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. 1987 Dec;40(12):1456–1462. doi: 10.1136/jcp.40.12.1456

Study of childhood renal tumours using a monoclonal antibody to Tamm-Horsfall protein.

S Kumar 1, H B Marsden 1, B Jasani 1, P Kumar 1
PMCID: PMC1141283  PMID: 3429675

Abstract

A monoclonal antibody to Tamm-Horsfall glycoprotein was used for the immuno-localization of Tamm-Horsfall protein in formalin fixed, paraffin embedded tissue sections of childhood renal tumours, normal children's kidneys, and human fetal kidneys. The procedure was a dinitrophenyl hapten sandwich staining method. The antibody, diluted 1/100,000, gave a very strong and specific staining of the loop of Henle and distal tubules of normal and fetal kidneys. No staining was seen in Wilms' tumour, mesoblastic nephroma, and bone metastasizing renal tumour of childhood. In contrast, two of seven renal carcinomas and three of four rhabdoid renal tumours were positive for Tamm-Horsfall protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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