Abstract
A family study of hidradenitis suppurativa was undertaken based on 26 subjects with the disease. The probands were obtained from Hospital Activity Analysis (HAA) records for a three year period (1980 to 1983) and by direct referral from hospital specialists over a six month period (1983 to 1984). Family pedigree information was collected by home visits or hospital interviews and confirmation of the disease in relatives was obtained by examination where possible or by telephone contact and hospital/GP records. A total of 62 affected persons was eventually ascertained, 40 females and 22 males. In 11 families there was evidence in favour of a genetic aetiology with single gene transmission. In another three families there was historical evidence of familial occurrence and in nine families no family history was obtained at the time of enquiry. Problems of ascertainment, including variability of age of onset and psychosocial factors, were noted and could be responsible for false negative family histories or underestimation of affected persons.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRUNSTING H. A. Hidradenitis and other variants of acne. AMA Arch Derm Syphilol. 1952 Mar;65(3):303–315. doi: 10.1001/archderm.1952.01530220044004. [DOI] [PubMed] [Google Scholar]
- Bergeron J. R., Stone O. J. Interstitial keratitis associated with hidradenitis suppurativa. Arch Dermatol. 1967 May;95(5):473–475. [PubMed] [Google Scholar]
- Ching C. C., Stahlgren L. H. Clinical review of hidradenitis suppurativa: management of cases with severe perianal involvement. Dis Colon Rectum. 1965 Sep-Oct;8(5):349–352. doi: 10.1007/BF02627258. [DOI] [PubMed] [Google Scholar]
- Dvorak V. C., Root R. K., MacGregor R. R. Host-defense mechanisms in hidradenitis suppurativa. Arch Dermatol. 1977 Apr;113(4):450–453. [PubMed] [Google Scholar]
- Fitzsimmons J. S., Fitzsimmons E. M., Gilbert G. Familial hidradenitis suppurativa: evidence in favour of single gene transmission. J Med Genet. 1984 Aug;21(4):281–285. doi: 10.1136/jmg.21.4.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gordon S. W. Hidradenitis suppurativa: a closer look. J Natl Med Assoc. 1978 May;70(5):339–343. [PMC free article] [PubMed] [Google Scholar]
- Humphrey L. J., Playforth H., Leavell U. W., Jr Squamous cell carcinoma arising in hidradenitis suppurativum. Arch Dermatol. 1969 Jul;100(1):59–62. [PubMed] [Google Scholar]
- Knaysi G. A., Jr, Cosman B., Crikelair G. F. Hidradenitis suppurativa. JAMA. 1968 Jan 1;203(1):19–22. [PubMed] [Google Scholar]
- Rosner I. A., Richter D. E., Huettner T. L., Kuffner G. H., Wisnieski J. J., Burg C. G. Spondyloarthropathy associated with hidradenitis suppurative and acne conglobata. Ann Intern Med. 1982 Oct;97(4):520–525. doi: 10.7326/0003-4819-97-4-520. [DOI] [PubMed] [Google Scholar]
- Self S. J., Montes L. F. Follicular occlusion triad. South Med J. 1970 Feb;63(2):156–160. doi: 10.1097/00007611-197002000-00006. [DOI] [PubMed] [Google Scholar]