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editorial
. 1998 Feb 14;316(7131):563–564. doi: 10.1136/bmj.316.7131.563

Early identification of variant Creutzfeldt-Jakob disease

Some promising approaches but no clear answers yet

Maurizio Pocchiari 1
PMCID: PMC1112626  PMID: 9518890

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See pp 577, 593

References

  • 1.Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, et al. Transmissions to mice indicate that “new variant” CJD is caused by the BSE agent. Nature. 1997;389:498–501. doi: 10.1038/39057. [DOI] [PubMed] [Google Scholar]
  • 2.Hill AF, Desbruslais M, Joiner S, Sidle KC, Gowland I, Collinge J, et al. The same prion strain causes vCJD and BSE. Nature. 1997;389:448–450. doi: 10.1038/38925. [DOI] [PubMed] [Google Scholar]
  • 3.Hill AF, Zeidler M, Ironside J, Collinge J. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet. 1997;349:99–100. doi: 10.1016/S0140-6736(97)24002-X. [DOI] [PubMed] [Google Scholar]
  • 4.Kawashima I, Furukawa H, Doh-ura K, Iwaki T. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet. 1997;350:68–69. doi: 10.1016/S0140-6736(05)66274-5. [DOI] [PubMed] [Google Scholar]
  • 5.Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A, et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 1996;347:921–925. doi: 10.1016/s0140-6736(96)91412-9. [DOI] [PubMed] [Google Scholar]
  • 6.Zeidler M, Stewart GE, Barraclough CR, Bateman DE, Bates D, Burn DJ, et al. New variant Creutzfeldt-Jakob disease: neurological features and diagnostic tests. Lancet. 1991;350:903–907. doi: 10.1016/s0140-6736(97)07472-2. [DOI] [PubMed] [Google Scholar]
  • 7.Zeidler M, Johnstone EC, Bamber RW, Dickens CM, Fisher CJ, Francis AF, et al. New variant Creutzfeldt-Jakob disease: psychiatric features. Lancet. 1997;350:908–910. doi: 10.1016/s0140-6736(97)03148-6. [DOI] [PubMed] [Google Scholar]
  • 8.de Silva R, Patterson J, Hadley D, Russell A, Turner M, Zeidler M. HMPAO-SPECT in the identification of new variant Creutzfeldt-Jakob disease. BMJ. 1998;316:593–594. doi: 10.1136/bmj.316.7131.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Chazot G, Broussolle E, Lapras Cl, Blattler T, Aguzzi A, Kopp N. New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet. 1996;341:1181. doi: 10.1016/s0140-6736(96)90638-8. [DOI] [PubMed] [Google Scholar]
  • 10.Will RG, Zeidler M, Brown P, Harrington M, Lee KH. Kenney KL. Cerebrospinal-fluid test for new-variant Creutzfeldt-Jakob disease. Lancet. 1996;348:955. doi: 10.1016/s0140-6736(96)24040-1. [DOI] [PubMed] [Google Scholar]
  • 11.Pocchiari M. Prions and related neurological diseases. Mol Aspects Med. 1994;15:195–291. doi: 10.1016/0098-2997(94)90042-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Collinge J, Sidle KC, Meads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of “new variant.” Nature 1996;383:685-90. [DOI] [PubMed]
  • 13.Otto M, Wiltfang J, Schütz E, Zerr I, Otto A, Pfahlberg A, et al. Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. BMJ. 1998;316:577–582. doi: 10.1136/bmj.316.7131.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Korth C, Stierli B, Streit P, Moser M, Schaller O, Fischer R, et al. Prion (PrPSc) specific epitope defined by a monoclonal antibody. Nature. 1997;390:74–77. doi: 10.1038/36337. [DOI] [PubMed] [Google Scholar]
  • 15.Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, Bluethmann H, et al. A crucial role for B cells in neuroinvasive scrapie. Nature. 1997;390:687–690. doi: 10.1038/37789. [DOI] [PubMed] [Google Scholar]

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