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. 1990 Sep 15;270(3):803–807. doi: 10.1042/bj2700803

Contribution of glycerol and alanine to basal hepatic glucose production in the genetically obese (fa/fa) rat.

J Terrettaz 1, B Jeanrenaud 1
PMCID: PMC1131804  PMID: 2241912

Abstract

Increased hepatic glucose production has been reported to occur in the insulin-resistant genetically obese fa/fa rats. The possible existence of an increased basal gluconeogenesis in obese rats was investigated, upon comparing the metabolic fate of glycerol and alanine in liver of fed anaesthetized lean and genetically obese (fa/fa) rats. Glycerol turnover rate in obese animals was 3 times that of the lean. This increase in glycerol turnover rate was associated with an increase in blood glycerol levels in obese animals. The contribution of glycerol to glucose production was significantly increased in obese animals. In contrast, the contribution of alanine to the hepatic glucose production was similar to lean and obese animals. A higher incorporation of glucose, glycerol and alanine into hepatic lipids was observed in obese animals than in controls. It is concluded that in fed genetically obese (fa/fa) rats the high blood glycerol concentrations is a major driving force for the increased basal hepatic conversion of this substrate into glucose.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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