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. 1995 Nov 15;312(Pt 1):315–318. doi: 10.1042/bj3120315

Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals.

S Fujiwara 1, T Noguchi 1
PMCID: PMC1136261  PMID: 7492331

Abstract

It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.

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Selected References

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