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. 1991 Nov 15;280(Pt 1):51–55. doi: 10.1042/bj2800051

Comparison of the domain-level organization of starch hydrolases and related enzymes.

H M Jespersen 1, E A MacGregor 1, M R Sierks 1, B Svensson 1
PMCID: PMC1130598  PMID: 1741756

Abstract

Structure-prediction and hydrophobic-cluster analysis of several starch hydrolases and related enzymes indicated the organization of eleven domain types. Most enzymes possess a catalytic (beta/alpha)8-barrel and a smaller C-terminal domain as seen in crystal structures of alpha-amylase and cyclodextrin glucanotransferase. Some also have a starch-granule-binding domain. Enzymes breaking or forming endo-alpha-1,6 linkages contain domains N-terminal to the (beta/alpha)8-barrel.

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Selected References

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