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. 1978 Aug;41(8):746–753. doi: 10.1136/jnnp.41.8.746

Myasthenia gravis: further electrophysiological and ultrastructural analysis of transmission failure in the mouse passive transfer model.

K V Toyka, K L Birnberger, A P Anzil, C Schlegel, U Besinger, A Struppler
PMCID: PMC1083392  PMID: 210263

Abstract

Using the mouse passive transfer model the mean amplitude of miniature endplate potentials and endplate potentials of mice treated with myasthenic immunoglobulins was markedly decreased. Miniature endplate potential frequency and quantum content of endplate potentials were normal, arguing against a major presynaptic disarrangement. Under electron-microscopy no gross structural alterations of endplates were demonstrated. It is concluded that the mouse passive transfer model closely resembles human myasthenia gravis of recent onset.

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Selected References

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