Abstract
Two patients with atypical focal necrotising herpes simplex encephalitis are described. They presented with relatively mild clinical disease but despite treatment with acyclovir (10 mg/kg/day for three days in case 1 and 10 days in case 2) they developed dramatic, progressive changes (shown on brain CT) that mimicked space occupying lesions of the temporal lobes. Both patients therefore had a diagnostic and therapeutic temporal lesionectomy followed by further 10 day courses of acyclovir. They subsequently went on to make good clinical and neuropsychological recoveries.
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- Davis J. M., Davis K. R., Kleinman G. M., Kirchner H. S., Taveras J. M. Computed tomography of herpes simplex encephalitis, with clinicopathological correlation. Radiology. 1978 Nov;129(2):409–417. doi: 10.1148/129.2.409. [DOI] [PubMed] [Google Scholar]
- Enzmann D. R., Ranson B., Norman D., Talberth E. Computed tomography of herpes simplex encephalitis. Radiology. 1978 Nov;129(2):419–425. doi: 10.1148/129.2.419. [DOI] [PubMed] [Google Scholar]
- Kaufman D. M., Zimmerman R. D., Leeds N. E. Computed tomography in Herpes simplex encephalitis. Neurology. 1979 Oct;29(10):1392–1396. doi: 10.1212/wnl.29.10.1392. [DOI] [PubMed] [Google Scholar]
- Sköldenberg B., Forsgren M., Alestig K., Bergström T., Burman L., Dahlqvist E., Forkman A., Frydén A., Lövgren K., Norlin K. Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet. 1984 Sep 29;2(8405):707–711. doi: 10.1016/s0140-6736(84)92623-0. [DOI] [PubMed] [Google Scholar]
- VanLandingham K. E., Marsteller H. B., Ross G. W., Hayden F. G. Relapse of herpes simplex encephalitis after conventional acyclovir therapy. JAMA. 1988 Feb 19;259(7):1051–1053. [PubMed] [Google Scholar]
- Whitley R. J., Soong S. J., Linneman C., Jr, Liu C., Pazin G., Alford C. A. Herpes simplex encephalitis. Clinical Assessment. JAMA. 1982 Jan 15;247(3):317–320. [PubMed] [Google Scholar]