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. 1971 Jun;34(3):308–315. doi: 10.1136/jnnp.34.3.308

Spontaneous canine hydrocephalus: cerebrospinal fluid dynamics1

A Sahar 1,2,2, G M Hochwald 1,2,3, W J Kay 1,2,4, J Ransohoff 1,2
PMCID: PMC1083469  PMID: 5571319

Abstract

Cerebrospinal fluid dynamics were studied in 14 dogs with spontaneous hydrocephalus. In nine of the dogs aqueductal obstruction was observed and the remainder had a `communicating type' hydrocephalus. The major histological findings consisted of severe ependymal destruction, spongy changes in the periventricular white matter, increased density of capillaries in this area, and varying degrees of thickening, fibrosis, and fusion of the choroid villi. The formation and absorption of CSF were studied by perfusion of the cerebral ventricles. The rate of formation of CSF was found to decrease with perfusion pressure by Vf = 0·02595−0·00022 P ml./min (P = pressure in cm H2O). The absorption of spinal fluid was found to increase linearly with pressure by Va = 0·0165 + 0·00050 P. The various factors influencing the formation and absorption of the spinal fluid are discussed. The meaning and attainment of `arrest' of the hydrocephalic process in terms of the measured rates of CSF formation and absorption in these animals are considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS R. D., FISHER C. M., HAKIM S., OJEMANN R. G., SWEET W. H. SYMPTOMATIC OCCULT HYDROCEPHALUS WITH "NORMAL" CEREBROSPINAL-FLUID PRESSURE.A TREATABLE SYNDROME. N Engl J Med. 1965 Jul 15;273:117–126. doi: 10.1056/NEJM196507152730301. [DOI] [PubMed] [Google Scholar]
  2. BERING E. A., Jr, SATO O. HYDROCEPHALUS: CHANGES IN FORMATION AND ABSORPTION OF CEREBROSPINAL FLUID WITHIN THE CEREBRAL VENTRICLES. J Neurosurg. 1963 Dec;20:1050–1063. doi: 10.3171/jns.1963.20.12.1050. [DOI] [PubMed] [Google Scholar]
  3. DE S. N. A study of the changes in the brain in experimental internal hydrocephalus. J Pathol Bacteriol. 1950 Apr;62(2):197–208. doi: 10.1002/path.1700620207. [DOI] [PubMed] [Google Scholar]
  4. GREENFIELD J. C., Jr, TINDALL G. T. EFFECT OF ACUTE INCREASE IN INTRACRANIAL PRESSURE ON BLOOD FLOW IN THE INTERNAL CAROTID ARTERY OF MAN. J Clin Invest. 1965 Aug;44:1343–1351. doi: 10.1172/JCI105239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HEISEY S. R., HELD D., PAPPENHEIMER J. R. Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol. 1962 Nov;203:775–781. doi: 10.1152/ajplegacy.1962.203.5.775. [DOI] [PubMed] [Google Scholar]
  6. Hochwald G. M., Sahar A., Sadik A. R., Ransohoff J. Cerebrospinal fluid production and histological observations in animals with experimental obstructive hydrocephalus. Exp Neurol. 1969 Oct;25(2):190–199. doi: 10.1016/0014-4886(69)90043-0. [DOI] [PubMed] [Google Scholar]
  7. Hochwald G. M., Wallenstein M. Exchange of albumin between blood, cerebrospinal fluid, and brain in the cat. Am J Physiol. 1967 May;212(5):1199–1204. doi: 10.1152/ajplegacy.1967.212.5.1199. [DOI] [PubMed] [Google Scholar]
  8. Johnson R. T., Johnson K. P. Hydrocephalus following viral infection: the pathology of aqueductal stenosis developing after experimental mumps virus infection. J Neuropathol Exp Neurol. 1968 Oct;27(4):591–606. [PubMed] [Google Scholar]
  9. Norrell H., Wilson C., Howieson J., Megison L., Bertan V. Venous factors in infantile hydrocephalus. J Neurosurg. 1969 Nov;31(5):561–569. doi: 10.3171/jns.1969.31.5.0561. [DOI] [PubMed] [Google Scholar]
  10. SCHREINER G. E. Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med. 1950 May;74(1):117–120. doi: 10.3181/00379727-74-17827. [DOI] [PubMed] [Google Scholar]
  11. Sahar A., Hochwald G. M., Ransohoff J. Alternate pathway for cerebrospinal fluid absorption in animals with experimental obstructive hydrocephalus. Exp Neurol. 1969 Oct;25(2):200–206. doi: 10.1016/0014-4886(69)90044-2. [DOI] [PubMed] [Google Scholar]
  12. Sahar A., Hochwald G. M., Ransohoff J. Cerebrospinal fluid turnover in experimental hydrocephalic dogs. Neurology. 1971 Mar;21(3):218–224. doi: 10.1212/wnl.21.3.218. [DOI] [PubMed] [Google Scholar]
  13. Sahar A., Hochwald G. M., Ransohoff J. Experimental hydrocephalus: cerebrospinal fluid formation and ventricular size as a function of intraventricular pressure. J Neurol Sci. 1970 Jul;11(1):81–91. doi: 10.1016/0022-510x(70)90042-0. [DOI] [PubMed] [Google Scholar]
  14. Sahar A., Hochwald G. M., Sadik A. R., Ransohoff J. Cerebrospinal fluid absorption in animals with experimental obstructive hydrocephalus. Arch Neurol. 1969 Dec;21(6):638–644. doi: 10.1001/archneur.1969.00480180094009. [DOI] [PubMed] [Google Scholar]
  15. Weller R. O., Wiśniewski H. Histological and ultrastructural changes with experimental hydrocephalus in adult rabbits. Brain. 1969;92(4):819–828. doi: 10.1093/brain/92.4.819. [DOI] [PubMed] [Google Scholar]

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