Abstract
The metabolism of tryptophan by Taphrina deformans has been studied to confirm the reported ability of this organism to produce tryptamine. Such amine production was not observed, despite use of amine oxidase inhibitors at levels which should have resulted in the accumulation of tryptamine in the medium. It has been shown that the metabolites of tryptophan include indolepyruvic acid, indolelactic acid, tryptophol, and indoleacetic acid, and that the original report of tryptamine production must be reevaluated in light of the extraction procedures employed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HORITA A., MATSUMOTO C. The antagonism of hydrazine-type inhibitors of monoamine oxidase by sodium pyruvate. Life Sci. 1962 Oct;1:491–501. doi: 10.1016/0024-3205(62)90108-x. [DOI] [PubMed] [Google Scholar]
- KAPER J. M., VELDSTRA H. On the metabolism of tryptophan by Agrobacterium tumefaciens. Biochim Biophys Acta. 1958 Nov;30(2):401–420. doi: 10.1016/0006-3002(58)90065-9. [DOI] [PubMed] [Google Scholar]
- OBREITER J. B., STOWE B. B. CARBOXMETHYLCELLULOSE: A BINDER FOR THIN-LAYER CHROMATOGRAPHY OF LIPIDS AND INDOLES. J Chromatogr. 1964 Oct;16:226–228. doi: 10.1016/s0021-9673(01)82464-x. [DOI] [PubMed] [Google Scholar]
- WEISSBACH H., KING W., SJOERDSMA A., UDENFRIEND S. Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem. 1959 Jan;234(1):81–86. [PubMed] [Google Scholar]
- ZELLER E. A., SARKAR S. Amine oxidases. XIX. Inhibition of monoamine oxidase by phenylcyclopropylamines and iproniazid. J Biol Chem. 1962 Jul;237:2333–2336. [PubMed] [Google Scholar]