Skip to main content
PMC home page
Journal of Epidemiology and Community Health logoLink to Journal of Epidemiology and Community Health
. 1979 Dec;33(4):236–242. doi: 10.1136/jech.33.4.236

Polymorphisms and multiple sclerosis in Orkney.

D F Roberts, S S Papiha, D C Poskanzer
PMCID: PMC1051963  PMID: 119821

Abstract

Study of the blood group, isoenzyme, and serum protein systems representing polymorphic variants at 23 loci, in a population of 53 multiple sclerosis patients in Orkney, their relatives, and control series, showed that patients were neither morre homozygous nor more inbred than controls. Any possible association of the disorder with the ABO and rhesus blood groups was not directly causal, but was related to the families of the patients rather than to the patients themselves.

Full text

PDF
239

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN E. S. DISTRIBUTION OF THE ABO AND RHESUS (D) BLOOD GROUPS IN THE NORTH OF SCOTLAND. Heredity (Edinb) 1965 May;20:289–303. doi: 10.1038/hdy.1965.35. [DOI] [PubMed] [Google Scholar]
  2. Bertrams J., Kuwert E., Liedtke U. HL-A antigens and multiple sclerosis. Tissue Antigens. 1972;2(5):405–408. doi: 10.1111/j.1399-0039.1972.tb00060.x. [DOI] [PubMed] [Google Scholar]
  3. CLARKE C. A., EDWARDS J. W., HADDOCK D. R., HOWEL-EVANS A. W., MCCONNELL R. B., SHEPPARD P. M. ABO blood groups and secretor character in duodenal ulcer; population and sibship studies. Br Med J. 1956 Sep 29;2(4995):725–731. doi: 10.1136/bmj.2.4995.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Compston D. A., Batchelor J. R., McDonald W. I. B-lymphocyte alloantigens associated with multiple sclerosis. Lancet. 1976 Dec 11;2(7998):1261–1265. doi: 10.1016/s0140-6736(76)92027-4. [DOI] [PubMed] [Google Scholar]
  5. FILDES R. A., PARR C. W. HUMAN RED-CELL PHOSPHOGLUCONATE DEHYDROGENASES. Nature. 1963 Nov 30;200:890–891. doi: 10.1038/200890a0. [DOI] [PubMed] [Google Scholar]
  6. Fildes R. A., Harris H. Genetically determined variation of adenylate kinase in man. Nature. 1966 Jan 15;209(5020):261–263. doi: 10.1038/209261a0. [DOI] [PubMed] [Google Scholar]
  7. HOPKINSON D. A., SPENCER N., HARRIS H. RED CELL ACID PHOSPHATASE VARIANTS: A NEW HUMAN POLYMORPHISM. Nature. 1963 Sep 7;199:969–971. doi: 10.1038/199969a0. [DOI] [PubMed] [Google Scholar]
  8. Naito S., Namerow N., Mickey M. R., Terasaki P. I. Multiple sclerosis: association with HL-A3. Tissue Antigens. 1972;2(1):1–4. doi: 10.1111/j.1399-0039.1972.tb00111.x. [DOI] [PubMed] [Google Scholar]
  9. Opelz G., Terasaki P., Myers L., Ellison G., Ebers G., Zabriskie J., Weiner H., Kempe H., Sibley W. The association of HLA antigens A3, B7, and DW2 with 330 multiple sclerosis patients in the United States. Tissue Antigens. 1977 Jan;9(1):54–58. doi: 10.1111/j.1399-0039.1977.tb01080.x. [DOI] [PubMed] [Google Scholar]
  10. POULIK M. D. Starch gel electrophoresis in a discontinous system of buffers. Nature. 1957 Dec 28;180(4600):1477–1479. doi: 10.1038/1801477a0. [DOI] [PubMed] [Google Scholar]
  11. Roberts D. F., Roberts M. J., Poskanzer D. C. Genetic analysis of multiple sclerosis in Orkney. J Epidemiol Community Health. 1979 Dec;33(4):229–235. doi: 10.1136/jech.33.4.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SPENCER N., HOPKINSON D. A., HARRIS H. PHOSPHOGLUCOMUTASE POLYMORPHISM IN MAN. Nature. 1964 Nov 21;204:742–745. doi: 10.1038/204742a0. [DOI] [PubMed] [Google Scholar]
  13. Whitaker J. N., Herrmann K. L., Rogentine G. N., Stein S. F., Kollins L. L. Immunogenetic analysis and serum viral antibody titers in multiple sclerosis. Arch Neurol. 1976 Jun;33(6):399–403. doi: 10.1001/archneur.1976.00500060005002. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Epidemiology and Community Health are provided here courtesy of BMJ Publishing Group

RESOURCES