Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1958 Aug;37(8):1131–1143. doi: 10.1172/JCI103703

Salicylates and Thyroid Function. I. Depression of Thyroid Function

Frank K Austen 1,2, Milton E Rubini 1,2, William H Meroney 1,2, J Wolff 1,2
PMCID: PMC1062780  PMID: 13563643

Full text

PDF
1143

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER W. D., JOHNSON K. W. A comparison of the effects of acetylsalicyclic acid and DL-triiodothyronine in patients with myxoedema. Clin Sci. 1956 Nov;15(4):593–601. [PubMed] [Google Scholar]
  2. ALEXANDER W. D., JOHNSON K. W. Comparison of the metabolic stimulating action of aspirin and thyroid. Nature. 1956 Aug 4;178(4527):259–260. doi: 10.1038/178259a0. [DOI] [PubMed] [Google Scholar]
  3. BARKER S. B., HUMPHREY M. J., SOLEY M. H. The clinical determination of protein-bound iodine. J Clin Invest. 1951 Jan;30(1):55–62. doi: 10.1172/JCI102416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BERSON S. A., YALOW R. S., SORRENTINO J., ROSWIT B. The determination of thyroidal and renal plasma I131 clearance rates as a routine diagnostic test of thyroid dysfunction. J Clin Invest. 1952 Feb;31(2):141–158. doi: 10.1172/JCI102585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BRICKER N. S., HLAD C. J., Jr Observations on the mechanism of the renal clearance of I131. J Clin Invest. 1955 Jul;34(7 Pt 1):1057–1072. doi: 10.1172/JCI103155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BRODY T. M. Action of sodium salicylate and related compounds on tissue metabolism in vitro. J Pharmacol Exp Ther. 1956 May;117(1):39–51. [PubMed] [Google Scholar]
  7. CASTOR C. W., BEIERWALTES W. Effect of 2, 4-dinitrophenol on thyroid function in man. J Clin Endocrinol Metab. 1956 Aug;16(8):1026–1031. doi: 10.1210/jcem-16-8-1026. [DOI] [PubMed] [Google Scholar]
  8. COCHRAN J. B. Further observations on the metabolic stimulating effect of salicylate. Br Med J. 1954 Mar 27;1(4864):733–734. doi: 10.1136/bmj.1.4864.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. COCHRAN J. B. The respiratory effects of salicylate. Br Med J. 1952 Nov 1;2(4791):964–967. doi: 10.1136/bmj.2.4791.964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cutting W. C., Rytand D. A., Tainter M. L. RELATIONSHIP BETWEEN BLOOD CHOLESTEROL AND INCREASED METABOLISM FROM DINITROPHENOL AND THYROID. J Clin Invest. 1934 Jul;13(4):547–552. doi: 10.1172/JCI100604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GOLDBERG R. C., GREEP R. O., WOLFF J. Studies on the nature of the thyroid-pituitary interrelationship. Endocrinology. 1957 Jan;60(1):38–52. doi: 10.1210/endo-60-1-38. [DOI] [PubMed] [Google Scholar]
  12. GOLDBERG R. C., WOLFF J., GREEP R. O. The mechanism of depression of plasma protein bound iodine by 2,4 dinitrophenol. Endocrinology. 1955 May;56(5):560–566. doi: 10.1210/endo-56-5-560. [DOI] [PubMed] [Google Scholar]
  13. INGBAR S. H., FREINKEL N. Simultaneous estimation of rates of thyroxine degradation and thyroid hormone synthesis. J Clin Invest. 1955 Jun;34(6):808–819. doi: 10.1172/JCI103136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Keating F. R., Wang J. C., Luellen T. J., Williams M. M., Power M. H., McConahey W. M. THE MEASUREMENT OF THE IODINE-ACCUMULATING FUNCTION OF THE HUMAN THYROID GLAND. J Clin Invest. 1949 Mar;28(2):217–227. doi: 10.1172/JCI102063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. LARDY H. A., WELLMAN H. Oxidative phosphorylations; rôle of inorganic phosphate and acceptor systems in control of metabolic rates. J Biol Chem. 1952 Mar;195(1):215–224. [PubMed] [Google Scholar]
  16. MEADE B. W. Effect of certain hydroxybenzoic acids on the oxygen consumption of Wistar rats. Ann Rheum Dis. 1954 Mar;13(1):60–62. doi: 10.1136/ard.13.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MECKSTROTH C. V., RAPPORT R. L., CURTIS G. M., SIMCOX S. J. The laboratory diagnosis of extrathyroidal hypermetabolism. J Clin Endocrinol Metab. 1952 Oct;12(10):1373–1379. doi: 10.1210/jcem-12-10-1373. [DOI] [PubMed] [Google Scholar]
  18. PACKER L. Coupled phosphorylation in rat heart muscle sarcosomes. Arch Biochem Biophys. 1957 Jul;70(1):290–293. doi: 10.1016/0003-9861(57)90105-4. [DOI] [PubMed] [Google Scholar]
  19. REID J. A new outlook on the action of salicylate. Scott Med J. 1957 Mar;2(3):91–96. doi: 10.1177/003693305700200303. [DOI] [PubMed] [Google Scholar]
  20. ROBBINS J., RALL J. E. The interaction of thyroid hormones and protein in biological fluids. Recent Prog Horm Res. 1957;13:161–208. [PubMed] [Google Scholar]
  21. ROBBINS J. Reverse-flow zone electrophoresis; a method for determining the thyroxine-binding capacity of serum protein. Arch Biochem Biophys. 1956 Aug;63(2):461–469. doi: 10.1016/0003-9861(56)90062-5. [DOI] [PubMed] [Google Scholar]
  22. SEEBERG V. P., HANSEN D., WHITNEY B. Absorption and distribution of salicylamide. J Pharmacol Exp Ther. 1951 Mar;101(3):275–282. [PubMed] [Google Scholar]
  23. SMITH M. J. H., MEADE B. W. The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat. Biochem J. 1952 Apr;51(1):18–20. doi: 10.1042/bj0510018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SMITH M. J., JEFFREY S. W. The effects of salicylate on oxygen consumption and carbohydrate metabolism in the isolated rat diaphragm. Biochem J. 1956 Jul;63(3):524–528. doi: 10.1042/bj0630524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. SPROULL D. H. A peripheral action of sodium salicylate. Br J Pharmacol Chemother. 1954 Sep;9(3):262–264. doi: 10.1111/j.1476-5381.1954.tb01678.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. STERLING K., CHODOS R. B. Radiothyroxine turnover studies in myxedema, thyrotoxicosis, and hypermetabolism without endocrine disease. J Clin Invest. 1956 Jul;35(7):806–813. doi: 10.1172/JCI103333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. STERLING K., LASHOF J. C., MAN E. B. Disappearance from serum of I131-labeled l-thyroxine and l-triiodothyronine in euthyroid subjects. J Clin Invest. 1954 Jul;33(7):1031–1035. doi: 10.1172/JCI102970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. TENNEY S. M., MILLER R. M. The respiratory and circulatory actions of salicylate. Am J Med. 1955 Oct;19(4):498–508. doi: 10.1016/0002-9343(55)90342-9. [DOI] [PubMed] [Google Scholar]
  29. WOLFF J., AUSTEN F. K. Salicylates and thyroid function. II. The effect on the thyroid-pituitary interrelation. J Clin Invest. 1958 Aug;37(8):1144–1152. doi: 10.1172/JCI103704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. WOLFF J., RUBIN L., CHAIKOFF I. L. The influence of 2,4-dinitrophenol on plasma protein bound iodine. J Pharmacol Exp Ther. 1950 Jan;98(1):45–48. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES