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. 1965 Mar;13(2):190–193. doi: 10.1128/am.13.2.190-193.1965

Effects of Minerals on Neomycin Production by Streptomyces fradiae

M K Majumdar 1, S K Majumdar 1
PMCID: PMC1058219  PMID: 14325877

Abstract

A study was made on the mineral requirements of Streptomyces fradiae strain 3535 for neomycin production. It was observed that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production were 10.8, 1.0, and 0.115 μg, respectively. K2HPO4 was required at a concentration of 0.1% for maximal yield of neomycin, whereas NaCl and the metals Mn and Cu were without any effect. High doses of Zn (0.23 μg/ml or above) caused destruction of neomycin after the fifth day of fermentation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKER R. F., LECHEVALIER H. Some nutritional requirements of Streptomyces griseus 3570 for growth and candicidin production. Appl Microbiol. 1954 May;2(3):152–157. doi: 10.1128/am.2.3.152-157.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIRK Y., SILVER W. S., HEIM A. H. A b-type cytochrome form Streptomyces fradiae. Biochim Biophys Acta. 1957 Jul;25(1):227–228. doi: 10.1016/0006-3002(57)90461-4. [DOI] [PubMed] [Google Scholar]
  3. CHESTERS C. G. C., ROLINSON G. N. Trace elements and streptomycin production. J Gen Microbiol. 1951 Aug;5(3):559–565. doi: 10.1099/00221287-5-3-559. [DOI] [PubMed] [Google Scholar]
  4. HEIM A. H., SILVER W. S., BIRK Y. Cytochrome composition of some strains of Streptomyces. Nature. 1957 Sep 21;180(4586):608–609. doi: 10.1038/180608a0. [DOI] [PubMed] [Google Scholar]
  5. KATZ E., PIENTA P., SIVAK A. The role of nutrition in the synthesis of actinomycin. Appl Microbiol. 1958 Jul;6(4):236–241. doi: 10.1128/am.6.4.236-241.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MAJUMDAR S. K., BOSE S. K. Trace element requirements of Bacillus subtilis for mycobacillin formation. J Bacteriol. 1960 Apr;79:564–565. doi: 10.1128/jb.79.4.564-565.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. RATLEDGE C., WINDER F. G. The accumulation of salicylic acid by mycobacteria during growth on an iron-deficient medium. Biochem J. 1962 Sep;84:501–506. doi: 10.1042/bj0840501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Reynolds D. M., Waksman S. A. Grisein, an Antibiotic Produced by Certain Strains of Streptomyces griseus. J Bacteriol. 1948 May;55(5):739–752. doi: 10.1128/jb.55.5.739-752.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. WEBLEY D. M. The effect of deficiency of iron, zinc and manganese on the growth and morphology of Nocardia opaca. J Gen Microbiol. 1960 Aug;23:87–92. doi: 10.1099/00221287-23-1-87. [DOI] [PubMed] [Google Scholar]
  10. WINDER F. G., O'HARA C. Effects of iron deficiency and of zinc deficiency on the composition of Mycobacterium smegmatis. Biochem J. 1962 Jan;82:98–108. doi: 10.1042/bj0820098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Waksman S. A., Lechevalier H. A., Harris D. A. NEOMYCIN-PRODUCTION AND ANTIBIOTIC PROPERTIES. J Clin Invest. 1949 Sep;28(5 Pt 1):934–939. doi: 10.1172/JCI102182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Waksman S. A., Lechevalier H. A. Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms. Science. 1949 Mar 25;109(2830):305–307. doi: 10.1126/science.109.2830.305. [DOI] [PubMed] [Google Scholar]
  13. Woodruff H. B., Ruger M. Studies on the Physiology of a Streptomycin-producing Strain of Streptomyces griseus on Proline Medium. J Bacteriol. 1948 Sep;56(3):315–321. [PMC free article] [PubMed] [Google Scholar]

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