Abstract
OBJECTIVE--A retrospective cohort study of 640 male polypropylene production workers in Germany was performed to evaluate the reported association between colorectal cancer and polypropylene. METHOD--The follow up period was 1956 to 1990. Expected numbers of cancers were derived from incidence rates adjusted for age and calendar year from the Saarland cancer registry. RESULTS--Three colorectal cancers were identified compared with 4.0 expected (standardised incidence ration (SIR) = 0.75, 95% confidence interval (95% CI): 0.15-2.19). For total cancers there were 27 cases in the cohort compared with 35.4 expected (SIR = 0.76, 95% CI: 0.50-1.11). DISCUSSION--These results do not support earlier reports of a link between polypropylene production and colorectal cancer, but are consistent with a number of recent investigations of polypropylene production workers that have reported no association with risk of colorectal cancer. Due to the small size of this and other similar studies, however, a small to moderate increase in risk cannot be ruled out.
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Selected References
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- Acquavella J. F., Douglass T. S., Phillips S. C. Evaluation of excess colorectal cancer incidence among workers involved in the manufacture of polypropylene. J Occup Med. 1988 May;30(5):438–442. doi: 10.1097/00043764-198805000-00012. [DOI] [PubMed] [Google Scholar]
- Acquavella J. F., Owen C. V. Assessment of colorectal cancer incidence among polypropylene pilot plant employees. J Occup Med. 1990 Feb;32(2):127–130. [PubMed] [Google Scholar]
- Bouskill J. Absence of risk of colorectal cancer among workers at a UK polypropylene production plant. Occup Environ Med. 1994 Nov;51(11):786–786. doi: 10.1136/oem.51.11.786. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Christie D., Robinson K., Gordon I., Bisby J. A prospective study in the Australian petroleum industry. II. Incidence of cancer. Br J Ind Med. 1991 Aug;48(8):511–514. doi: 10.1136/oem.48.8.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldberg M. S., Thériault G. Retrospective cohort study of workers of a synthetic textiles plant in Quebec: II. Colorectal cancer mortality and incidence. Am J Ind Med. 1994 Jun;25(6):909–922. doi: 10.1002/ajim.4700250613. [DOI] [PubMed] [Google Scholar]
- Lewis R. J., Schnatter A. R., Lerman S. E. Colorectal cancer incidence among polypropylene manufacturing workers. An update. J Occup Med. 1994 Jun;36(6):652–659. [PubMed] [Google Scholar]
- Vobecky J., Devroede G., Caro J. Risk of large-bowel cancer in synthetic fiber manufacture. Cancer. 1984 Dec 1;54(11):2537–2542. doi: 10.1002/1097-0142(19841201)54:11<2537::aid-cncr2820541138>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]