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. 1974 Aug;121(2):106–111.

The Use of Propoxyphene Napsylate in the Treatment of Heroin and Methadone Addiction

Daryl S Inaba 1,2, George R Gay 1,2, Craig A Whitehead 1,2, John A Newmeyer 1,2, Dan Bergin 1,2
PMCID: PMC1129514  PMID: 4847425

Abstract

The use of methadone in the treatment of heroin addiction continues to be controversial. Propoxyphene napsylate (Darvon N®) is a possible alternative and a pilot study was conducted to test its acceptability, safety and clinical efficacy in treating long term, “multi-relapse” heroin addicts.

Findings indicate that propoxyphene napsylate suppresses many of the symptoms associated with opioid withdrawal phenomena. It should be viewed as a very promising therapeutic tool to be used in conjunction with psychological counseling and socio-vocational rehabilitation in detoxification and maintenance therapy for heroin or methadone addiction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronow R., Paul S. D., Woolley P. V. Childhood poisoning. An unfortunate consequence of methadone availability. JAMA. 1972 Jan 17;219(3):321–324. doi: 10.1001/jama.219.3.321. [DOI] [PubMed] [Google Scholar]
  2. Bogartz L. J., Miller W. C. Pulmonary edema associated with propoxyphene intoxication. JAMA. 1971 Jan 11;215(2):259–262. [PubMed] [Google Scholar]
  3. Chambers C. D., Moffett A. D. Five patterns of darvon abuse. Int J Addict. 1971 Mar;6(1):173–189. doi: 10.3109/10826087109062262. [DOI] [PubMed] [Google Scholar]
  4. DOLE V. P., NYSWANDER M. A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE. JAMA. 1965 Aug 23;193:646–650. doi: 10.1001/jama.1965.03090080008002. [DOI] [PubMed] [Google Scholar]
  5. Dole V. P., Nyswander M. E., Kreek M. J. Narcotic blockade. Arch Intern Med. 1966 Oct;118(4):304–309. [PubMed] [Google Scholar]
  6. Dole V. P., Nyswander M. E., Warner A. Successful treatment of 750 criminal addicts. JAMA. 1968 Dec 16;206(12):2708–2711. [PubMed] [Google Scholar]
  7. Dole V. P., Robinson J. W., Orraca J., Towns E., Searcy P., Caine E. Methadone treatment of randomly selected criminal addicts. N Engl J Med. 1969 Jun 19;280(25):1372–1375. doi: 10.1056/NEJM196906192802502. [DOI] [PubMed] [Google Scholar]
  8. Emmerson J. L., Gibson W. R., Harris P. N., Todd G. C., Pierce E. C., Anderson R. C. Short-term toxicity of propoxyphene salts in rats and dogs. Toxicol Appl Pharmacol. 1971 Jul;19(3):452–470. doi: 10.1016/0041-008x(71)90004-4. [DOI] [PubMed] [Google Scholar]
  9. Emmerson J. L., Owen N. V., Koenig G. R., Markham J. K., Anderson R. C. Reproduction and teratology studies on propoxyphene napsylate. Toxicol Appl Pharmacol. 1971 Jul;19(3):471–479. doi: 10.1016/0041-008x(71)90005-6. [DOI] [PubMed] [Google Scholar]
  10. Fier M. Addiction to a massive dosage of Darvon: a case report. J Med Soc N J. 1973 May;70(5):393–395. [PubMed] [Google Scholar]
  11. Gary N. E., Maher J. F., DeMyttenaere M. H., Liggero S. H., Scott K. G., Matusiak W., Schreiner G. E. Acute propoxyphene hydrochloride intoxication. Arch Intern Med. 1968 May;121(5):453–457. [PubMed] [Google Scholar]
  12. Gay G. R., Matzger A. D., Bathurst W., Smith D. E. Short-term heroin detoxification on an outpatient basis. Int J Addict. 1971 Jun;6(2):241–264. doi: 10.3109/10826087109057784. [DOI] [PubMed] [Google Scholar]
  13. Gruber C. M., Jr, Stephens V. C., Terrill P. M. Propoxyphene napsylate: chemistry and experimental design. Toxicol Appl Pharmacol. 1971 Jul;19(3):423–426. doi: 10.1016/0041-008x(71)90001-9. [DOI] [PubMed] [Google Scholar]
  14. Hunt V. Treatment of dextropropoxyphene poisoning. Br Med J. 1973 Mar 3;1(5852):554–554. doi: 10.1136/bmj.1.5852.554-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kersh E. S. Treatment of propoxyphene overdosage with naloxone. Chest. 1973 Jan;63(1):112–114. doi: 10.1378/chest.63.1.112. [DOI] [PubMed] [Google Scholar]
  16. Kiplinger G. F., Gruber C. M., Jr, Pierce E. C. A comparative study of the effects of chronic administration of propoxyphene salts to normal volunteers. Toxicol Appl Pharmacol. 1971 Jul;19(3):528–536. doi: 10.1016/0041-008x(71)90012-3. [DOI] [PubMed] [Google Scholar]
  17. Mattson R. H., Weisman G. K., Levy L. L. Dependence and central nervous system toxicity associated with the use of propoxyphene hydrochloride. Trans Am Neurol Assoc. 1969;94:299–301. [PubMed] [Google Scholar]
  18. McMahon R. E., Ridolfo A. S., Culp H. W., Wolen R. L., Marshall F. J. The fate of radiocarbon-labeled propoxyphene in rat, dog, and human. Toxicol Appl Pharmacol. 1971 Jul;19(3):427–444. doi: 10.1016/0041-008x(71)90002-0. [DOI] [PubMed] [Google Scholar]
  19. Owen N. L. Abuse of propoxyphene. JAMA. 1971 Jun 21;216(12):2016–2016. doi: 10.1001/jama.1971.03180380070025. [DOI] [PubMed] [Google Scholar]
  20. Salguero C. H., Villarreal J. E., Hug C. C., Jr, Domino E. F. Propoxyphene dependence. JAMA. 1969 Oct 6;210(1):135–136. [PubMed] [Google Scholar]
  21. Sturner W. Q., Garriott J. C. Deaths involving propoxyphene. A study of 41 cases over a two-year period. JAMA. 1973 Mar 5;223(10):1125–1130. doi: 10.1001/jama.223.10.1125. [DOI] [PubMed] [Google Scholar]
  22. Tennant F. S., Jr Complications of propoxyphene abuse. Arch Intern Med. 1973 Aug;132(2):191–194. [PubMed] [Google Scholar]
  23. Wolfe R. C., Reidenberg M., Vispo R. H. Propoxyphene (Darvon) addiction and withdrawal syndrome. Ann Intern Med. 1969 Apr;70(4):773–776. doi: 10.7326/0003-4819-70-4-773. [DOI] [PubMed] [Google Scholar]
  24. Young D. J. Propoxyphene suicides. Report of nine cases. Arch Intern Med. 1972 Jan;129(1):62–66. doi: 10.1001/archinte.129.1.62. [DOI] [PubMed] [Google Scholar]

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