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. 1993 Jan 1;289(Pt 1):65–69. doi: 10.1042/bj2890065

Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2).

Y A DeClerck 1, T D Yean 1, Y Lee 1, J M Tomich 1, K E Langley 1
PMCID: PMC1132131  PMID: 8424773

Abstract

Analysis of the functional domain of tissue inhibitor of metallo-proteinases-2 (TIMP-2) was performed using limited proteolytic degradation with trypsin. This treatment generated a 13.5 kDa fragment which was purified and shown to consist of an uncleaved N-terminal region extending from residue 1 to residue 132. The fragment retains the ability to inhibit activated interstitial collagenase and to block the autocatalytic activation of procollagenase.

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Selected References

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