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. 1988 Mar;41(3):280–283. doi: 10.1136/jcp.41.3.280

Malignant progression of laryngeal papilloma associated with human papilloma virus type 6 (HPV-6) DNA.

A P Zarod 1, J D Rutherford 1, G Corbitt 1
PMCID: PMC1141424  PMID: 2834418

Abstract

A case of laryngeal squamous papilloma in the early stages of development showed histological features suggestive of virus infection. Five years later positive evidence of HPV-6 infection was obtained at a time when the lesion had developed into a squamous cell carcinoma. It is concluded that this case represents a complete example of the virus to papilloma to carcinoma sequence, and as far as is known, is the first reported case of its kind in the larynx.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brichácek B., Hirsch I., Síbl O., Vilikusová E., Vonka V. Association of some supraglottic laryngeal carcinomas with EB virus. Int J Cancer. 1983 Aug 15;32(2):193–197. doi: 10.1002/ijc.2910320209. [DOI] [PubMed] [Google Scholar]
  2. Capper J. W., Bailey C. M., Michaels L. Squamous papillomas of the larynx in adults. A review of 63 cases. Clin Otolaryngol Allied Sci. 1983 Apr;8(2):109–119. doi: 10.1111/j.1365-2273.1983.tb01414.x. [DOI] [PubMed] [Google Scholar]
  3. Cook T. A., Brunschwig J. P., Butel J. S., Cohn A. M., Goepfert H., Rawls W. E. Laryngeal papilloma: etiologic and therapeutic considerations. Ann Otol Rhinol Laryngol. 1973 Sep-Oct;82(5):649–655. doi: 10.1177/000348947308200507. [DOI] [PubMed] [Google Scholar]
  4. Crum C. P., Ikenberg H., Richart R. M., Gissman L. Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med. 1984 Apr 5;310(14):880–883. doi: 10.1056/NEJM198404053101403. [DOI] [PubMed] [Google Scholar]
  5. Dürst M., Gissmann L., Ikenberg H., zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3812–3815. doi: 10.1073/pnas.80.12.3812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gisser S. D. Papovavirus and squamous cell carcinoma. Hum Pathol. 1981 Feb;12(2):190–193. doi: 10.1016/s0046-8177(81)80108-6. [DOI] [PubMed] [Google Scholar]
  7. Gissmann L., Wolnik L., Ikenberg H., Koldovsky U., Schnürch H. G., zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci U S A. 1983 Jan;80(2):560–563. doi: 10.1073/pnas.80.2.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Green M., Brackmann K. H., Sanders P. R., Loewenstein P. M., Freel J. H., Eisinger M., Switlyk S. A. Isolation of a human papillomavirus from a patient with epidermodysplasia verruciformis: presence of related viral DNA genomes in human urogenital tumors. Proc Natl Acad Sci U S A. 1982 Jul;79(14):4437–4441. doi: 10.1073/pnas.79.14.4437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grussendorf E. I., Gahlen W. Metaplasia of a verruca vulgaris into spinocellular carcinoma. Dermatologica. 1975;150(5):295–299. doi: 10.1159/000251446. [DOI] [PubMed] [Google Scholar]
  10. Lack E. E., Jenson A. B., Smith H. G., Healy G. B., Pass F., Vawter G. F. Immunoperoxidase localization of human papillomavirus in laryngeal papillomas. Intervirology. 1980;14(3-4):148–154. doi: 10.1159/000149176. [DOI] [PubMed] [Google Scholar]
  11. Lancaster W. D., Olson C. Animal papillomaviruses. Microbiol Rev. 1982 Jun;46(2):191–207. doi: 10.1128/mr.46.2.191-207.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MAJOROS M., DEVINE K. D., PARKHILL E. M. MALIGNANT TRANSFORMATION OF BENIGN LARYNGEAL PAPILLOMAS IN CHILDREN AFTER RADIATION THERAPY. Surg Clin North Am. 1963 Aug;43:1049–1061. doi: 10.1016/s0039-6109(16)37041-4. [DOI] [PubMed] [Google Scholar]
  13. Mounts P., Kashima H. Association of human papillomavirus subtype and clinical course in respiratory papillomatosis. Laryngoscope. 1984 Jan;94(1):28–33. doi: 10.1002/lary.5540940106. [DOI] [PubMed] [Google Scholar]
  14. Mounts P., Shah K. V., Kashima H. Viral etiology of juvenile- and adult-onset squamous papilloma of the larynx. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5425–5429. doi: 10.1073/pnas.79.17.5425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Orth G., Jablonska S., Jarzabek-Chorzelska M., Obalek S., Rzesa G., Favre M., Croissant O. Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis. Cancer Res. 1979 Mar;39(3):1074–1082. [PubMed] [Google Scholar]
  16. SVOBODA D. J., KIRCHNER F. R., PROUD G. O. ELECTRON MICROSCOPIC STUDY OF HUMAN LARYNGEAL PAPILLOMATOSIS. Cancer Res. 1963 Aug;23:1084–1089. [PubMed] [Google Scholar]
  17. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  18. Stevens J. G., Wettstein F. O. Multiple copies of Shope virus DNA are present in cells of benign and malignant non-virus-producing neoplasms. J Virol. 1979 Jun;30(3):891–898. doi: 10.1128/jvi.30.3.891-898.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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