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. 1962 Nov;10(6):515–523. doi: 10.1128/am.10.6.515-523.1962

Biosynthesis of Cephalosporin C

I. Factors Affecting the Fermentation

J L Ott 1, C W Godzeski 1, D Pavey 1, J D Farran 1, D R Horton 1
PMCID: PMC1057906  PMID: 16349624

Abstract

A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I. 49,137). dl-Methionine increased the yield of both antibiotics, with more effect on cephalosporin N. l-Cystine had a greater enhancing effect on formation of cephalosporin C than on formation of cephalosporin N in synthetic media; serine increased yields of cephalosporin C under certain conditions. Disaccharides or polysaccharides appeared to be the best source for carbohydrates. No evidence was found for precursor action such as is found in penicillin fermentations. The ability of resting cells to produce antibiotic was demonstrated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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