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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1994 Dec;57(12):1510–1517. doi: 10.1136/jnnp.57.12.1510

A neuropsychological instrument adding to the description of patients with suspected cortical dementia: the Milan overall dementia assessment.

M Brazzelli 1, E Capitani 1, S Della Sala 1, H Spinnler 1, M Zuffi 1
PMCID: PMC1073234  PMID: 7798982

Abstract

A new, short, neuropsychologically oriented test for dementia assessment--the Milan Overall Dementia Assessment (MODA)--is described. Age and education adjusted norms based on 217 healthy controls are given. A validation study on 312 outpatients suspected of dementia (121 with probable Alzheimer's disease) showed that the MODA differentiated patients with cognitive impairment from normal subjects more effectively than did the DSM III-R. The correlation between the MODA and the mini mental state examination was 0.63 in controls and 0.84 in patients with Alzheimer's dementia. The MODA test-retest reliability was 0.83. The test proved to be well suited to longitudinal studies.

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Selected References

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  1. Anthony J. C., LeResche L., Niaz U., von Korff M. R., Folstein M. F. Limits of the 'Mini-Mental State' as a screening test for dementia and delirium among hospital patients. Psychol Med. 1982 May;12(2):397–408. doi: 10.1017/s0033291700046730. [DOI] [PubMed] [Google Scholar]
  2. BENTON A. L., VANALLEN M. W., FOGEL M. L. TEMPORAL ORIENTATION IN CEREBRAL DISEASE. J Nerv Ment Dis. 1964 Aug;139:110–119. doi: 10.1097/00005053-196408000-00003. [DOI] [PubMed] [Google Scholar]
  3. Bleecker M. L., Bolla-Wilson K., Kawas C., Agnew J. Age-specific norms for the Mini-Mental State Exam. Neurology. 1988 Oct;38(10):1565–1568. doi: 10.1212/wnl.38.10.1565. [DOI] [PubMed] [Google Scholar]
  4. Chui H. C. Dementia. A review emphasizing clinicopathologic correlation and brain-behavior relationships. Arch Neurol. 1989 Jul;46(7):806–814. doi: 10.1001/archneur.1989.00520430102025. [DOI] [PubMed] [Google Scholar]
  5. DE RENZI E., VIGNOLO L. A. The token test: A sensitive test to detect receptive disturbances in aphasics. Brain. 1962 Dec;85:665–678. doi: 10.1093/brain/85.4.665. [DOI] [PubMed] [Google Scholar]
  6. Della Sala S., Laiacona M., Spinnler H., Ubezio C. A cancellation test: its reliability in assessing attentional deficits in Alzheimer's disease. Psychol Med. 1992 Nov;22(4):885–901. doi: 10.1017/s0033291700038460. [DOI] [PubMed] [Google Scholar]
  7. Della Sala S., Spinnler H. 'Indifférence amnésique' in a case of global amnesia following acute brain hypoxia. Eur Neurol. 1986;25(2):98–109. doi: 10.1159/000115994. [DOI] [PubMed] [Google Scholar]
  8. Faust D., Fogel B. S. The development and initial validation of a sensitive bedside cognitive screening test. J Nerv Ment Dis. 1989 Jan;177(1):25–31. doi: 10.1097/00005053-198901000-00004. [DOI] [PubMed] [Google Scholar]
  9. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  10. Friedland R. P. Epidemiology, education, and the ecology of Alzheimer's disease. Neurology. 1993 Feb;43(2):246–249. doi: 10.1212/wnl.43.2.246. [DOI] [PubMed] [Google Scholar]
  11. Galasko D., Klauber M. R., Hofstetter C. R., Salmon D. P., Lasker B., Thal L. J. The Mini-Mental State Examination in the early diagnosis of Alzheimer's disease. Arch Neurol. 1990 Jan;47(1):49–52. doi: 10.1001/archneur.1990.00530010061020. [DOI] [PubMed] [Google Scholar]
  12. Hill L. R., Klauber M. R., Salmon D. P., Yu E. S., Liu W. T., Zhang M., Katzman R. Functional status, education, and the diagnosis of dementia in the Shanghai survey. Neurology. 1993 Jan;43(1):138–145. doi: 10.1212/wnl.43.1_part_1.138. [DOI] [PubMed] [Google Scholar]
  13. Hughes C. P., Berg L., Danziger W. L., Coben L. A., Martin R. L. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982 Jun;140:566–572. doi: 10.1192/bjp.140.6.566. [DOI] [PubMed] [Google Scholar]
  14. Katzman R., Brown T., Thal L. J., Fuld P. A., Aronson M., Butters N., Klauber M. R., Wiederholt W., Pay M., Xiong R. B. Comparison of rate of annual change of mental status score in four independent studies of patients with Alzheimer's disease. Ann Neurol. 1988 Sep;24(3):384–389. doi: 10.1002/ana.410240306. [DOI] [PubMed] [Google Scholar]
  15. Katzman R. Education and the prevalence of dementia and Alzheimer's disease. Neurology. 1993 Jan;43(1):13–20. doi: 10.1212/wnl.43.1_part_1.13. [DOI] [PubMed] [Google Scholar]
  16. Kokmen E., Smith G. E., Petersen R. C., Tangalos E., Ivnik R. C. The short test of mental status. Correlations with standardized psychometric testing. Arch Neurol. 1991 Jul;48(7):725–728. doi: 10.1001/archneur.1991.00530190071018. [DOI] [PubMed] [Google Scholar]
  17. Lau C., Wands K., Merskey H., Boniferro M., Carriere L., Fox H., Hachinski V. C. Sensitivity and specificity of the extended scale for dementia. Arch Neurol. 1988 Aug;45(8):849–852. doi: 10.1001/archneur.1988.00520320035012. [DOI] [PubMed] [Google Scholar]
  18. Martin A., Brouwers P., Lalonde F., Cox C., Teleska P., Fedio P., Foster N. L., Chase T. N. Towards a behavioral typology of Alzheimer's patients. J Clin Exp Neuropsychol. 1986 Oct;8(5):594–610. doi: 10.1080/01688638608405178. [DOI] [PubMed] [Google Scholar]
  19. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  20. Nelson A., Fogel B. S., Faust D. Bedside cognitive screening instruments. A critical assessment. J Nerv Ment Dis. 1986 Feb;174(2):73–83. doi: 10.1097/00005053-198602000-00002. [DOI] [PubMed] [Google Scholar]
  21. Riege W. H., Metter E. J. Cognitive and brain imaging measures of Alzheimer's disease. Neurobiol Aging. 1988 Jan-Feb;9(1):69–86. doi: 10.1016/s0197-4580(88)80027-7. [DOI] [PubMed] [Google Scholar]
  22. Rosen W. G., Mohs R. C., Davis K. L. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984 Nov;141(11):1356–1364. doi: 10.1176/ajp.141.11.1356. [DOI] [PubMed] [Google Scholar]
  23. Roth M., Tym E., Mountjoy C. Q., Huppert F. A., Hendrie H., Verma S., Goddard R. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry. 1986 Dec;149:698–709. doi: 10.1192/bjp.149.6.698. [DOI] [PubMed] [Google Scholar]
  24. Salzman C., Kochansky G. E., Shader R. I. Rating scales for geriatric psychopharmacology--a review. Psychopharmacol Bull. 1972 Jul;8(3):3–50. [PubMed] [Google Scholar]
  25. Spinnler H., Della Sala S. The role of clinical neuropsychology in the neurological diagnosis of Alzheimer's disease. J Neurol. 1988 May;235(5):258–271. doi: 10.1007/BF00314172. [DOI] [PubMed] [Google Scholar]
  26. Welsh K. A., Butters N., Hughes J. P., Mohs R. C., Heyman A. Detection and staging of dementia in Alzheimer's disease. Use of the neuropsychological measures developed for the Consortium to Establish a Registry for Alzheimer's Disease. Arch Neurol. 1992 May;49(5):448–452. doi: 10.1001/archneur.1992.00530290030008. [DOI] [PubMed] [Google Scholar]
  27. Wilcock G. K., Hope R. A., Brooks D. N., Lantos P. L., Oppenheimer C., Reynolds G. P., Rossor M. N., Davies M. B. Recommended minimum data to be collected in research studies on Alzheimer's disease. The MRC (UK) Alzheimer's Disease Workshop Steering Committee. J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):693–700. doi: 10.1136/jnnp.52.6.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Zec R. F., Landreth E. S., Vicari S. K., Belman J., Feldman E., Andrise A., Robbs R., Becker R., Kumar V. Alzheimer Disease Assessment Scale: a subtest analysis. Alzheimer Dis Assoc Disord. 1992 Fall;6(3):164–181. doi: 10.1097/00002093-199206030-00004. [DOI] [PubMed] [Google Scholar]

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