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. 1994 Feb 1;297(Pt 3):463–466. doi: 10.1042/bj2970463

The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity.

J F Haeuw 1, T Grard 1, C Alonso 1, G Strecker 1, J C Michalski 1
PMCID: PMC1137856  PMID: 8110182

Abstract

The substrate specificity of the core-specific rat liver lysosomal alpha(1-6)-mannosidase was investigated using mannosylated oligosaccharides and glycoasparagines. Hydrolysis of Man(alpha 1-6) linkage hydrolysis was demonstrated to follow the action of endoglycosidases, namely aspartyl-N-acetyl-beta-D-glucosaminidase and endo-N-acetyl-beta-D-glucosaminidase. The results are discussed with respect to the nature of the carbohydrate materials stored in the tissues and excreted in the urine from patients suffering from aspartylglucosaminuria and fucosidosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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