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. 1971 Jun;34(3):253–259. doi: 10.1136/jnnp.34.3.253

Peripheral neuropathy after disulfiram administration

Christopher Gardner-Thorpe 1,2,1, Sidney Benjamin 1,2
PMCID: PMC1083460  PMID: 4328367

Abstract

Peripheral neuropathy and optic neuritis occurring in alcoholics are sometimes due to the toxic effects of disulfiram rather than to alcohol. Unless this is considered in the management of such patients it is likely that administration of the drug will be continued. In the past there have been reports of 16 cases of peripheral neuropathy and six cases of optic neuritis, possibly caused in this way; these reports are reviewed and a further six cases are described. The effects of disulfiram on the nervous system are briefly discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUNDIN T. ALKALOSIS DURING THE DISULFIRAM-ETHANOL REACTION IN UNANAESTHETIZED RABBITS. Acta Pharmacol Toxicol (Copenh) 1964;21:397–400. doi: 10.1111/j.1600-0773.1964.tb01804.x. [DOI] [PubMed] [Google Scholar]
  2. CHARATAN F. B. Peripheral neuritis following tetraethylthiuram disulphide treatment. Br Med J. 1953 Aug 15;2(4832):380–380. doi: 10.1136/bmj.2.4832.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHILD G. P., OSINSKI W., BENNETT R. E., DAVIDOFF E. Therapeutic results and clinical manifestations following the use of tetraethylthiuram disulfide (antabuse). Am J Psychiatry. 1951 Apr;107(10):774–780. doi: 10.1176/ajp.107.10.774. [DOI] [PubMed] [Google Scholar]
  4. Chaftez M. E. Drugs in the treatment of alcoholism. Med Clin North Am. 1967 Sep;51(5):1249–1259. [PubMed] [Google Scholar]
  5. FELDMAN D. J. Drug therapy of chronic alcoholism. Med Clin North Am. 1957 Mar;41(2):381–392. doi: 10.1016/s0025-7125(16)34444-3. [DOI] [PubMed] [Google Scholar]
  6. FENNELLY J., FRANK O., BAKER H., LEEVY C. M. PERIPHERAL NEUROPATHY OF THE ALCOHOLIC: I, AETIOLOGICAL ROLE OF ANEURIN AND OTHER B-COMPLEX VITAMINS. Br Med J. 1964 Nov 21;2(5420):1290–1292. doi: 10.1136/bmj.2.5420.1290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HAYMAN M., WILKINS P. A. Polyneuropathy as a complication of disulfiram therapy of alcoholism. Q J Stud Alcohol. 1956 Dec;17(4):601–607. [PubMed] [Google Scholar]
  8. HUMBLET M. Névrite rétrobulbaire chronique par antabuse. Bull Soc Belge Ophtalmol. 1953;104:297–301. [PubMed] [Google Scholar]
  9. Jacobsen E. Die Verwendung von Disulfiram (Antabus) Med Welt. 1967 Sep 23;38:2230–2234. [PubMed] [Google Scholar]
  10. MERLEVEDE E., CASIER H. [Content of carbon disulfide in the air expired by normal persons and by persons under the influence of ethyl alcohol during treatment by Antabuse (disulfiram) and sodium diethyldithiocarbamate]. Arch Int Pharmacodyn Ther. 1961 Jul 1;132:427–453. [PubMed] [Google Scholar]
  11. Mawdsley C., Mayer R. F. Nerve conduction in alcoholic polyneuropathy. Brain. 1965 Jun;88(2):335–356. doi: 10.1093/brain/88.2.335. [DOI] [PubMed] [Google Scholar]
  12. Morgan H. G. Acute neuropsychiatric complications of chronic alcoholism. Br J Psychiatry. 1968 Jan;114(506):85–92. doi: 10.1192/bjp.114.506.85. [DOI] [PubMed] [Google Scholar]
  14. Perdriel G., Chevaleraud J. A propos d'un nouveau cas de névrite optique due au disulfirame. Bull Soc Ophtalmol Fr. 1966 Feb;66(2):159–165. [PubMed] [Google Scholar]
  15. SCHEDIFKA R. DIE DISULFIRAMBEHANDLUNG DES ALKOHOLISMUS. Z Arztl Fortbild (Jena) 1964 Apr 15;58:424–435. [PubMed] [Google Scholar]

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