1007/BF02535092. [DOI] [PubMed] [Google Scholar]
- Clejan S., Collipp P. J., Maddaiah V. T. Hormones and liver mitochondria: influence of growth hormone, thyroxine, testosterone, and insulin on thermotropic effects of respiration and fatty acid composition of membranes. Arch Biochem Biophys. 1980 Sep;203(2):744–752. doi: 10.1016/0003-9861(80)90234-9. [DOI] [PubMed] [Google Scholar]
- Clejan S., Maddaiah V. T., Castro-Magana M., Collipp P. J. Zinc deficiency-induced changes in the composition of microsomal membranes and in the enzymatic regulation of glycerolipid synthesis. Lipids. 1981 Jun;16(6):454–460. doi: 10.1007/BF02535014. [DOI] [PubMed] [Google Scholar]
- Collipp P. J., Castro-Magana M., Petrovic M., Thomas J., Cheruvanky T., Chen S. Y., Sussman H. Zinc deficiency: improvement in growth and growth hormone levels with oral zinc therapy. Ann Nutr Metab. 1982;26(5):287–290. doi: 10.1159/000176575. [DOI] [PubMed] [Google Scholar]
- Ewan R. C. Effect of selenium on rat growth, growth hormone and diet utilization. J Nutr. 1976 May;106(5):702–709. doi: 10.1093/jn/106.5.702. [DOI] [PubMed] [Google Scholar]
- Maddaiah V. T., Clejan S., Palekar A. G., Collipp P. J. Hormones and liver mitochondria: effects of growth hormone and thyroxine on respiration, fluorescence of 1-anilino-8-naphthalene sulfonate and enzyme activities of complex I and II of submitochondrial particles. Arch Biochem Biophys. 1981 Sep;210(2):666–677. doi: 10.1016/0003-9861(81)90234-4. [DOI] [PubMed] [Google Scholar]
- Mokri B., Engel A. G. Duchenne dystrophy: electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber. Neurology. 1975 Dec;25(12):1111–1120. doi: 10.1212/wnl.25.12.1111. [DOI] [PubMed] [Google Scholar]
- Sharma R. K., Collipp P. J., Rezvani I., Strimas J., Maddaiah V. T., Rezvani E. Clinical evaluation of the anorexic activity and safety of 42-548 in children. Report of a clinical trial. Clin Pediatr (Phila) 1973 Mar;12(3):145–149. doi: 10.1177/000992287301200308. [DOI] [PubMed] [Google Scholar]
- Zatz M., Betti R. T., Levy J. A. Benign Duchenne muscular dystrophy in a patient with growth hormone deficiency. Am J Med Genet. 1981;10(3):301–304. doi: 10.1002/ajmg.1320100313. [DOI] [PubMed] [Google Scholar]