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. 1994 Jan;70(1):F16–F18. doi: 10.1136/fn.70.1.f16

Static respiratory compliance in the newborn. II: Its potential for improving the selection of infants for early surfactant treatment.

R A Wilkie 1, M H Bryan 1, W O Tarnow-Mordi 1
PMCID: PMC1060981  PMID: 8117121

Abstract

Static respiratory system compliance (Crs) and lecithin/sphingomyelin (L/S) ratios in tracheal aspirates were estimated in two independent groups of mechanically ventilated infants. Crs was measured rapidly at the cotside using a passive expiratory flow technique and L/S ratios were estimated in the laboratory by high performance liquid chromatography. In the reference group of 22 infants, Crs < 1.8 ml/cm H2O/m predicted surfactant deficiency with a positive predictive value of 100% and a negative predictive value of 92%. In the validation group of 23 infants, Crs < 1.8 ml/cm H2O/m predicted surfactant deficiency with a positive predictive value of 94% and a negative predictive value of 83%. Measurement of static Crs is a rapid, non-invasive technique which may usefully supplement current methods of selecting infants at high risk of respiratory distress syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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