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. 1989 May 1;259(3):905–907. doi: 10.1042/bj2590905

Inhibition of aspartic proteinases by alpha 2-macroglobulin.

D J Thomas 1, A D Richards 1, J Kay 1
PMCID: PMC1138603  PMID: 2471514

Abstract

The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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