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. 1997 Jul;54(7):477–482. doi: 10.1136/oem.54.7.477

Laryngeal and hypopharyngeal cancer and occupation: results of a case control-study.

P Goldberg 1, A Leclerc 1, D Luce 1, J F Morcet 1, J Brugère 1
PMCID: PMC1128816  PMID: 9282123

Abstract

OBJECTIVES: To ascertain whether certain occupations are associated with laryngeal or hypopharyngeal cancer. METHODS: A hospital based case-control study was carried out in 15 hospitals in France. It included 528 male cases diagnosed between January 1989 and April 1991, and 305 male controls with various other types of cancer. Interviews were carried out to obtain lifetime job histories and information on potential confounders. Logistic regression was used to compute the odds ratios (OR) for each of about 80 occupations and industries. RESULTS: There was an excess risk of laryngeal and hypopharyngeal cancer among service workers (OR 2.2, 95% confidence interval (95% CI) 1.3 to 3.9), agricultural and animal husbandry workers (OR 1.6, 95% CI 0.9 to 2.8), miners and quarrymen (OR 2.0, 95% CI 0.9 to 4.3), plumbers and pipe fitters (OR 2.6, 95% CI 0.8 to 8.1), glass formers and potters (OR 4.3, 95% CI 1.0 to 18) transport equipment operators (OR 1.5, 95% CI 1.0 to 2.5), and unskilled workers (OR 1.7, 95% CI 1.0 to 2.9). Analysis by industrial branch showed an excess risk for coal mining (OR 2.1, 95% CI 1.1 to 4.1), manufacture of metal products (OR 1.9, 95% CI 1.0 to 3.3), and administration and sanitary services (OR 1.7, 95% CI 1.1 to 2.5). CONCLUSION: These results suggest that occupational exposure might have a role in generating laryngeal and hypopharyngeal cancer, and indicate the need for further evaluation of these findings, an for the identification of the carcinogens which might account for the excess risks found for certain occupations.

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Selected References

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  1. Ahrens W., Jöckel K. H., Patzak W., Elsner G. Alcohol, smoking, and occupational factors in cancer of the larynx: a case-control study. Am J Ind Med. 1991;20(4):477–493. doi: 10.1002/ajim.4700200404. [DOI] [PubMed] [Google Scholar]
  2. Burch J. D., Howe G. R., Miller A. B., Semenciw R. Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: a case-control study. J Natl Cancer Inst. 1981 Dec;67(6):1219–1224. [PubMed] [Google Scholar]
  3. Eisen E. A., Tolbert P. E., Hallock M. F., Monson R. R., Smith T. J., Woskie S. R. Mortality studies of machining fluid exposure in the automobile industry. III: A case-control study of larynx cancer. Am J Ind Med. 1994 Aug;26(2):185–202. doi: 10.1002/ajim.4700260205. [DOI] [PubMed] [Google Scholar]
  4. Eisen E. A., Tolbert P. E., Monson R. R., Smith T. J. Mortality studies of machining fluid exposure in the automobile industry I: A standardized mortality ratio analysis. Am J Ind Med. 1992;22(6):809–824. doi: 10.1002/ajim.4700220604. [DOI] [PubMed] [Google Scholar]
  5. Guenel P., Engholm G., Lynge E. Laryngeal cancer in Denmark: a nationwide longitudinal study based on register linkage data. Br J Ind Med. 1990 Jul;47(7):473–479. doi: 10.1136/oem.47.7.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Guénel P., Chastang J. F., Luce D., Leclerc A., Brugère J. A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer. J Epidemiol Community Health. 1988 Dec;42(4):350–354. doi: 10.1136/jech.42.4.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haguenoer J. M., Cordier S., Morel C., Lefebvre J. L., Hemon D. Occupational risk factors for upper respiratory tract and upper digestive tract cancers. Br J Ind Med. 1990 Jun;47(6):380–383. doi: 10.1136/oem.47.6.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Huebner W. W., Schoenberg J. B., Kelsey J. L., Wilcox H. B., McLaughlin J. K., Greenberg R. S., Preston-Martin S., Austin D. F., Stemhagen A., Blot W. J. Oral and pharyngeal cancer and occupation: a case-control study. Epidemiology. 1992 Jul;3(4):300–309. doi: 10.1097/00001648-199207000-00005. [DOI] [PubMed] [Google Scholar]
  9. Luce D., Leclerc A., Morcet J. F., Casal-Lareo A., Gérin M., Brugère J., Haguenoer J. M., Goldberg M. Occupational risk factors for sinonasal cancer: a case-control study in France. Am J Ind Med. 1992;21(2):163–175. doi: 10.1002/ajim.4700210206. [DOI] [PubMed] [Google Scholar]
  10. Maier H., Fischer G., Sennewald E., Heller W. D. Berufliche Risikofaktoren für Rachenkrebs. Ergebnisse der Heidelberger Rachenkrebsstudie. HNO. 1994 Sep;42(9):530–540. [PubMed] [Google Scholar]
  11. Maier H., Gewelke U., Dietz A., Thamm H., Heller W. D., Weidauer H. Kehlkopfkarzinom und Berufstätigkeit--Ergebnisse der Heidelberger Kehlkopfkrebsstudie. HNO. 1992 Feb;40(2):44–51. [PubMed] [Google Scholar]
  12. Muscat J. E., Wynder E. L. Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. Cancer. 1992 May 1;69(9):2244–2251. doi: 10.1002/1097-0142(19920501)69:9<2244::aid-cncr2820690906>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  13. Piolatto G., Negri E., La Vecchia C., Pira E., Decarli A., Peto J. An update of cancer mortality among chrysotile asbestos miners in Balangero, northern Italy. Br J Ind Med. 1990 Dec;47(12):810–814. doi: 10.1136/oem.47.12.810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Savitz D. A., Olshan A. F. Multiple comparisons and related issues in the interpretation of epidemiologic data. Am J Epidemiol. 1995 Nov 1;142(9):904–908. doi: 10.1093/oxfordjournals.aje.a117737. [DOI] [PubMed] [Google Scholar]
  15. Smith A. H., Handley M. A., Wood R. Epidemiological evidence indicates asbestos causes laryngeal cancer. J Occup Med. 1990 Jun;32(6):499–507. doi: 10.1097/00043764-199006000-00005. [DOI] [PubMed] [Google Scholar]
  16. Soskolne C. L., Jhangri G. S., Siemiatycki J., Lakhani R., Dewar R., Burch J. D., Howe G. R., Miller A. B. Occupational exposure to sulfuric acid in southern Ontario, Canada, in association with laryngeal cancer. Scand J Work Environ Health. 1992 Aug;18(4):225–232. doi: 10.5271/sjweh.1585. [DOI] [PubMed] [Google Scholar]
  17. Tuyns A. J., Estève J., Raymond L., Berrino F., Benhamou E., Blanchet F., Boffetta P., Crosignani P., del Moral A., Lehmann W. Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer. 1988 Apr 15;41(4):483–491. doi: 10.1002/ijc.2910410403. [DOI] [PubMed] [Google Scholar]
  18. Wortley P., Vaughan T. L., Davis S., Morgan M. S., Thomas D. B. A case-control study of occupational risk factors for laryngeal cancer. Br J Ind Med. 1992 Dec;49(12):837–844. doi: 10.1136/oem.49.12.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Zagraniski R. T., Kelsey J. L., Walter S. D. Occupational risk factors for laryngeal carcinoma: Connecticut, 1975-1980. Am J Epidemiol. 1986 Jul;124(1):67–76. doi: 10.1093/oxfordjournals.aje.a114371. [DOI] [PubMed] [Google Scholar]
  20. Zheng W., Blot W. J., Shu X. O., Gao Y. T., Ji B. T., Ziegler R. G., Fraumeni J. F., Jr Diet and other risk factors for laryngeal cancer in Shanghai, China. Am J Epidemiol. 1992 Jul 15;136(2):178–191. doi: 10.1093/oxfordjournals.aje.a116484. [DOI] [PubMed] [Google Scholar]

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