Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1954 Oct;33(10):1303–1313. doi: 10.1172/JCI103006

The Enzymatic Dissolution Of Experimental Arterial Thrombi in the Dog by Trypsin, Chymotrypsin and Plasminogen Activators1,2

Sol Sherry a, Antoinette Titchener a, Leonard Gottesman a, Philip Wasserman a, Walter Troll a
PMCID: PMC1072549  PMID: 13201635

Full text

PDF
1305

Images in this article

1307Image
on p.1307

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTRUP T. The activation of a proteolytic enzyme in blood by animal tissue. Biochem J. 1951 Nov;50(1):5–11. doi: 10.1042/bj0500005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHRISTENSEN L. R., SMITH D. H., Jr Plasminogen purification by acid extraction. Proc Soc Exp Biol Med. 1950 Aug;74(4):840–844. doi: 10.3181/00379727-74-18063. [DOI] [PubMed] [Google Scholar]
  3. CLIFFTON E. E., CANNAMELA D. Fibrinolytic and proteolytic activity of a human plasminogen, prepared from fraction III of human plasma. J Appl Physiol. 1953 Jul;6(1):42–50. doi: 10.1152/jappl.1953.6.1.42. [DOI] [PubMed] [Google Scholar]
  4. CLIFFTON E. E., GROSSI C. E., CANNAMELA D. Lysis of thrombi produced by sodium morrhuate in the femoral vein of dogs by human plasmin (fibrinolysin). Ann Surg. 1954 Jan;139(1):52–62. doi: 10.1097/00000658-195401000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Christensen L. R. METHODS FOR MEASURING THE ACTIVITY OF COMPONENTS OF THE STREPTOCOCCAL FIBRINOLYTIC SYSTEM, AND STREPTOCOCCAL DESOXYRIBONUCLEASE. J Clin Invest. 1949 Jan;28(1):163–172. doi: 10.1172/JCI102045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FANTL P., FITZPATRICK M. Fibrinolysis induced by brain extracts. Br J Exp Pathol. 1950 Apr;31(2):131–137. [PMC free article] [PubMed] [Google Scholar]
  7. INNERFIELD I., ANGRIST A., SCHWARZ A. Parenteral administration of trypsin; clinical effect in 538 patients. J Am Med Assoc. 1953 Jun 13;152(7):597–605. doi: 10.1001/jama.1953.03690070031009. [DOI] [PubMed] [Google Scholar]
  8. INNERFIELD I., SCHWARZ A., ANGRIST A. Intravenous trypsin; its anticoagulant, fibrinolytic and thrombolytic effects. J Clin Invest. 1952 Dec;31(12):1049–1055. doi: 10.1172/JCI102698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. JENSEN H., CHAMOVITZ D. L., VOLKRINGER E., GRAY E., GOSNEY J. E., KOCHOLATY W. Antifibrinolytic activity in plasma after exposure to cold and after chymotrypsin administration. Blood. 1953 Apr;8(4):324–328. [PubMed] [Google Scholar]
  10. JOHNSON A. J., TILLETT W. S. The lysis in rabbits of intravascular blood clots by the streptococcal fibrinolytic system (streptokinase). J Exp Med. 1952 May 1;95(5):449–464. doi: 10.1084/jem.95.5.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KOCHOLATY W., ELLIS W. W., JENSEN H. Activation of plasminogen by trypsin and plasmin. Blood. 1952 Sep;7(9):882–890. [PubMed] [Google Scholar]
  12. MULLERTZ S. A plasminogen activator in spontaneously active human blood. Proc Soc Exp Biol Med. 1953 Feb;82(2):291–295. doi: 10.3181/00379727-82-20097. [DOI] [PubMed] [Google Scholar]
  13. McCANN S. F., LASKOWSKI M. Determination of trypsin inhibitor in blood plasma. J Biol Chem. 1953 Sep;204(1):147–152. [PubMed] [Google Scholar]
  14. PEANASKY R. J., LASKOWSKI M. Partial purification of the trypsin inhibitor from blood plasma. J Biol Chem. 1953 Sep;204(1):153–157. [PubMed] [Google Scholar]
  15. PILLEMER L., RATNOFF O. D., BLUM L., LEPOW I. H. The inactivation of complement and its components by plasmin. J Exp Med. 1953 Apr;97(4):573–589. doi: 10.1084/jem.97.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  17. RATNOFF O. D. Studies on a proteolytic enzyme in human plasma. IX. Fibrinogen and fibrin as substrates for the proteolytic enzyme of plasma. J Clin Invest. 1953 Jun;32(6):473–479. doi: 10.1172/JCI102762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. REMMERT L. F., COHEN P. P. Partial purification and properties of a proteolytic enzyme of human serum. J Biol Chem. 1949 Nov;181(1):431–448. [PubMed] [Google Scholar]
  19. SHERRY S. The fibrinolytic activity of streptokinase activated human plasmin. J Clin Invest. 1954 Jul;33(7):1054–1063. doi: 10.1172/JCI102973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. SHULMAN N. R. Studies on the inhibition of proteolytic enzymes by serum. I. The mechanism of the inhibition of trypsin, plasmin, and chymotrypsin by serum using fibrin tagged with I131 as a substrate. J Exp Med. 1952 Jun;95(6):571–591. doi: 10.1084/jem.95.6.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TROLL W., SHERRY S., WACHMAN J. The action of plasmin on synthetic substrates. J Biol Chem. 1954 May;208(1):85–93. [PubMed] [Google Scholar]
  22. Tagnon H. J., Palade G. E. ACTIVATION OF PROPLASMIN BY A FACTOR FROM MAMMALIAN TISSUE. J Clin Invest. 1950 Mar;29(3):317–324. doi: 10.1172/JCI102260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tillett W. S., Sherry S. THE EFFECT IN PATIENTS OF STREPTOCOCCAL FIBRINOLYSIN (STREPTOKINASE) AND STREPTOCOCCAL DESOXYRIBONUCLEASE ON FIBRINOUS, PURULENT, AND SANGUINOUS PLEURAL EXUDATIONS. J Clin Invest. 1949 Jan;28(1):173–190. doi: 10.1172/JCI102046. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES