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. 1992 Apr 15;283(Pt 2):403–408. doi: 10.1042/bj2830403

Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells.

D J Grainger 1, T R Hesketh 1, P L Weissberg 1, J C Metcalfe 1
PMCID: PMC1131048  PMID: 1575685

Abstract

Hexamethylenebisacetamide (HMBA) selectively and reversibly inhibited proliferation of human and rat vascular smooth-muscle cells (VSMCs) compared with endothelial cells, fibroblasts or lymphocytes. Half-maximal inhibition of VSMC proliferation occurred at 2-5 mM-HMBA, and at 30- greater than 50 mM for other cell types. HMBA also prevented de-differentiation, defined by the loss of smooth-muscle-specific myosin heavy chain, of primary rat VSMCs and caused partial re-differentiation of subcultured cells. Other inhibitors of ADP-ribosyltransferase were also selective inhibitors of VSMC proliferation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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