Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1957 Nov;36(11):1600–1607. doi: 10.1172/JCI103559

Quantitative Studies on Human Urinary Metabolites of Tryptophan as Affected by Isoniazid and Deoxypyridoxine1

J M Price a,2, R R Brown a, Frank C Larson a
PMCID: PMC1072766  PMID: 13475500

Full text

PDF
1602

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIEHL J. P., SKLAVEM J. H. Toxicity of isoniazid. Am Rev Tuberc. 1953 Aug;68(2):296–297. [PubMed] [Google Scholar]
  2. BIEHL J. P., VILTER R. W. Effect of isoniazid on vitamin B6 metabolism; its possible significance in producing isoniazid neuritis. Proc Soc Exp Biol Med. 1954 Mar;85(3):389–392. doi: 10.3181/00379727-85-20891. [DOI] [PubMed] [Google Scholar]
  3. BOKMAN A. H., SCHWEIGERT B. S. 3-Hydroxyanthranilic acid metabolism. III. Molar conversion to quinolinic acid. J Biol Chem. 1950 Sep;186(1):153–158. [PubMed] [Google Scholar]
  4. BOONE I. U., TURNEY D. F., LANGHAM W. H. Isoniazid in vitamin B6-deficient rats. J Lab Clin Med. 1955 Oct;46(4):549–559. [PubMed] [Google Scholar]
  5. BRAY H. G., THORPE W. V., WOOD P. B. The fate of certain organic acids and amides in the rabbit. 12. Aminohydroxybenzoic acids. Biochem J. 1951 Apr;48(4):394–399. doi: 10.1042/bj0480394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BROWN R. R., ELLIS M. E., PRICE J. M. Quantitative studies on the urinary excretion of tryptophan metabolites by humans ingesting a constant diet. J Nutr. 1956 Nov 10;60(3):323–333. doi: 10.1093/jn/60.3.323. [DOI] [PubMed] [Google Scholar]
  7. BROWN R. R., PRICE J. M. Quantitative studies on metabolites of tryptophan in the urine of the dog, cat, rat, and man. J Biol Chem. 1956 Apr;219(2):985–997. [PubMed] [Google Scholar]
  8. BROWN R. R. The isolation and determination of urinary hydroxykynurenine. J Biol Chem. 1957 Aug;227(2):649–652. [PubMed] [Google Scholar]
  9. CHARCONNET-HARDING F., DALGLIESH C. E., NEUBERGER A. The relation between riboflavin and tryptophan metabolism, studied in the rat. Biochem J. 1953 Mar;53(4):513–521. doi: 10.1042/bj0530513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DALGLIESH C. E., TABECHIAN H. Comparison of the metabolism of uniformly 14C-labelled L-phenylalanine, L-tyrosine and L-tryptophan in the rat. Biochem J. 1956 Apr;62(4):625–633. doi: 10.1042/bj0620625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. DALGLIESH C. E., TEKMAN S. The excretion of kynurenine and 3-hydroxykynurenine by man. Biochem J. 1954 Mar;56(3):458–463. [PMC free article] [PubMed] [Google Scholar]
  12. DALGLIESH C. E., TEKMAN S. The excretion of kynurenine and 3-hydroxykynurenine by man. Biochem J. 1954 Mar;56(3):458–463. [PMC free article] [PubMed] [Google Scholar]
  13. DALGLIESH C. E. The relation between pyridoxin and tryptophan metabolism, studied in the rat. Biochem J. 1952 Sep;52(1):3–14. doi: 10.1042/bj0520003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. GLAZER H. S., MUELLER J. F., THOMPSON C., HAWKINS V. R., VILTER R. W. A study of urinary excretion of xanthurenic acid and other tryptophan metabolites in human beings with pyridoxine deficiency induced by desoxypyridoxine. Arch Biochem Biophys. 1951 Sep;33(2):243–251. doi: 10.1016/0003-9861(51)90102-6. [DOI] [PubMed] [Google Scholar]
  15. HENDERSON L. M. Quinolinic acid metabolism; replacement of nicotinic acid for the growth of the rat and Neurospora. J Biol Chem. 1949 Dec;181(2):677–685. [PubMed] [Google Scholar]
  16. HENDERSON L. M., WEINSTOCK I. M., RAMASARMA G. B. Effect of deficiency of B vitamins on the metabolism of tryptophan by the rat. J Biol Chem. 1951 Mar;189(1):19–29. [PubMed] [Google Scholar]
  17. JONES W. A., JONES G. P. Peripheral neuropathy due to isoniazid; report of two cases. Lancet. 1953 May 30;1(6770):1073–1074. doi: 10.1016/s0140-6736(53)92204-1. [DOI] [PubMed] [Google Scholar]
  18. KAIHARA M., PRICE J. M., TAKAHASHI H. The conversion of kynurenic acid to quinaldic acid by humans and rats. J Biol Chem. 1956 Dec;223(2):705–708. [PubMed] [Google Scholar]
  19. KNOX W. E. Two mechanisms which increase in vivo the liver tryptophan peroxidase activity: specific enzyme adaptation and stimulation of the pituitary adrenal system. Br J Exp Pathol. 1951 Oct;32(5):462–469. [PMC free article] [PubMed] [Google Scholar]
  20. LUBING H. N. Peripheral neuropathy in tuberculosis patients treated with isoniazid. Am Rev Tuberc. 1953 Sep;68(3):458–461. doi: 10.1164/art.1953.68.3.458. [DOI] [PubMed] [Google Scholar]
  21. MAKINO K., SATOH K., FUJIKI T., KAWAGUCHI K. Relation of 3-hydroxy-kynurenine to the Ehrlich diazo reaction of urine in severe tuberculosis. Nature. 1952 Dec 6;170(4336):977–978. doi: 10.1038/170977a0. [DOI] [PubMed] [Google Scholar]
  22. MAQSOOD M., BIOL M. I. Biological effects of ionizing radiation. Pak J Health. 1957 Jan;6(4):227–232. [PubMed] [Google Scholar]
  23. MUSAJO L., SPADA A., COPPINI D. Isolation of 3-hydroxyanthranilic acid from pathological human urine after administration of L-tryptophan. J Biol Chem. 1952 May;196(1):185–188. [PubMed] [Google Scholar]
  24. PRICE J. M. The determination of N-methyl-2-pyridone-5-carboxamide in human urine. J Biol Chem. 1954 Nov;211(1):117–124. [PubMed] [Google Scholar]
  25. ROSEN F. Effect of isonicotinic acid hydrazide on niacin and pyridoxine metabolism in rats. Proc Soc Exp Biol Med. 1955 Feb;88(2):243–246. doi: 10.3181/00379727-88-21552. [DOI] [PubMed] [Google Scholar]
  26. WALTERS C. J., BROWN R. R., KAIHARA M., PRICE J. M. The excretion of N-methyl-2-pyridone-5-carboxamide by man following ingestion of several known or potential precursors. J Biol Chem. 1955 Nov;217(1):489–495. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES